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  • 1
    Electronic Resource
    Electronic Resource
    Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders (1967)
    Springer
    Experimental brain research 3 (1967), S. 195-211 
    Details
    ISSN: 1432-1106
    Keywords: Regional cerebral blood flow man ; Mental activity ; Hemisphere lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regional cerebral blood flow (rCBF) was recorded simultaneously in four circumscribed hemisphere regions in 30 subjects in double determinations by means of the intra-arterial 133Xenon clearance technique. Group I was a control group of 10 subjects. Group II consisted of 12 subjects of which 4 were normals and 8 were patients without signs of organic local or diffuse cerebral disorders. Group III consisted of 8 patients with localized hemisphere lesions. During one of the rCBF measurements, the subjects in Groups II and III were asked to perform a digit-span-backward test. In Group II the test gave rise to a small but significant increase in rCBF which averaged about 2.2 ml/100 g/min in mean rCBF, i. e. an increase of about 5 %, and 5.7 ml/100 g/min for gray matter flow, i.e. an increase of 8%. This increase was most evident in “suprasylvian” parts of the hemisphere. An increase in rCBF was also found in Group III with focal cerebral lesions. In four cases with circumscribed lesions which all involved superficial parts of the hemisphere, only small or no changes were seen during mentation within the lesions, and some marked augmentations outside the pathologic areas. The augmentation of rCBF during the test probably reflects more or less regional functional (metabolic) accompaniments to mentation. It is likely that both general changes of the ‘arousal’ type, as well as localized gray matter changes take part in these events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235584
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  • 2
    Electronic Resource
    Electronic Resource
    Correlation between cerebral blood volume and cerebral blood flow in the cat (1969)
    Springer
    Experimental brain research 8 (1969), S. 321-326 
    Details
    ISSN: 1432-1106
    Keywords: Cerebral blood volume ; Cerebral blood flow ; Isotope measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood flow and blood volume were measured simultaneously in the same cerebral region in anaesthetized cats with controlled respiration. The measurements were made with the same scintillation-detector, using the freely diffusible indicator 133 Xenon for flow determinations and the intra-vascular indicator RISA (131I) for volume recordings. A very high correlation was found between volume and flow changes (r = .96, p 〈 0.001). This finding indicates that variations of regional cerebral blood volume are accompanied by proportional blood flow changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234379
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  • 3
    Electronic Resource
    Electronic Resource
    EEG frequency content related to regional blood flow of cerebral cortex in cat (1968)
    Springer
    Experimental brain research 5 (1968), S. 55-60 
    Details
    ISSN: 1432-1106
    Keywords: EEG frequency ; Regional cortical blood flow ; Isotope measurements ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The EEG frequency content in cats, anaesthetized by Nembutal and artificially ventilated, was altered by means of injections of either additional Nembutal or of Metrazol. The EEG in cerveau isolé preparations was also changed in the same way. The regional cortical blood flow was determined by means of the 85Krypton technique. A high correlation was found between the frequency content of the EEG, measured by means of manual frequency analysis, and the regional cortical blood flow. The cortical blood flow increased when the mean frequency increased, and vice versa. A similar correlation was found when the EEG mean frequency was changed by means of sensory stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239905
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  • 4
    Electronic Resource
    Electronic Resource
    Regional changes in cerebral blood volume during mental activity (1968)
    Springer
    Experimental brain research 5 (1968), S. 72-78 
    Details
    ISSN: 1432-1106
    Keywords: Mental activity in man ; Regional cerebral blood volume ; Isotope measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten human subjects were injected intravenously with a non-diffusible gamma-emitting isotope. At steady state, 8 collimated scintillation detectors, placed laterally to the subject's head, measured the activity in 8 hemisphere regions. During various types of psychological tests, regional variations in the gamma radiation were recorded. Different patterns of changes were seen during reception of visual impulses, and during various cognitive tasks. These patterns probably represent changes in cerebral blood volume, which are caused by regional metabolic and circulatory events, mainly in the cerebral cortex, and which have a relation to mental activity. Previously demonstrated changes in regional cerebral blood flow during mentation highly support this interpretation. The untraumatic method used in the present study permits, for the first time, continuous extracranial measurements of regional cerebral circulatory events related to mentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239907
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  • 5
    Electronic Resource
    Electronic Resource
    Elimination by hypoxia of cerebral blood flow autoregulation and EEG relationship (1968)
    Springer
    Experimental brain research 5 (1968), S. 61-71 
    Details
    ISSN: 1432-1106
    Keywords: EEG frequency ; Regional cortical blood flow ; Isotope measurements ; Effects of hypoxia ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The relationship between cortical blood flow and the frequency content of the EEG was studied in a circumscribed area of the exposed cerebral cortex in cats under nitrous oxide-oxygen anaesthesia. Autoregulation of the cortical blood flow was also tested during step-changes of the arterial blood pressure. Observations were made before and after an episode of severe hypoxia. 2. An episode of systemic hypoxia disrupted the normal high correlation between cortical blood flow and EEG frequency content. In the post-hypoxic period cortical flows of up to about three times normal values were recorded together with brain swelling and a slow wave EEG. The hyperemia and swelling subsided during 1–2 h after the hypoxic episode, and were accompanied by partial or complete recovery of the EEG. In the post-hypoxic period a defective autoregulation of the cortical blood flow to changes in the systemic blood pressure was demonstrated. 3. The cerebral post-hypoxic state with hyperaemia, brain swelling, EEG depression, and loss of autoregulation of blood flow, is probably caused by an accumulation of anaerobic metabolites which lead to cerebral tissue acidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239906
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  • 6
    Electronic Resource
    Electronic Resource
    Language Functions Related to Prefrontal Cortical Activity: Neurolinguistic Implications (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 682 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb22972.x
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  • 7
    Electronic Resource
    Electronic Resource
    RESPIRATORY REGULATION IN SLEEP (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 109 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb13512.x
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  • 8
    Electronic Resource
    Electronic Resource
    SURVIVAL AFTER SEVERE CEREBRAL ANOXIA WITH DESTRUCTION OF THE CEREBRAL CORTEX: THE APALLIC SYNDROME (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 315 (1978), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1978.tb50339.x
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  • 9
    Electronic Resource
    Electronic Resource
    rCBF landscapes during motor performance and motor ideation of a graphic gesture (1988)
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1988), S. 33-38 
    Details
    ISSN: 1433-8491
    Keywords: rCBF ; 133Xenon inhalation ; Motor ideation ; Neuropsychology ; Cognitive/motor processes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The regional cerebral blood flow (rCBF) distribution was measured by 133xenon inhalation using a gamma camera in 18 right-handed volunteers, 6 subjects performing a graphic task (writing numbers in letters) with the right hand, 6 subjects imagining the same task, and 6 subjects were assessed during two rest periods to determine the reproducibility of the technique. The mean rCBF increased between 10% and 25% (P〈0.01) during both motor performance and motor ideation. However, there were regional differences. While motor performance activated mainly the rolandic regions bilaterally, motor ideation gave prefrontal and premotor rCBF augmentations. In both situations there was significant bilateral increase in regions corresponding to the cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381078
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of a new butyrophenone derivate (Buronil®) on nocturnal sleep in normal man (1975)
    Springer
    Psychopharmacology 43 (1975), S. 95-99 
    Details
    ISSN: 1432-2072
    Keywords: Butyrophenone Derivate (Buronil®) ; Sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nocturnal sleep was studied in eight young normal volunteers (3 female and 5 male students) with polygraphic technique during 2 periods of 10 nights each. After 2 adaptation and 2 baseline nights with placebo, they were given methylperone (Buronil®) 10 or 50 mg per night during three nights and then again placebo for three withdrawal nights. The study was made double blind. The scoring of the records was done according to the manual by Rechtschaffen and Kales (1968). No changes of sleep stages were seen during the drug periods. The lower dose gave an increase of sleep latency but a decrease of number of awakenings during the night. An increase of REM-periods was shown after 50 mg and also a decrease of REM-latency and REM-density. The only significant change during withdrawal periods was a decrease of REM-sleep after methylperone 50 mg, so there was no “barbiturate type” of withdrawal. The change was also different from that of chlorpromazine, which has no clear rebound effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437622
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