ISSN:
1432-0428
Keywords:
Chronic (maturity onset) diabetes mellitus
;
glucose tolerance
;
insulin and growth hormone secretion
;
intermediary metabolites
;
lipids
;
diet treatment
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Thirty-five freshly presenting, diabetic patients received 5 hour, 100 g oral glucose tolerance tests when first seen and after a period of carbohydrate and energy restriction. After treatment, the significant improvement in glucose tolerance was accompanied by increased insulin secretion and lower concentrations of blood ketone bodies, lactate, glycerol, FFA, triglycerides, cholesterol and pre-beta lipoprotein. There were no significant changes in serum growth hormone or blood pyruvate concentrations. Improvement in glucose tolerance was greater in patients who were obese (〉115% of desirable body weight for height) on presentation and was related to the improvement in insulin secretion and the diminished lipolysis. An hypothesis to explain the changes in insulin secretion is proposed. Eleven out of the 35 patients showed sufficient improvement in glucose tolerance to require no treatment other than diet.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01236315
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