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  • 1
    Digitale Medien
    Digitale Medien
    Left ventriculotomy of the heart: tissue repair and localization of collagen types I, II, III, IV, V, VI and fibronectin (1990)
    Springer
    Virchows Archiv 417 (1990), S. 229-236 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Heart ; Wound repair ; Collagen types ; Dog
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The reparative process following left ventriculotomy was investigated immunohistochemically using anti-type I, II, III, IV, V and VI collagen antibodies, and anti-fibronectin antibody. Wound healing began with proliferation of young fibroblasts positive for type I, III and V collagens at the wound margin; vascular granulation tissue then grew into the injured myocardium followed by deposition of fibrous components immunoreactive with type I and III. At 30 days after operation when almost the entire thickness of the myocardium at the wound was replaced by fibrosing granulation tissue, a small cluster of adipocytes appeared around capillaries at the wound margin. The granulation tissue was gradually replaced by the adipose tissue with establishment of a fibrous union at the subendocardium by 90 days. In addition to type I and III collagens, type VI collagen was detected in a fine fibrillary pattern along thick collagen fibre bundles in the fibrous tissue and around the adipocytes. Fibronectin was distributed diffusely in the granulation tissue and gradually decreased with increase of the fibrous components. These results indicate that the ventriculotomy was finally repaired in the form of a fibrous scar, particularly in the endocardium. There was marked infiltration of adipose tissue in the damaged myocardium. Presumably type VI collagen, as well as type I and type III collagens, plays an important role in wound union.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600138
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  • 2
    Digitale Medien
    Digitale Medien
    Positioning for simultaneous intracardiac repair and/or ascending aorta and descending aorta surgery (1981)
    Springer
    Surgery today 11 (1981), S. 385-387 
    Details
    ISSN: 1436-2813
    Schlagwort(e): surgical positioning ; simultaneous surgery of the heart and aorta
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A convenient positioning for simultaneous intracardiac repair and/or ascending and descending aorta surgery is presented. A Rastelli operation for pseudotruncus is described step by step as an example.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02468966
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  • 3
    Digitale Medien
    Digitale Medien
    Brain damage after deep hypothermia in dogs (1982)
    Springer
    Surgery today 12 (1982), S. 61-70 
    Details
    ISSN: 1436-2813
    Schlagwort(e): brain damage ; hypothermia ; deep hypothermia ; circulatory arrest
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Histopathological and succinic acid dehydrogenase (SAD) activity changes, and the electron spin resonance (ESR) were examined in the brains of dogs exposed to various hypothermic conditions. A simple hypothermic cardiac arrest of 5 min duration occurred in the group subjected to 28°C, and normal SAD activity was noted in dogs exposed to 1-hour extracorporeal circulation under normothermia. In cases of a hypothermia below 28°C, a decrease in enzyme activity, marked histopathological changes and the disappearance of the ESR signal were observed. In dogs killed immediately after induction of 20°C hypothermia, the histopathological changes were primarily ischemic in nature, while in dogs killed at 1–12 month intervals after the experiments, irreversible gliosis was dominant. Our findings suggest that, to avoid brain damage under conditions of deep hypothermic circulatory arrest, the critical range is between 26–28°C for rectal, and approximately 28–30°C for brain temperature.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02469017
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  • 4
    Digitale Medien
    Digitale Medien
    Advantages of using the midline incision right retroperitoneal approach for abdominal aortic aneurysm repair (1996)
    Springer
    Surgery today 26 (1996), S. 1-4 
    Details
    ISSN: 1436-2813
    Schlagwort(e): midline incision ; right retroperitoneal approach ; abdominal aortic aneurysm ; wound complications
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study was conducted to compare the midline incision right retroperitoneal approach for repairing abdominal aortic aneurysms (AAA) with the transperitoneal approach. The intra- and postoperative course of 15 patients who underwent AAA repair using the transperitoneal approach between 1987 and 1991 and another 15 patients who underwent AAA repair using the retroperitoneal approach between 1991 and 1994 were evaluated. The incidence of postoperative wound complications was also assessed. There was no operative or hospital death in either group. Although a significantly longer interval was required from the incision to the aortic clamp using the extraperitoneal method, there were no statistical differences in the aortic clamping time, total operation time, or blood loss between the two groups. On the other hand, there was a statistically significant improvement in bowel function and a significant reduction in the length of postoperative hospitalization following the extraperitoneal procedure. Furthermore, no wound complications such as those associated with the left flank incision developed after the extraperitoneal procedure. Thus, we recommend the midline incision right retroperitoneal approach for AAA as it does not involve muscle division and is associated with fewer complications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00311983
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  • 5
    Digitale Medien
    Digitale Medien
    Surgical correction of pectus excavatum for adults and adolescents (1984)
    Springer
    Surgery today 14 (1984), S. 472-478 
    Details
    ISSN: 1436-2813
    Schlagwort(e): funnel chest ; strut method ; AO-plate ; funnel index ; bone-marrow scan
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract As an operative procedure for the correction of funnel chest in adult and adolescents, a strut method using AO-plates was used. All of the concaved parts of the sternum, costate, and cartilages contributing to the formation of the deformity were osteotomized to mobilize and elevate the deformed part. A vertical plate was used for fixation of the transected sternum, and three transverse plates were used as the portions which are curved appropriately to remodel the reconstructing chest wall. These plates were removed twelve to eighteen months after implantation. To date, thirty-one patients have undergone this repair. For the first eight, a single transverse plate was used, however, re-retraction of the region around the transverse plate became evident in the long term follow-up. Therefore, two or three plates were inserted for an improvement. When three transverse plates were used, retraction at the costal arch was relieved. Although a second operation is required to removal of the plates, we hold the view that this is the most effective operative procedure for the correction of funnel chest in adults and adolescents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02469789
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  • 6
    Digitale Medien
    Digitale Medien
    Bilateral sleeve lobectomy for metachronous multiple primary lung cancer (1986)
    Springer
    Surgery today 16 (1986), S. 56-61 
    Details
    ISSN: 1436-2813
    Schlagwort(e): lung cancer ; sleeve lobectomy ; metachronous multiple cancer ; high frequency ventilation ; immunochemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a patient with metachronous multiple primary lung cancer, bilateral lobectomy was performed, using bronchoplastic procedures. This case may be one of very few such cases reported in the literature. A 56-year-old man with squamous cell carcinoma was surgically treated for lung cancer. At the first operation, right upper lobectomy with wedge resection of the right main bronchus was performed, as the tumor occupied the orifice of the right main bronchus. Six months later, re-operation for stricture at the anastomotic line was done because of granulation. By means of sleeve resection of the strictured right main bronchus, the airway was reconstructed. The patient remained well for five years, then a similar cancer at the orifice of the left lower lobe and bulging into the left main bronchus became evident. Left lower sleeve lobectomy was done for the second primary cancer. The postoperative course was uneventful and he is well with no signs of recurrence 6 years and 10 months after the first operation and 19 months after the second sleeve lobectomy
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471071
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  • 7
    Digitale Medien
    Digitale Medien
    Intraoperative evaluation of coronary bypass grafts by measuring myocardial blood flow using the electrolytic hydrogen clearance method (1988)
    Springer
    Surgery today 18 (1988), S. 509-513 
    Details
    ISSN: 1436-2813
    Schlagwort(e): myocardial blood flow ; coronary bypass surgery ; hydrogen clearance method
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The regional myocardial blood flow (MBF) was measured in 33 patients who underwent coronary bypass graft surgery in order to evaluate the efficiency of coronary bypass grafts in restoring MBF. MBF was measured by the electrolytic hydrogen clearance method during the coronary bypass surgery. The mean prebypass MBF was 161±19, 162±12, 80±12, 43±14, 104±18 ml/min/100 g in segments supplied by the left anterior descending coronary artery (LAD) showing ≦50 per cent, 75 per cent, 90 per cent, 99 per cent, and 100 per cent stenosis with collaterals, respectively. After bypass grafting of the LAD, the mean MBF increased from 70±13 and 126±12 ml/min/100 g to 133±14 and 163±9 ml/min/100 g in the segments with and without infarction, respectively. The mean postbypass MBF was 149±10 and 152±14 ml/min/100 g in the segments supplied by the LAD bypassed with saphenous vein grafts and mammary artery grafts, respectively. Postbypass MBF was dependent upon the magnitude of myocardial infarction. Measurement of MBF by the electrolytic hydrogen clearance method made it possible to quantitatively evaluate myocardial perfusion at the time of operation. It also provided direct information about the effectiveness of myocardial revascularization.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471483
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  • 8
    Digitale Medien
    Digitale Medien
    The histological effects of cryocoagulation on the myocardium and coronary arteries (1989)
    Springer
    Surgery today 19 (1989), S. 319-325 
    Details
    ISSN: 1436-2813
    Schlagwort(e): cryocoagulation ; epicardial cryolesion ; endocardial cryolesion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of epicardial and endocardial cryolesions were histologically studied in 29 dogs. To produce epicardial lesions, hypothermic exposure was applied at −60°C for 3 minutes, over or adjacent to the left anterior descending coronary artery. To produce endocardial lesions, exposure was applied at −60°C for 2 minutes, using the inflow occlusion technique over the ventricular septum. The dogs were killed 30 minutes to 6 months later. The cryolesions were sharply demarcated from the surrounding tissues and showed similar healing processes. The lesions showed no tendency to form aneurysms or rupture, although moderate intimal thickening of the coronary artery subjacent to the probe was observed. Our results indicate that cryocoagulation may greatly contribute to the surgical treatment of cardiac arrhythmias.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471408
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  • 9
    Digitale Medien
    Digitale Medien
    Changes in immunological parameters in lung cancer patients undergoing immunotherapy with streptococcal preparation OK-432 (1990)
    Springer
    Biotherapy 2 (1990), S. 235-245 
    Details
    ISSN: 1573-8280
    Schlagwort(e): immunotherapy ; lung cancer ; OK-432 ; streptococcal preparation ; immunological parameter ; SU-polysaccharide skin test
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have studied the immunological status of patients treated with streptococcal preparation OK-432. Two KE of OK-432 was injected intramuscularly once every week for more than three years unless the patients died. The natural killer (NK) activity in those patients who underwent curative surgery for lung cancer and had no sign of recurrence was significantly increased (P 〈 0.01) during the OK-432 treatment. However, the NK activity in the patients who had persistent disease (non-resected cases, incompletely resected cases or recurrent cases) was not significantly increased in comparison with that before the immunotherapy. Also, in the cases with no clinical symptoms of recurrence, both the lymphoblastogenetic reactions to the mitogens and the IL-2 production were significantly enhanced(P 〈 0.01) during the administration of OK-432. Reactions in the SU-PS (polysaccharide taken from the cell-wall fraction of theStreptococcus pyogenes SU strain and containing 7.2% of protein) skin-test appeared to significantly correlate with the immunological status of the patients under OK-432 therapy, but the PHA and PPD skin reactions showed no definitive enhancement. The survival rate of the patients whose SU-PS skin tests were positive during the OK-432 immunotherapy was significantly higher (P 〈 0.01) than that of the patients with negative reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02173525
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  • 10
    Digitale Medien
    Digitale Medien
    Surgical procedure for right anteroseptal accessory conduction pathways in Wolff-Parkinson-White syndrome (1998)
    Springer
    The international journal of angiology 7 (1998), S. 286-288 
    Details
    ISSN: 1615-5939
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In patients with Wolff-Parkinson-White syndrome, the right anteroseptal accessory conduction pathway is rare, and exists from the atrium to the ventricle in close anatomic proximity to the normal atrioventricular conduction system. Catheter ablation of this lesion is reported to interrupt atrioventricular node-His bundle conduction more easily than that of other lesions. At our institute, there were 10 patients with right anteroseptal accessory conduction pathway among 454 patients (2.2%) who underwent the surgical division of the accessory pathway. Our procedure involved the the endocardial approach with knife dissection and cryocoagulation. With the heart beating under normothermal cardiopulmonary bypass, delta wave disappearance was easily noted. Neither complete atrioventricular block nor recurrent conduction occurred. Cryoablation used by our endocardial surgical division, is a safe and accurate procedure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01623869
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