Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ion channels Accessory to kidney disease (2001)
    [s.l.] : Nature Publishing Group
    Nature 414 (2001), S. 502-503 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Kidneys are filters: they remove waste substances from the bloodstream, producing urine. In so doing, they also regulate various qualities of the blood, such as its salt level. When kidneys malfunction the results can be debilitating, as occurs in Bartter's syndrome, a salt-wasting disorder that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35107186
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    INCREASED CAESIUM SENSITIVITY OF ROMK1 BY MUTATIONS 0F THE PORE RESIDUE GLYCINE 143 (G143) (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.abs174.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    INCREASED BARIUM SENSITIVITY OF ROMK1 BY POINT MUTATIONS 0F GLYCINE 143 (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.abs48.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    RACTK1: a putative inward rectifier potassium channel of the distal nephron. Investigation in Xenopus laevis oocytes (2001)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 6 (2001), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To date, cloning and examination of the functional properties of RACTK1, a K+ channel present in the distal nephron, have been performed in Chinese hamster ovary cells, but not using the oocyte expression system. We examined the expression and cytological localization of RACTK1 protein in Xenopus oocytes. In vitro transcribed cRNA of ROMK1, RACTK1, streptavidin-tagged constructs of RACTK1 and ROMK1, alone or in concert, were injected into oocytes. Protein expression was evaluated by two-electrode voltage clamp, followed by immunocytochemistry. ROMK1 and co-injected oocytes (tagged and untagged) exhibited barium-sensitive K+ conductances significantly greater than both RACTK1 (tagged and untagged) and water-injected oocytes. Water-injected oocytes failed to demonstrate protein expression. Expression of membrane protein was evident in ROMK1-injected and RACTK1/ROMK1 co-injected oocytes, but not in RACTK1-injected oocytes. RACTK1 does not produce an extracellular membrane protein in oocytes. Therefore, this system is not suitable for further study or verification of the properties of RACTK1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2001.00071.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    INCREASED BARIUM SENSITIVITY OF ROMK1 BY POINT MUTATIONS 0F GLYCINE 143 (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.abs134.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    INCREASED CAESIUM SENSITIVITY OF ROMK1 BY MUTATIONS 0F THE PORE RESIDUE GLYCINE 143 (G143) (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.abs92.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Multi-barrelled K channels in renal tubules (1987)
    [s.l.] : Nature Publishing Group
    Nature 327 (1987), S. 522-524 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The diluting segment of amphibians and mammals reabsorbs sodium chloride in excess of water4'5. The uptake of sodium and chloride into the cell from the tubule lumen is through the furosemide-sensitive Na+, K+, 2Cr-cotransporter. However, the delivery of potassium by the tubule to this segment is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/327522a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Calcium-activated K-channels ofAmphiuma early distal tubule: inhibition by ATP (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 331-333 
    Details
    ISSN: 1432-2013
    Keywords: diluting segment ; potassium channels ; ATP inhibition ; calcium-sensitivity ; AMP-PNP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582517
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Calcium-activated potassium channels in the luminal membrane of Amphiuma diluting segment: voltage-dependent block by intracellular Na+ upon depolarisation (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 422-427 
    Details
    ISSN: 1432-2013
    Keywords: Kidney ; Furosemide ; Early distal tubule ; Amphibian ; Potassium channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcium-activated potassium channels in the luminal membrane of Amphiuma diluting segment were studied using the patch-clamp technique in both the cellattached and inside-out configurations. The open probability (P o) of the channel is sensitive to both membrane potential and cytoplasmic calcium activity; depolarizing potenials and high calcium concentrations leading to an increased P o. In the cell-attached condition, channel openings were observed between pipette potentials of −100 and −240 mV. As the driving force for potassium exit from the cell into the pipette is increased the single channel currents show a biphasic response. First, the currents increase as expected; however, the single channel currents diminish in magnitude at pipette potentials more negative than −120 mV. We propose that this reduction is due to rapid blockade of the potassium channel by intracellular sodium. This proposal is supported by two facts: (a) using inside-out patches it was possible to reduce the single channel currents in a concentration- and voltage-dependent manner, similar to that observed in the cell-attached condition, by raising the sodium concentration of the fluid bathing the cytoplasmic face of the patch; (b) pretreatment of tubules with the loop-acting diuretic furosemide (10−5M), an agent known to decrease the intracellular sodium activity, caused an attenuation of the reduction in single channel current seen under control conditions. Given the very low P o of the channels at the resting membrane potential and the sensitivity of the channels to intracellular sodium, it is unlikely that blockade of these channels by intracellular sodium would lead to a physiological regulation of the apical K conductance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370749
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Stretch-activated channels in the basolateral membrane of single proximal cells of frog kidney (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 448-453 
    Details
    ISSN: 1432-2013
    Keywords: Stretch activation ; Cell volume regulation ; Voltage dependence ; Patch clamp ; Proximal tubule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Epithelial cells are capable of regulating their volume in response to osmotic swelling or shrinkage. In the present paper a channel is described which may be involved in such a volume-regulatory response. Channels were studied in cell-attached patches of the basolateral membrane of cells isolated from frog kidneys using the patch-clamp technique. The open probability of the channels is increased by the application of negative pressure to the rear of the patch pipette or by bathing the cells in hypotonic fluid. In addition, the channels are voltagesensitive, such that depolarisation increases the open probability. The channels have a conductance of 25 pS with amphibian Ringer as the pipette solution and appear not to discriminate between potassium and sodium. Replacement of chloride by gluconate as the dominant anion in the pipette solution did not affect the current/voltage relationship, suggesting that the channels are cation-nonselective. Inward currents are observed at the resting membrane potential with either potassium or sodium as the dominant cation in the pipette solution: this obviates the channels serving a role as the route for solute exit from the cell during a volume-regulatory decrease response and suggests that they may act as the transduction mechanism sensing changes in cell volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370753
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...