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  • 1
    ISSN: 1573-2568
    Keywords: PROBIOTICS ; LACTOBACILLUS ; CLOSTRIDIUM ; INTESTINE ; CELL DIVISION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Probiotics are used for various intestinaldiseases. However, their effects on gut epithelial cellproliferation have not been investigated. Weadministered 107 colony-forming units ofLactobacillus casei or Clostridium butyricum , or no probiotics(control) by gastric intubation once a day for sevendays to rats fed an elemental diet. We estimated thecrypt cell production rate of the jejunum, ileum, cecum, and distal colon. We also quantified cecalbacteria. Both probiotics increased the crypt cellproduction rate of the jejunum and ileum by 25-40%, ofthe cecum by 70%, and of the distal colon by more than 200% compared with control. Only minor variancein the cecal bacterial composition existed among thethree groups. Probiotics enhanced gut epithelial cellproliferation in rats fed an elemental diet.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 42 (1997), S. 1598-1610 
    ISSN: 1573-2568
    Keywords: L-LACTATE ; SHORT-CHAIN FATTY ACIDS ; PROTON LOAD ; LARGE INTESTINE ; CELL PROLIFERATION ; MORPHOMETRY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the influences of cecal infusion ofNaCl, short-chain fatty acids (SCFA), and L-lactic acidat pH 5.0 or 7.0 for seven days on morphometric and cellkinetic parameters of the rat cecum. SCFA increased relative weight of the mucosa andsubmucosa, crypt size, and mitotic index in the cecum.L-Lactic acid stimulated mitosis only at pH 5.0. Cryptsize correlated positively to epithelial proliferative activity only when NaCl or L-lactic acid wasinfused. SCFA should have changed the balance betweenproduction and loss of the cecal epithelial cells. Theinfusate pH by itself had no effect, but modified the effects of SCFA and L-lactic acid indifferent ways. Crypt size correlated positively to thelogarithm of daily proton load of infusates. The aboveresults indicate that epithelial cell proliferation in the cecum is influenced by both SCFA andL-lactic acid, although differently, and by protonload.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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