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  • 1
    ISSN: 1432-1017
    Keywords: Key words Cyclopeptide ; Surfactant ; Interaction ; Micelle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The interaction of the cyclic decapeptide antibiotic gramicidin-S (GrS) with the nonionic detergent octaethylene glycol mono-n-dodecyl ether was studied by NMR spectroscopy. Detergent binding led to a slightly altered average conformation in the d-Phe side chains of the peptide. The changing diamagnetic shielding of nearby protons resulted in chemical shift variations, the largest effect being observed for the d-Phe C α proton. The continuous upfield shift of this proton resonance, indicating rapid exchange of the peptide between detergent-associated and unassociated states, was employed for an evaluation of the detergent/peptide aggregation equilibria. The nonlinear binding plot thus obtained was attributed to essentially different aggregational states, depending on the detergent/peptide ratio. The almost linear dependence of the spin-lattice relaxation rate and of the hydrogen-deuterium exchange rate on the fraction of detergent-associated GrS could be reconciled with a simple model, comprising binding of detergent monomers and cooperative binding of micelles at low and high detergent/peptide molar ratios, respectively. Thus, GrS provides a useful model for a study of backbone dynamics and water penetration in detergent- and membrane-bound peptides and proteins. The results will also be discussed with reference to the interaction of GrS with biological membranes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 17 (1993), S. 249-256 
    ISSN: 1432-1009
    Keywords: Fault zones ; Radon-222 ; Soil permeability ; Soil shrink-swell potential ; Surficial geology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Over the last several years, the inhalation of decay products coming from radon-222 has become a national health concern. It is estimated that somewhere between 16,000 and 20,000 people die annually in the United States from lung cancer due to exposure to these decay products. Nationwide, 95% of all homes have not been tested for radon, and so it would seem that any methodology that could give a general idea of indoor radon concentrations (without actually testing the house itself) might be useful. While not intended to replace a radon test, which is both simple and inexpensive, our project attempts to predict indoor radon concentrations based on easily obtainable information from Soil Conservation Service county soil surveys and US Geological Survey surficial geology maps. We have chosen four parameters: soil permeability, surficial geology, soil shrink-swell potential, and distance to the nearest geologic fault. Of these four variables, surficial geology and distance to fault correlated well to winter indoor radon concentrations as measured by short-term (48-h) tests. While it is understood that there are limits to this methodology, primarily because of map scale problems, the correlations mentioned above were very strong and suggest further study would be useful.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 7 (1983), S. 505-510 
    ISSN: 1432-1009
    Keywords: Land use management ; New federalism ; Natural hazards ; Rood control programs ; Avalanche control programs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This article examines the likely impacts of the United States' “new federalism” on natural hazard land use management in Colorado. Flood and avalanche hazard programs are the focus of the study Both short- and long-term effects of changes in funding are discussed, and the conclusions summarize probable positive and negative program impacts for the state. These results may help researchers and state authorities mitigate similar effects in their states prior to the enactment of new federalism.
    Type of Medium: Electronic Resource
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  • 4
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    Ann Arbor, Mich., etc., : Periodicals Archive Online (PAO)
    Journal of Asian Studies. 37:1 (1977:Nov.) 141 
    ISSN: 0021-9118
    Topics: Political Science , Economics
    Description / Table of Contents: "Japan"
    Notes: Book Reviews
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  • 5
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    Unknown
    Macomb, Ill., etc. : Periodicals Archive Online (PAO)
    Journal of Geography. 79:3 (1980:Mar.) 112 
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 258-263 
    ISSN: 1433-8491
    Keywords: Epidural hematoma ; Extradural hemorrhage ; Computerized tomography ; Head injury ; Morbidity/mortality rate ; Epiduralhämatomen ; Computertomographie ; Kopfverletzung ; Mortalitätsrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die katamnestische Untersuchung von 120 Epiduralhaematomen (EDH) je 7 Jahre vor und nach Einführung der Computertomographie (CT) ergab, daß durch das CT zwar eine bedeutende diagnostische Bereicherung und ein relativ geringer Zeitgewinn erfolgte. Ausschlaggebend für die Prognose erwies sich jedoch der Umstand, daß der Arzt auf der Unfallstelle oder im erstversorgenden Krankenhaus die Blutungsgefahr erkannte and eine sofortige Zuweisung ins neurochirurgische Zentrum veranlaßte. Die Bedeutung der ‚typischen’ Frühsymptome des EDH wurde analysiert. Die Wichtigkeit der exponierten temporo-parietalen Schädelfraktur, einer sorgfältigen neurlogischen Überwachung und einer großzügigen CT-Diagnostik wird betont.
    Notes: Summary An analysis of 120 extradural hematomas 7 years before and after introduction of computerized axial tomography (CT) showed that application of this new method resulted in considerable progress in diagnostic accuracy and a small saving of time. It was, however, prognostically decisive that the physician at the site of the accident or in the first-aid unit recognized the risk of imminent bleeding and immediately arranged for transport to the neurosurgical centre. The significance of the “typical” early symptoms of extradural hematomas was analysed. The importance of the exposed temporoparietal skull fracture, of careful neurological supervision and generous diagnostic use of the CT-scan is stressed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of computer aided molecular design 8 (1994), S. 695-708 
    ISSN: 1573-4951
    Keywords: Conformational search ; Computer simulation ; Molecular dynamics ; Cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The concept of memory has been introduced into a molecular dynamics algorithm. This was done so as to persuade a molecular system to visit new areas of conformational space rather than be confined to a small number of low-energy regions. The method is demonstrated on a simple model system and the 11-residue cyclic peptide cyclosporin A. For comparison, calculations were also performed using simulated temperature annealing and a potential energy annealing scheme. Although the method can only be applied to systems with a small number of degrees of freedom, it offers the chance to generate a multitude of different low-energy structures, where other methods only give a single one or few. This is clearly important in problems such as drug design, where one is interested in the conformational spread of a system.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of computer aided molecular design 8 (1994), S. 29-40 
    ISSN: 1573-4951
    Keywords: Structure refinement ; Coupling constant restraints ; Time-dependent restraints ; Ensemble averages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Utilization of coupling constants as restraints in computational structure refinement is reviewed. In addition, we address the effect of conformational averaging and examine different approaches to apply the restraints when the experimental observable is obviously a result of averaging. Here, two different computational methods are compared. The simulation of a single structure with time-dependent restraints produces results very similar to those obtained with the calculation of numerous copies of the molecule (an ensemble of structures) and ensemble averaging. The advantages and disadvantages of the two methods are illustrated with simulations of cyclosporin A, for which 117 NOEs and 62 homo- and heteronuclear coupling constants have been measured.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomolecular NMR 8 (1996), S. 285-291 
    ISSN: 1573-5001
    Keywords: Time-averaged distance restraints ; Weak coupling ; MD simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Application of the weak-coupling scheme to restrain the configurations of a molecular system to a set of NOE distance restraints is investigated using two test systems: (i) a 15-atom chain molecule with one distance restraint; and (ii) a protein molecule with hundreds of NOE distance restraints. Atom-atom distance restraining by the weak-coupling technique is possible, but this method does not produce as good results as the penalty function method normally used to maintain NOE distance restraints.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-5001
    Keywords: J-coupling ; Time averaging ; Structure refinement ; Computer simulation ; Molecular dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary We describe a new penalty function for use in restrained molecular dynamics simulations which allows experimental J-coupling information to be enforced as a time-averaged, rather than instantaneous, quantity. The pseudo-energy term has been formulated in terms of a calculated J value (a measured quantity) rather than the relevant dihedral angle (a derived quantity). This accounts for the distinct non-linearity of the coupling constant with respect to either Cartesian coordinates or dihedral angles. Example simulations of the cyclic decapeptide antamanide show the procedure's ability to enforce experimental restraints while exploring a large region of conformational space and producing a relatively small disturbance of the physical force field.
    Type of Medium: Electronic Resource
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