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  • 1
    Digitale Medien
    Digitale Medien
    Is total abdominal hysterectomy with bilateral salpingo-oophorectomy adequate for new FIGO Stage I endometrial carcinoma? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective The new FIGO staging for endometrial cancer cases complies with other forms of surgical staging and correlates better with clinical outcomes because it includes prognostic factors. This study was done to investigate whether total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO) is adequate for new FIGO Stage I endometrial carcinoma.Subjects Sixty-five cases of endometrial carcinoma defined according to the new FIGO Stage Ia (n= 26), Ib (n= 24) and Ic (n= 15) were analysed. They all received TAH + BSO only and were followed up for at least two years.Methods The histologic type, grade, depth of myometrial invasion, lympho-vascular tumour emboli and tumour size were analysed by t-test to correlate the risk factors for treatment failure.Results There were no recurrences after TAH + BSO in Ia and Ib cases. However, recurrences occurred in five cases (33 %) of Stage Ic with deep myometrial invasion, high histologic grade, large tumour size and tumour emboli.Conclusions TAH + BSO is inadequate in some Ic cases with a high histologic grade, deep myometrial invasion and tumour emboli. Thus, thorough pre-operative and intra-operative staging, adequate operation method and prompt post-operative adjuvant therapy are indispensable for successful treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb09069.x
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  • 2
    Digitale Medien
    Digitale Medien
    Persistent gestational trophoblastic tumour with partial hydatidiform mole as the antecedent pregnancy (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective A 16 year review of persistent gestational trophoblastic tumour when the antecedent pregnancy was a partial hydatidiform mole.Design Cases of persistent gestational trophoblastic tumour with partial hydatidiform mole as the antecedent pregnancy were reviewed for the period 1976 to 1992. DNA ploidy was analysed by flow cytometry.Setting A University Hospital which is a reference centre for gestational trophoblastic tumour.Subjects The case notes of 207 women with persistent gestational trophoblastic tumour were reviewed.Main outcome measures A rise (or failure to fall) of βhCG titre, or sign of metastasis.Results Six (2.9 %) women had partial hydatidiform mole as the antecedent pregnancy and all were initially judged to be low risk. However, two developed pulmonary metastasis; one woman developed persistent gestational trophoblastic tumour shortly after a hysterotomy, and none developed choriocarcinoma. The geometric mean of serum βhCG concentrations at the initiation of chemotherapy was 868mIU/ml (95% CI 114–1524). Of the six women, one achieved remission after total abdominal hysterectomy, and five after chemotherapy. The mean interval from starting treatment to remission was 68 days (95% CI 27.9–108.0). The initial PhCG titre and interval were not statistically different from those found in cases of persistent gestational trophoblastic tumour when the antecedent pregnancy was not partial hydatidiform mole. Of the six, the DNA content was triploid in three and diploid in two. One of the two diploid cases required multiple courses of chemotherapy to achieve remission.Conclusion Partial hydatidiform mole can have malignant sequelae and can develop very soon after treatment. Its DNA content can be either diploid or triploid, the lungs being the most common site of metastasis. After evacuation of partial hydatidiform mole, immediate chest X-ray and regular follow up of the serum βhCG level is necessary.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13620.x
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  • 3
    Digitale Medien
    Digitale Medien
    Comparison of treatment outcomes of imipramine for female genuine stress incontinence (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To assess the efficacy of imipramine as a treatment of genuine stress incontinence and to explore the possible determining factors for treatment success and failure.Design A prospective study.Setting University department of obstetrics and gynaecology.Participants Forty women with genuine stress incontinence were enrolled.Methods Each woman was treated with 25 mg imipramine three times a day for three months.Main outcome measures Each woman had a 20-minute pad test and urodynamic study including uroflowmetry, both filling and voiding cystometry, and stress urethral pressure profile before and after treatment.Results After treatment, 35% (n= 14) were cured, 25% (n= 10) improved by 2 50% and in the remaining 40% (n= 16) treatment failed. The efficacy of successful treatment was 60% (95% CI44.8–75.2). The median age and parity, as well as menopausal status, showed no statistical differences between the two groups. The pre-treatment data including pad weight, functional urethral length, maximal urethral pressure, bladder compliance at urgency, bladder capacity, and average and maximal flow rates showed no statistical differences between the two groups except urethral closure pressure (P= 0.001). Besides, the functional urethral length and urethral closure pressure were significantly improved in the treatment success group. After medication, the median functional urethral length was 3 cm (intraquantile range [IQR] 2.3–3) in the treatment success group vs 2.3 cm (IQR 2–3) in the treatment failure group (P= 0.028). The urethral closure pressure was 77 cmH, O (IQR 61–105) for the treatment success group vs 40 cmH, O (IQR 34–53) in the treatment failure group (P 〈 0.0001).Conclusions The efficacy of imipramine for genuine stress incontinence was 60% (95% CI 44.8–75.2). The pre-treatment high urethral closure pressure may serve as a predictor for treatment success.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08119.x
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  • 4
    Digitale Medien
    Digitale Medien
    The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer (1997)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer.Design A prospective, case-controlled study.Participants Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study.Methods Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI.Main outcome measures All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.Results The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P 〈 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P 〈 0.05) or recurrent cancer (P 〈 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r=−0.622, P 〈 0.0001).Conclusions Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1997.tb10981.x
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  • 5
    Digitale Medien
    Digitale Medien
    Comparison between a two-layer discontinuous Percoll gradient and swim-up for sperm preparation on normal and abnormal semen samples (1995)
    Springer
    Journal of assisted reproduction and genetics 12 (1995), S. 698-703 
    Details
    ISSN: 1573-7330
    Schlagwort(e): sperm ; Percoll gradient ; motility ; morphology ; velocity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose This work was to compare the effects of Percoll gradient and swim-up treatments for sperm preparation on the percentage of progressive motility, recovery of motile sperm, removal of debris, percentage of normal forms according to strict criteria, and movement characteristics of sperm using computer-assisted velocity analysis. Results In total, 50 semen samples from 50 patients were tested and divided into two groups: a normal group (n=27) with normal parameters and an abnormal group (n=23) with abnormal parameters. The results in both the normal and the abnormal groups revealed that the sperm concentration in the Percoll samples was significantly greater than that in the swim-up samples. Although the percentage of progressive motility was greater in the swim-up samples than in the Percoll samples, the number of motile sperm, reflecting the percentage of motile sperm recovery, was still greater in the Percoll samples. The debris of semen were equally removed by both methods and the percentage of normal forms was also similar in the samples treated according to these two procedures. Both curvilinear velocity (VCL) and straight-line velocity (VSL) of sperm were significantly greater in the swim-up samples than in the Percoll samples. Sperm from the swim-up procedure also showed a greater mean amplitude of lateral head displacement than that from the Percoll gradient procedure, but the distinction was insignificant. Conclusion The Percoll gradient technique, by recovering more motile sperm, may be applied to prepare oligospermic samples. The swim-up method may become the standard choice to prepare normal semen which could obtain sufficiently motile sperm, due to its simplicity and recovered sperm with superior motility.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02212896
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of the number and depth of embryos transferred and unilateral or bilateral transfer in tubal embryo transfer (TET) (1992)
    Springer
    Journal of assisted reproduction and genetics 9 (1992), S. 534-538 
    Details
    ISSN: 1573-7330
    Schlagwort(e): tubal embryo transfer ; unilateral and bilateral transfer ; depth of tubal transfer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Methods One hundred eight consecutive TET cycles were analyzed. Oocyte retrievals were carried out by transvaginal ultrasound-guided aspiration of follicles. Forty-eight hours after oocyte retrieval, the developing embryos at the stage of two to four cells were transferred into the fallopian tube(s) by laparoscopy. A maximum of four embryos was transferred to each patient.
    Kurzfassung: Results The pregnancy rates were similar among the cycles in which two, three, or four embryos were transferred. In addition, there was no significant difference in the pregnancy rate whether the embryos were deposited 〉4 cm or between 3 and 4 cm into the tube(s). Although the pregnancy rate was greater in cycles of bilateral tubal transfer, the difference from that of unilateral transfers was not significant.
    Notizen: Purpose Our purpose was to evaluate the possible effects of the number of embryos transferred, the depth of embryos placed within the tube(s), and unilateral or bilateral tubal transfer on pregnancy initiation in tubal embryo transfer (TET).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01204250
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  • 7
    Digitale Medien
    Digitale Medien
    Peptides extracted from vero cell cultures overcome the blastocyst block of mouse embryos in a serum-free medium (1994)
    Springer
    Journal of assisted reproduction and genetics 11 (1994), S. 165-171 
    Details
    ISSN: 1573-7330
    Schlagwort(e): peptides ; coculture ; Vero cell ; blastocyst block ; mouse embryo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose The aim of this work was to evaluate the effect of a Vero cell coculture system on the development of mouse embryos. Methods Mouse embryos were randomly divided and cultured in human tubal fluid (HTF) medium with/without Vero cell monolayers, conditioned medium (CM) obtained from Vero cell cultures, and HTF medium supplemented with peptides extracted from CM. The concentrated CM was examined by SDS/PAGE. Results The development of mouse embryos was blocked at the blastocyst stage in pure HTF medium (1.4% hatching at day 5). This “blastocyst block≓ was overcome by coculture with Vero cell monolayers (48.1% hatching at day 5; 1.4 vs 48.1%; P〈0.001). CM and the addition of 5% fetal bovine serum (24.1 and 34.9% hatching, respectively, at day 5) were also able to enhance the process of hatching. In the other experiment, the addition of peptides extracted from Vero cell cultures also overcame the blastocyst block (12.5%) compared with pure HTF medium (2.1%) (P〈0.05). Electrophoretic separation revealed several classes of polypeptides consistently secreted into CM obtained from Vero cell cultures. Most peptides occurred in the Mr range between 6.5 kd and 35.9 kd. Conclusion A developmental block (blastocyst block) of mouse embryos in a serum- and protein-free medium (HTF) was discovered in this study. This block was effectively overcome by HTF plus serum and coculture with Vero cell monolayers and also by the peptides extracted from Vero cell-conditioned medium. We speculate that certain factors secreted or converted by Vero cells may be critical in hatching of mouse embryos. Further study of these factors may be helpful in delineating its mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02332095
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