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  • 1
    Electronic Resource
    Electronic Resource
    Metabolic profiles of organic acids from human plasma (1982)
    s.l. : American Chemical Society
    Analytical chemistry 54 (1982), S. 29-32 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00238a011
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reduction of keto acids and differentiation between isomers by chemical ionization mass spectrometry (1980)
    s.l. : American Chemical Society
    Analytical chemistry 52 (1980), S. 49-52 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50051a013
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The use of iridium-191m for pulmonary blood flow imaging (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 427-431 
    Details
    ISSN: 1619-7089
    Keywords: Iridium-191m ; Pulmonary blood flow imaging ; Technetium-99m macroaggregated albumin ; First-pass radionuclide angiocardiography ; Lung disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A preliminary evaluation of the potential utilisation of osmium-191/iridium-191m for pulmonary blood flow imaging was performed. This evaluation was part of a more general study concerning the use of 191mIr for first-pass radionuclide angiocardiography (FPRNA). In eight selected patients with suspected pulmonary disease, we generated, from the data collected during FPRNA, an image representing blood flow distribution to the lungs. A software program was developed in order to differentiate the lungs from the heart, to define the wash-in lung phase and finally to construct an image representing pulmonary blood flow distribution. We compared that image with a standard lung perfusion image using technetium-99m macroaggregated albumin (MAA) and plain chest X-ray and computerized tomography (CT). The obtained 191mIr perfusion images showed a spatial activity distribution similar to that seen on 99mTc-MAA lung perfusion scans, and in most cases the same perfusion defects. Disease revealed by plain chest X-ray and CT was nicely correlated with perfusion defects seen on the 191mIr images. The combined information of lung perfusion and dynamic cardiac parameters obtained by FPRNA (right and left ventricular ejection fractions) added another relevant dimension to the clinical picture of patients with pulmonary embolism, chronic obstructive lung disease, lung tumour or suspected congestive heart failure. We conclude that 191mIr may become a practical tool for achieving the conceptually promising approach of combined lung-heart real-time imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171418
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Screening of organic acids in urine by chemical ionization mass spectrometry (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 47-56 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method has been developed for qualitative screening of carboxylic acids in human urine. The method uses direct chemical ionization mass spectrometry with isobutane as reagent gas. The carboxylic acids are separated from the urine samples by ion exchange. Normal carboxylic acid profiles have been determined and are compared with the profiles of patients suffering from certian metabolic disorders.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060203
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative profiling analysis of organic acids in complex mixtures (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 436-439 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The simultaneous detection and quantitative determination of a very large number of metabolites in physiological fluids or tissues, and the subsequent comparison of these data with reference values, is a process which has commonly been called “metabolic profiling” analysis. Profiles generated by gas-liquid chromatography on packed or capillary columns are readily analyzed by mass spectrometry, utilizing reverse library search procedures to identify individual components. Emphasis will be given here to procedures for the pre-purification of organic acids from plasma, to the use of quartz capillaries for metabolic profiling analysis, and to the sensitivity of this method for trace components.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200080915
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    Paper (German National Licenses)
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