ISSN:
1662-9752
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Since preferential orientation of c-axis of biological apatite (BAp) crystallites dependsstrongly on the shape of hard tissue, closely relating to the in vivo stress distribution, it is a usefulparameter to judge the bone quality. In this study, preferential alignment of BAp crystallites in originaland regenerated hard tissues were analyzed by the micro-beam X-ray diffractometer (μ-XRD) with abeam spot of 50 or 100 μm in diameter. Regenerating processes of bone defects introduced artificiallyin the rabbit ulna or skull were healed by inserting a biodegradable gelatin hydrogel incorporatingbasic fibroblast growth factor-2 (FGF-2).Recovery of BAp orientation alignment depends strongly on the regenerated portion and period,which is insufficient to recover the original level, while bone mineral density (BMD) is almostimproved to the original level. This means that BMD recovers prior to improvement of the BAporientation and the related mechanical function in the regenerated tissues. Thus, reloading on theregenerated portion caused by BMD restoration is suggested to accelerate to produce the appropriateBAp preferential alignment due to the remodeling process.The BAp orientation was finally concluded to be one of the most important indices to check theregenerative degree and process in the regenerated bone under the tissue engineering technique
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/14/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.539-543.675.pdf
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