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Retinal function and morphology in two zebrafish models of oculo-renal syndromes (2003)

Bahadori, Ronja ; Huber, Matthias ; Rinner, Oliver ; [et al.]

Oxford, UK : Blackwell Science, Ltd

European journal of neuroscience 18 (2003), S. 0

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ISSN: 1460-9568

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: We characterized visual system defects in two recessive zebrafish mutants oval and elipsa. These mutants share the syndromic phenotype of outer retinal dystrophy in conjunction with cystic renal disorder. We tested the function of the larval visual system in a behavioural assay, eliciting optokinetic eye movements by high-contrast motion stimulation while recording eye movements in parallel. Visual stimulation did not elicit eye movements in mutant larvae, while spontaneous eye movements could be observed. The retina proved to be unresponsive to light using electroretinography, indicative of a defect in the outer retina. Histological analysis of mutant retinas revealed progressive degeneration of photoreceptors, initiated in central retinal locations and spreading to more peripheral regions with increasing age. The inner retina remains unaffected by the mutation. Photoreceptors display cell type-specific immunoreactivity prior to apoptotic cell death, arguing for a dystrophic defect. Genomic mapping employing simple sequence-length polymorphisms located both mutations on different regions of zebrafish linkage group 9. These mutants may serve as accessible animal models of human outer retinal dystrophies, including oculo-renal diseases, and show the general usefulness of a behavioural genetic approach to study visual system development in the model vertebrate zebrafish.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02863.x

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Schwingungsrißkorrosionsverhalten des austenitischen Stahles X 6 CrNiMoTi 17 12 2 in 3%iger NaCl-Lösung unter Umlaufbiegebelastung (1992)

Roeder, Erwin ; Bassler, Hans-Jürgen ; Huber, Matthias ; [et al.]

Weinheim [u.a.] : Wiley-Blackwell

Materials and Corrosion/Werkstoffe und Korrosion 43 (1992), S. 426-431

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ISSN: 0947-5117

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Description / Table of Contents: Corrosion fatigue behaviour of the austenitic steel X 6 CrNiMoTi 17 12 2 in 3% NaCl-solution under rotating bending loadThe fatigue behaviour of steel X 6 CrNiMoTi 17 12 2 (German material-number 14571, comparable to AISI 316 Ti) is investigated under rotating bending load with a frequency of 50 Hz. The fatigue strength in inert medium (thermostat oil) at room temperature is 315 N/mm2. In 3% NaCl-solution of pH 7 at the same temperature the corrosion fatigue limit for N = 107 reached only 94% of the mentioned value. A higher temperature (70 °C) caused a further reduction to 89% and an additional decrease of the pH-value (pH 3) lowers the dynamic strength to 86% of the reference value.The free corrosion potential, recorded during all corrosion fatigue tests, remains in the passive region for all specimens, which do not fail under the mechanical-corrosive load. The potential of specimens, which fail under a higher mechanical load, announces their rupture by a sudden decrease to negative values, which starts at least 3·104 cycles (10 minutes) before.

Notes: Das dynamische Verhalten des hochlegierten austenitischen Stahles X 6 CrNiMoTi 17 12 2 (Werkstoff-Nr. 14571) wird unter Umlaufbiegebelastung in chloridionenhaltigen wäßrigen Lösungen mit einer Prüffrequenz von 50 Hz untersucht. Als Korrosionsmedium wird dabei eine luftgespülte 3%ige NaCl-Lösung, eingestellt auf pH 7 bei Raumtemperatur und 70 °C sowie pH 3 bei 70 °C, verwendet. Vergleichsversuche unter inerten Bedingungen in Thermoöl bei Raumtemperatur führen zu einer Dauerschwingfestigkeit von 315 N/mm2. Durch den zusätzlichen Korrosionsangriff sinkt die Zeitschwingfestigkeit für N = 107 um maximal 14%.Bei allen SwRK-Versuchen zeigt sich, daß das während der gesamten Versuchsdauer aufgezeichnete Ruhepotential der oberhalb der 107-Korrosionszeitschwingfestigkeit belasteten Proben unmittelbar vor deren Versagen sehr stark absinkt und dieses Verhalten als Bruchvorankündigung genutzt werden kann.

Additional Material: 7 Ill.