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  • 1
    Electronic Resource
    Electronic Resource
    Mitochondrial mutation as a probable causative factor in familial progressive tubulointerstitial nephritis (1997)
    Springer
    Human genetics 〈Berlin〉 99 (1997), S. 484-487 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Renal biopsy of two children and a maternal relative, diagnosed with severe progressive tubulointerstitial nephritis, has shown the presence of distorted mitochondria. Mitochondrial DNA from the blood of these patients was analysed. No major deletions were found, but an A to G mutation was detected in position 5656. It is proposed that this mutation might play a causative role in the renal disease of the patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050393
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microvascular injury and repair in acute human bacterial pyelonephritis (1987)
    Springer
    Virchows Archiv 411 (1987), S. 257-265 
    Details
    ISSN: 1432-2307
    Keywords: Acute pyelonephritis ; Polymorphonuclear leukocyte ; Endothelial cell ; Microvascular injury ; Microvascular repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute inflammatory cell-capillary endothelial cell interactions, related to injury and repair, were investigated light and electron microscopically in acute human bacterial pyelonephritis. In inflammatory infiltrate-adjacent microvessels, the small capillaries were completely occluded by leukocyte plugs and the large capillaries were densely filled with acute inflammatory cells adhering to the endothelium. Severe damage to small and large capillaries was observed around endothelium adherent, degranulated neutrophil granulocytes containing phagocytosed bacteria. There were spaces in the endothelium, degradation of the vascular basement membrane, of the perivascular interstitial matrix and of collagen fibrils, with fibrin deposition and vessel wall fragmentation. In the small capillaries relatively distant from the interstitial infiltrates, emigration of leukocytes was frequently seen. Around the escaping cells the endothelial lining displayed occasional discontinuities, allowing leakage of vascular fluid into the interstitial space. Some small capillaries not related to the infiltrate were occluded by fibrin thrombi with apparent damage to the endothelial cells and disruption of the capillary wall. Various reparative changes were noticed in association with this change including capillary neovascularization. The findings confirm the existence of polymorphonuclear leukocyte-mediated injury of capillaries during the development of inflammatory responses in acute pyelonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735032
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  • 3
    Electronic Resource
    Electronic Resource
    Lipoma of the liver: a differential-diagnostic problem (2000)
    Springer
    Langenbeck's archives of surgery 385 (2000), S. 31-33 
    Details
    ISSN: 1435-2451
    Keywords: Key words Colorectal malignancy ; Focal liver disease ; Liver lipoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background and aims: Lipomatous tumors of the liver are extremely rare; most of them are found incidentally at autopsy. Appropriate methods of the diagnosis of these lesions are ultrasonography (US), computed tomography (CT) and biopsy. Case report: The case of a 65-year-old man who had undergone an upper-rectum resection because of exulcerated adenocarcinoma of the rectum is described. Six months later, routine control examination revealed a solid tumor in the left lobe of the liver. The tumor was not demonstrated by either sonography or CT before the operation. Repeated US, CT scan and fine-needle biopsy could not exclude the possibility of a metastatic tumor secondary to previous malignancy. The lesion was removed by wedge resection and was proven to be a lipoma. Conclusion: Despite adequate preoperative examination (CT, biopsy and US), an anamnestic adenocarcinoma of the rectum can lead to inappropriate therapy. The inadequate result of our therapeutic policy can be explained by the extremely rare incidence of lipoma of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050007
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  • 4
    Electronic Resource
    Electronic Resource
    Renal disease in multiple myeloma (1992)
    Springer
    Geriatric nephrology and urology 2 (1992), S. 25-34 
    Details
    ISSN: 1573-7306
    Keywords: Bence Jones cast nephropathy ; diphosphate ; light chain deposition nephropathy ; multiple myeloma ; renal AL-amyloidosis ; renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Multiple myeloma is a malignant tumor of B (plasma) cells that is characterized by monoclonal immunoglobulin production. The incidence of myeloma is increasing worldwide, particularly among individuals of advanced age. Renal impairment at diagnosis is present in approximately 20% of patients with myeloma, and uremia is the cause of death in about 15%. Several renal disorders may be present in myeloma. Bence Jones cast nephropathy (BJCN), acute tubular necrosis, and “nonspecific” tubulointerstitial nephritis are related to nephrotoxic light chains in urine. Hypercalcemia potentiates the toxicity of urinary light chains. The tissue deposition of light chains leads to renal AL-amyloidosis or light chain deposition nephropathy (LCDN). In necropsy series, the incidence of BJCN, renal AL-amyloidosis, and LCDN is about 30%, 10%, and 4%, respectively. Clinically, urinary nephrotoxic light chain-associated disorders and LCDN are usually manifested in chronic or acute renal failure. The nephrotic syndrome is commonly due to renal AL-amyloidosis. Most cases of end-stage renal failure are due to BJCN and LCDN. The basic therapy of renal impairment is hydration, forced diuresis, and initiation of chemotherapy. Diphosphonates are effective new tools for the correction of hypercalcemia, and decrease the incidence of pathological fractures. In acute renal failure, plasma exchange in association with forced diuresis, dialysis, and chemotherapy may improve renal function. End-stage renal failure requires maintenance renal replacement therapy. In myeloma patients with advanced age, the limits of medical intervention should be judged individually. Particular attention should be paid to the supportive care of the patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451325
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    Paper (German National Licenses)
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