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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 150 (1991), S. 357-361 
    ISSN: 1432-1076
    Keywords: Ventilation ; High frequency oscillation ; Neonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Combined high frequency oscillation (HFO) with conventional ventilation was used on a group of 12 ventilator dependent neonates in order to investigate the frequency response of the respiratory system to HFO. Pressure oscillations were measured at the airway opening with a transducer and volume oscillations at the chest wall using a calibrated respiratory jacket. Pressure oscillations increased with increasing frequency but the oscillating volumes showed a variable pattern with maximum oscillating volumes of up to 4 ml/kg. Three babies showed no change in volume between 2–25 Hz, 3 babies showed increasing volumes up to 25 Hz and the remainder showed a maximum volume (or resonant frequency) at 15–20 Hz. Oscillating volumes were higher when the conventional ventilator was in the expiratory phase. The differences in frequency response were unrelated to severity of lung disease, birth weight, age at testing, or size of the endotracheal (ET) tube. Local factors in the ET tube and large airways may account for some of the observed differences.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 846-850 
    ISSN: 1432-1076
    Keywords: High frequency oscillation ; Dynamic lung inflation ; Positive end-expiratory pressure ; Neonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of high frequency oscillation (HFO) on dynamic lung inflation were examined in 22 neonates ventilated for respiratory disease. HFO was combined with conventional ventilation and a series of frequencies from 2–25 Hz was tested. Dynamic lung inflation was measured using a jacket plethysmograph which was converted to a measure of alveolar pressure using the complicance of the respiratory system obtained during conventional ventilation. The results showed an increase in dynamic lung inflation with frequency such that volume increased by 0.4 ml for each increase of 10 Hz. Alveolar pressure increased by 1.2 cm H2O for each increase of 10 Hz. Dynamic lung inflation also increased with increased volumes of oscillation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 154 (1995), S. 320-325 
    ISSN: 1432-1076
    Keywords: Key words Children ; Cough ; Asthma ; Night
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between night cough and other indices of asthma severity was studied in 21 children with clinically stable asthma and persistent night cough. Overnight cough was quantified and related to symptom scores, oxygen saturation (SaO2) during sleep, evening and morning peak flow recordings and daytime tests of lung function. In the index group the median number of coughing episodes was 23 (range 1–158). Only 4 children had counts of 〈10 overnight, similar to the comparison group of 12 children all of whom had counts of 〈10. There was a trend towards the association of overnight cough with reduced evening peak flow (r = –0.407, P = 0.07) and reduced SaO2 (r = –0.36, P = 0.10). Abnormalities in daytime tests of lung function were observed in 13 children. There was no relationship between night cough and daytime indices of lung function abnormality although children with more severe daytime abnormalities also had significant night cough. Conversely, five children with chronic night cough had normal daytime function. Conclusion Night-time cough in children with asthma is not simply a reflection of daytime lung function status, whereas, overnight SaO2 correlates well. Other factors need to be explored to explain the variability of night-time cough in these children.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 154 (1995), S. 320-325 
    ISSN: 1432-1076
    Keywords: Children ; Cough ; Asthma ; Night
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between night cough and other indices of asthma severity was studied in 21 children with clinically stable asthma and persistent night cough. Overnight cough was quantified and related to symptom scores, oxygen saturation (SaO2) during sleep, evening and morning peak flow recordings and daytime tests of lung function. In the index group the median number of coughing episodes was 23 (range 1–158). Only 4 children had counts of 〈10 overnight, similar to the comparison group of 12 children all of whom had counts of 〈10. There was a trend towards the association of overnight cough with reduced evening peak flow (r=−0.407,P=0.07) and reduced SaO2 (r=−0.36,P=0.10). Abnormalities in daytime tests of lung function were observed in 13 children. There was no relationship between night cough and daytime indices of lung function abnormality although children with more severe daytime abnormalities also had significant night cough. Conversely, five children with chronic night cough had normal daytime function. Conclusion Night-time cough in children with asthma is not simply a reflection of daytime lung function status, whereas, overnight SaO2 correlates well. Other factors need to be explored to explain the variability of night-time cough in these children.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 458-460 
    ISSN: 1432-1076
    Keywords: Neonate ; Lung function ; Amniocentesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lung function tests were carried out on 39 healthy full term babies born after pregnancies subjected to mid-trimester amniocentesis. The results were compared to 42 babies born after normal pregnancies. There were no significant differences in gestational age, birth weight, thoracic gas volume or crying vital capacity. Babies subjected to amniocentesis had a significantly lower dynamic compliance (6.96ml/cm H2O vs. 8.60ml/cm H2O) and tended to have higher resistence compared to controls (52.8 cm H2O/l/s vs. 37.3 cm H2O/l/s). This provides further evidence that mid-trimester amniocentesis does have an adverse effect on lung growth and development.
    Type of Medium: Electronic Resource
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