Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 44 (1995), S. 493-500 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Kontinuierliche Herzzeitvolumenmessung ; Pulskonturmethode ; kritisch Kranke ; hämodynamisches Monitoring ; Key words Continuous cardiac output ; Haemodynamic monitoring ; Intensive care patients ; Pulse contour analysis ; Vasoactive agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Pulse contour cardiac output (PCCO) is an easily applicable method for continuous measurement of cardiac output in critically ill patients. Calculation of stroke volume is possible by analysing the area under the systolic part of the arterial pulse pressure waveform together with an individual calibration factor (Zao) to account for the individually variable vascular impedance. Since vascular impedance is potentially affected by altered vascular tone, it was the aim of the present study to examine the validity of PCCO in ICU patients receiving various dosages of a variety of vasoactive drugs. Patients and methods. Continuous cardiac output was measured in 20 ICU patients for a total of 110 h using the pulse contour method. The precision of PCCO was determined in comparison with its calibration reference, the thermodilution method (TDCO): (1) during administration of vasoactive drugs at a constant rate and (2) during conditions with altered vascular tone and haemodynamics elicited by changes in vasoactive drug dosage. For this purpose, the patients received varying dosages of vasoactive drugs (dopamine, dobutamine, epinephrine, norepinephrine, nitroglycerin, prostacycline and urapidil). Results. A total of 165 data sets was obtained, each consisting of the average of four capnometrically triggered TDCO measurements and the corresponding PCCO values. The relative difference between methods (±2 SD) was ±23.9% (SD 0.85 l ·min−1; r=0.93) if a single calibration at the beginning of measurement series was performed (Fig. 2). The bias of the mean cardiac output values of both methods was −0.09 l·min−1. The precision of PCCO improved to ±15.7% by additional calibrations (SD 0.56 ·min−1; r=0.96; bias 0.003 l·min−1). Data of two patients showed that recalibration may be necessary after extreme haemodynamic changes due to septic shock or cooling. Alteration of vascular tone by clinically used dosage of vasoactive drugs, however, had no destabilizing effect on the pulse contour method. Conclusions. It could be demonstrated that PCCO provides a valuable method for continuous cardiac output measurement in the intensive care setting with a precision comparable to that of thermodilution.
    Notes: Zusammenfassung Die Pulskonturanalyse ist ein einfach anzuwendendes Verfahren zur kontinuierlichen Bestimmung des Herzzeitvolumens (PCCO) bei kritisch kranken Patienten. Die Berechnung des Schlagvolumens erfolgt über die Analyse der arteriellen Pulsdruckkurve zusammen mit einem für jeden Patienten mittels Referenzverfahren individuell zu bestimmenden Kalibrationsfaktor. PCCO wurde an 20 Intensivpatienten über eine Gesamtzeit von 110 h gemessen und mit Thermodilutionswerten (TDCO) verglichen. Die relative Abweichung (±2 SD) von PCCO gegenüber TDCO wurde ermittelt: (1) unter hämodynamisch stabilen Bedingungen, und (2) unter Bedingungen von verändertem Vasotonus und Hämodynamik bei Dosisänderungen vasoaktiver Substanzen. Insgesamt wurden an 165 Meßzeitpunkten TDCO-Messungen durchgeführt und die korrespondierenden PCCO-Werte registriert. Die relative Abweichung von PCCO gegenüber TDCO betrug ±23,9% (SD=0,85 l·min −1 ), wenn die PCCO-Methode einmalig bei jedem Patienten vor Beginn der Meßserien kalibriert wurde. Die Differenz der Mittelwerte der Herzzeitvolumina (CO) beider Methoden (Bias) war dabei −0,09 l·min −1 . Durch zusätzliche Kalibrationen konnte die relative Abweichung (±2 SD) auf ±15,7% verbessert werden (SD= 0,56 l·min −1 ; Bias 0,003 l·min −1 ). Änderungen in der Dosierung vasoaktiver Substanzen in klinisch üblichen Größenordnungen hatten keinen Einfluß auf die Meßgenauigkeit von PCCO. Es konnte gezeigt werden, daß die Pulskonturanalyse ein leicht anzuwendendes und klinisch ausreichend genaues Verfahren zur kontinuierlichen Messung des CO darstellt.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1435-1803
    Keywords: Key words Heart function –α‐adrenergic receptors –β‐adrenergic receptors – angiotensin II receptors – calcium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We developed a method for measuring left ventricular maximal isovolumetric pressure (LVMIP) in intact rats and applied it in the presence of acutely administered antihypertensive drugs and in experimental diabetes mellitus. The combination of a 2 French Fogarty® arterial embolectomy balloon catheter with a new ultra‐thin shaft (0.25 mm diameter) Millar® ultraminiature pressure tip catheter was used. Closed‐chest, thiopental anaesthetized female Sprague‐Dawley rats received the β‐adrenoceptor blocker metoprolol (1 mg/kg/h), the α‐adrenoceptor blocker prazosin (0.1 mg/kg/h), and the calcium antagonist nifedipine (0.5 mg/kg/h). They were applied as continuous i.v. infusion for 30 minutes. The angiotensin II type 1 (AT1) receptor antagonist losartan (3 mg/kg) was applied as bolus i.v. injection. Diabetes mellitus was induced by a single tail vein injection of streptozotocin (60 mg/kg) five weeks prior to hemodynamic measurements. Under control conditions, left ventricular systolic pressure (LVSP) was 136.5 ± 3.7 mmHg and increased to 263 ± 5.4 mmHg when the balloon was inflated (LVMIP). LVSP was significantly lower in the presence pf prazosin, metoprolol, nifedipine, and in diabetic rats. However, LVMIP was significantly reduced only in the metoprolol‐treated and diabetic rats. Both LVSP and LVMIP did not change significantly in losartan‐treated rats. The degree of the increase in left ventricular maximal isovolumetric pressure during balloon inflation (LVMIP‐LVSP) was not significantly different in any experimental condition. These results suggest that the mechanism for evoking LVMIP is not dependent on the acute stimulation of cardiac α‐ and β‐adrenergic receptors, on calcium channels, nor on the AT1 receptors. In addition, the intrinsic mechanism for the generation of LVMIP seems not to be influenced in the diabetic state.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...