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  • 1
    Digitale Medien
    Digitale Medien
    Characterization of depolarization induced by palytoxin and grayanotoxin-I in isolated cardiac tissues from dogs and guinea pigs (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 330 (1985), S. 67-73 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Palytoxin ; Grayanotoxin-I ; Na channel ; Na+, K+-ATPase ; Cardiac tissues
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The mode of depolarizing action of palytoxin (PTX) was compared with that of grayanotoxin-I (GTX-I) to examine the site of action of PTX in cardiac tissues isolated from dogs and guinea pigs: 1. PTX at above 1×10−10 mol/l depolarized the membrane of canine Purkinje fibres, canine and guinea-pig ventricular muscles regardless of stimulation. The PTX-induced depolarization was resistant to 1×10−5 mol/l tetrodotoxin (TTX) but was attenuated by low Na medium. 2. GTX-I at 1×10−5 mol/l depolarized the membrane of ventricular muscles from dogs and guinea pigs only when they were stimulated. Although GTX-I caused depolarization in Purkinje fibres in both stimulated and rested conditions, the effect was greater in stimulated fibres. In the presence of GTX-I, ventricular muscles generated long-lasting action potentials as a response to stimuli. TTX antagonized the GTX-I-action. 3. After treatment of PTX, GTX-I still induced the long-lasting action potential and TTX could antagonize it. 4. Ouabain at 1×10−6 or 3×10−6 mol/l partially inhibited the PTX-induced depolarization in guinea-pig papillary muscles. The data suggest that the TTX-sensitive Na channel is intact after treatment with PTX and that PTX acts on a site different from the Na channel, possibly on the Na+, K+-ATPase in cardiac cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00586711
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  • 2
    Digitale Medien
    Digitale Medien
    Properties of palytoxin-induced whole cell current in single rat ventricular myocytes (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 344 (1991), S. 247-251 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Palytoxin ; Whole cell clamp ; Cardiac glycoside ; Rat ventricular cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We examined the properties of the current induced by palytoxin in single ventricular cells of rats. The current was measured by a whole cell voltage clamp method. When the cell was held at −75 mV, palytoxin induced a sustained inward current in a concentration-dependent manner (2–100 pmol/1). The time-course of the inward current paralleled that of the depolarization. At a holding potential of + 50 mV, it caused an outward current. Palytoxin-induced current reversed at 0mV and its current-voltage relation was almost linear at either negative or positive voltage. Substitution of external NaCl with choline-Cl suppressed the palytoxin-induced inward current but not the outward current, by shifting the reversal potential to levels more negative than − 50 mV A cardiac glycoside, cymarin (10 and 100 μmol/l) partially inhibited the palytoxin-induced current without changing the reversal potential, only when applied before palytoxin. Palytoxin decreased the nicardipine-sensitive Ca 2+ current. These data suggest that palytoxin-induced inward current is carried by extracellular Na+ and the outward current is carried mainly by intracellular K+, and that the inward current is responsible for the toxin's depolarizing action. The antagonism by cysmarin indicates that the site of action of palytoxin is in the vicinity of the binding site of cardiac glycosides.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00167226
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  • 3
    Digitale Medien
    Digitale Medien
    Palytoxin induces a nonselective cation channel in single ventricular cells of rat (1988)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 337 (1988), S. 591-593 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Palytoxin ; Nonselective cation channel ; Patch-clamp ; Heart ventricular cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Palytoxin (PTX) causes a depolarization in every excitable tissue tested. We examined whether PTX induces a channel current, which might be responsible for the depolarizing action, in single ventricular cells from rat hearts using a patch-clamp technique. In cell-attached configuration, when PTX (30 pmol/1) was present in a patch pipette, a single channel current appeared, which was different from currents through known channels. When the major cation in the pipette was Na+, the amplitude of the unitary current at the resting potential level was 0.74 ± 0.05 pA, the slope conductance was 9 pS and the reversal potential was 79 mV positive to the resting potential. The channel was little selective between cations because it was permeable not only to Na+ but also to K+, Cs+ and Li+ although it practically did not permit the passage of choline+, TEA+, Bat+ and Ca2+. Thus PTX induces a novel, nonselective cation channel in cardiac cells, which may result in a depolarization.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00182738
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  • 4
    Digitale Medien
    Digitale Medien
    Endothelium-dependent relaxant action of platelet activating factor in the rat mesenteric artery (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 68-73 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Platelet activating factor (PAF) ; Endothelium ; Endothelium-dependent relaxation ; EDRF ; Rat mesenteric artery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Vasorelaxant action of platelet activating factor (PAF) was examined in perfused mesenteric vascular beds and mesenteric artery strips isolated from rats. PAF caused a dose-dependent vasodilation of norepinephrine-contracted mesenteric vascular bed, which was sensitive to CV-3988, a PAF antagonist, but insensitive to tetrodotoxin, atropine, propranolol and indomethacin. PAF also caused a relaxation of phenylephrine-contracted mesenteric artery strips at above 3 × 10−12 M. Much higher concentrations of PAF were required to relax the aorta, carotid and pulmonary arteries. The PAF- and acetylcholine (ACh)-induced relaxations of mesenteric artery were dependent on the presence of endothelium and were inhibited by either hydroquinone and methylene blue, which inhibit the action of endothelium-derived relaxing factor (EDRF), or L-canavanine, which inhibits the formation of nitric oxide from l-arginine. Phospholipase AZ inhibitors such as quinacrine and ONORS-082 abolished the relaxation induced by ACh but did not affect that by PAF. Thus, PAF induces a vasorelaxation by releasing EDRF from endothelial cells as ACh does, although the pathway to produce the substances by PAF may be different from that by ACh.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00195060
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  • 5
    Digitale Medien
    Digitale Medien
    Venenendothelien bei malignen Tumoren (1971)
    Springer
    Surgery today 1 (1971), S. 155-160 
    Details
    ISSN: 1436-2813
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Polynuclear giant entothelial cells were frequently seen in venous endothelium of malignant tumors but almost scarcely in benign cases. The fact will be of help in early recognition of tumor malignancy.
    Notizen: Zusammenfassung Bei abführenden Venen von malignen Tumoren lassen sich mehrkernige Riesenendothelzellen nachweisen, dagegen bei solchen von benignen Tumoren und Magenduodenalgeschwüren fast nicht. Diese Spezifität wird zur frühzeitigen Beurteilung der Malignität des Tumors dienen. (Herrn a.o. Professor Dr. E. Ito, Pathologisches Institut der hiesigen Universität, danken wir sehr für ständige Anleitung.)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02468897
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  • 6
    Digitale Medien
    Digitale Medien
    Ein Fall von cystischer Adventitia-Degeneration der Arteria brachialis (1980)
    Springer
    Surgery today 10 (1980), S. 168-172 
    Details
    ISSN: 1436-2813
    Schlagwort(e): cystic adventitial degeneration ; brachial artery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Ein 51jähriger Patient mit akuter Total-okklusion der Arteria brachialis wegen cystischer Adventitia-Degeneration wurde durch eine spindelförmige Wandresektion der Arterie und eine Venenpatchplastik erfolgreich behandelt.
    Notizen: Abstract Cystic degenerative disease of the brachial artery, which caused acute and total occlusion of the artery was encountered in a 51 years old male patient. At the exploration of the brachial artery at the lower border of the axialla, an anatomical variation, high division of the superficial brachial artery, was observed. At the bifurcation of the artery, a cystic degenerative change was detected and was judeged to be the cause of the arterial occlusion. He was treated successfully with partial resection of the arterial wall containing the cyst, followed by autologous vein patch plasty.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02468684
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