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RESEARCH REPORT Psychiatric co-morbidity among male heroin addicts: differences between hospital and incarcerated subjects in Taiwan (1999)

Chen, Chiao-Chicy ; Tsai, Shang-Ying ; Su, Lien-Wen ; [et al.]

Oxford, UK : Carfax Publishing, Taylor & Francis Ltd

Addiction 94 (1999), S. 0

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ISSN: 1360-0443

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine , Psychology

Notes: Aims. To examine the differences in psychiatric co-morbidity between hospital and incarcerated groups of heroin addicts in Taiwan. Design. Life-time prevalence of DSM-III-R-based coexisting psychiatric disorders, including personality disorders, were surveyed. Settings. A psychiatric hospital and two prisons. Participants. Two hundred and sixty heroin users who were incarcerated in prisons, and 47 heroin users who voluntarily sought help in a psychiatric hospital were interviewed by board-certified psychiatrists. Measurements. Using two psychometric instruments, the Psychiatric Diagnostic Assessment (PDA) and the Structured Interview for DSM-III-R Personality Disorders (SIPD-R), psychiatric co-morbidity was assessed. Findings. Different life-time rates of coexisting psychiatric disorders among heroin addicts in different settings were found: 83% of hospital subjects and 66% of incarcerated subjects were diagnosed as having at least one coexisting axis I or II disorder. The most prevalent coexisting DSM-III-R defined axis I disorders were additional substance use disorders (alcohol and methamphetamine), while the axis II disorder was antisocial personality disorder. The hospital group had a significantly higher prevalence rate of mood disorder (p〈0.001), paranoid personality disorder (p〈0.05) and antisocial personality disorder (p〈0.001) than the incarcerated group. Conclusions. We suggest that heroin addicts with coexisting psychiatric disorders receive relevant psychiatric treatment. Those with personality disorders, especially the antisocial type, should be considered for specialized therapeutic community programmes instead of incarceration .

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1360-0443.1999.9468256.x

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Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations (1997)

Lin, M.-W. ; Sham, P. ; Hwu, Hai-Gwo ; [et al.]

Springer

Human genetics 〈Berlin〉 99 (1997), S. 417-420

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ISSN: 1432-1203

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Previously we reported suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1–q32. We have now studied an additional independent sample of 44 pedigrees consisting of 34 Taiwanese, 9 English and 1 Welsh family in an attempt to replicate this finding. Narrow and broad models based on Research Diagnostic Criteria or the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised, were used to define the schizophrenia phenotype. Under a dominant genetic model, two-point lod scores obtained for most of the markers were negative except that marker D13S122 gave a total lod score of 1.06 (θ = 0.2, broad model). As combining pedigrees from different ethnic origins may be inappropriate, we combined this replication sample and our original sample, and then divided the total sample into Caucasian (English and Welsh pedigrees) and Oriental (Taiwanese and Japanese pedigrees) groups. The Caucasian pedigrees produced maximized admixture two-point lod scores (A-lod) of 1.41 for the marker D13S119 (θ = 0.2, α = 1.0) and 1.54 for D13S128 (θ = 0, α = 0.3) with nearby markers also producing positive A-lod scores. When five-point model-free linkage analysis was applied to the Caucasian sample, a maximum lod score of 2.58 was obtained around the markers D13S122 and D13S128, which are located on chromosome 13q32. The linkage results for the Oriental group were less positive than the Caucasian group. Our results again suggest that there is a potential susceptibility locus for schizophrenia on chromosome 13q14.1–q32, especially in the Caucasian population.