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  • 1
    ISSN: 0009-8981
    Keywords: Adrenoleukodystrophy ; Erythrocyte membrane ; Fatty acid ; High-performance liquid chromatography
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 342 (1985), S. 359-362 
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Optics Communications 97 (1993), S. 74-78 
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-1463
    Keywords: Sulfamethoxazole-trimethoprim ; Machado-Joseph disease ; dihydrofolate reductase ; dihydropteridine reductase ; tetrahydrobiopterin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed a double-blind, placebo-controlled, crossover trial of sulfamethoxazole-trimethoprim (S-T) in 8 patients with Machado-Joseph disease (MJD), and measured the blood and cerebrospinal fluid levels of biopterins, biogenic amines or metabolites, and folate. The clinical results were as follows; mild improvements of hyperreflexia of knee jerks and of rigospasticity of the legs during S-T treatment period. In addition, S-T significantly reduced the times of 8 motor activities on the timed tests. The biochemical results showed that basal levels of all biopterins and homovanillic acid in the cerebrospinal fluid (CSF) were reduced to less than half the levels of those of controls with other neurological diseases. After S-T treatment, total and oxidized form of biopterins in the CSF increased significantly. Therefore, S-T may be effective to neurologic deficits through its mechanism of increasing the level of brain biopterins.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Cerebrospinalis fluid ; Light chains of type kappa ; Radial immunodiffusion ; Double ring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der radialen Immunodiffusion des Liquors wurden Doppelringe bei Bestimmung der leichten Ketten vom Typ Kappa, nicht jedoch vom Typ Lambda beobachtet. Die Doppelringe traten auf bei 24 von 42 Patienten mit multipler Sklerose, 1 Patienten mit cerebraler Cysticercose, 1 von 3 Patienten mit Neurosyphilis und 1 Patienten mit ungeklärter Paraspastik der Beine. Im Liquor von 73 Patienten mit anderen Erkrankungen des Nervensystems wurde der Doppelring nicht gesehen. Alle Liquors mit Doppelring zeigten einen tiefen Linksausfall der Mastix-Kurve. Mit Ausnahme eines Liquors bei multipler Sklerose hatten alle erhöhte Immunoglobulin G-Konzentrationen und erhöhte Immunoglobulin G-Quotienten. Die Untersuchung ist leicht durchführbar, man benötigt nur 6 μl uneinengten Liquors. Die Untersuchung könnte die Diagnose „multiple Sklerose“ sichern helfen.
    Notes: Summary Double ring formation in single radial immunodiffusion for light chains of type kappa and not for light chains of type lambda was observed in cerebrospinal fluid in 24 out of 42 patients with multiple sclerosis, 1 patient with cerebral cysticercosis, 1 of 3 patients with neurosyphilis and 1 patient with spastic paraparesis of unknown eitology. Double ring formation was not observed in cerebrospinal fluid of 73 patients with other various diseases of the nervous system. All patients with double ring formation showed deep Mastix curves of the left type. All of them except one with multiple sclerosis showed increased immunoglobulin G values and increased immunoglobulin G ratios. The test is simple and requires only 6 μl of unconcentrated cerebrospinal fluid. In the analysis of cerebrospinal fluid immunoglobulins it could be applied as a further diagnostic aid in establishing a diagnosis of multiple sclerosis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 208 (1974), S. 17-25 
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Retrobulbar neuritis ; Optic nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 34 von 69 japanischen Patienten mit wahrscheinlicher multipler Sklerose (MS) zeigten Sehstörungen beim ersten Krankheitsschub. Bei 16 dieser 34 Patienten waren die Opticus-Symptome das einzige Symptom. Diese Fälle wurden als retrobulbäre Neuritis (RBN) diagnostiziert. Die klinischen Bilder dieser 16 Patienten wurden geschildert und analysiert. In dieser Serie überwogen weibliche Patienten im Verhältnis 4,3:1. Das Durchschnittsalter betrug bei Krankheitsbeginn 27 Jahre. Das Intervall zwischen dem Ende der ersten RBN zum nächsten Schub reichte von 1 Monat bis zu 13 Jahren. Seite und Art der Erkrankung, Schwere und Dauer der ersten Sehstörungen oder Grad der Besserung scheinen die folgende Entwicklung der anderen klinischen Symptome von MS nicht zu beeinflussen. Es ist bemerkenswert, daß 11 dieser 16 Patienten eine Sehstörung auch während des zweiten Schubes zeigten. Ein Vergleich der MS-Patienten, die eine Sehstörung als einziges Initialsymptom aufweisen, zwischen den östlichen und westlichen Ländern wäre in Zukunft wünschenswert.
    Notes: Summary Of 69 consecutive Japanese patients with probable multiple sclerosis (MS), 34 patients showed visual impairment at the initial bout. 16 out of these 34 patients manifested only the optic symptoms at the onset, without other clinical evidence of MS, and the condition was diagnosed as retrobulbar neuritis (RBN) initially. The clinical pictures of these 16 patients are described and analyzed. This series showed a female preference with the male-to-female ratio of 1 to 4.3. The age at onset was 27 years on the average, which is not significantly different from that of the whole MS series (31 years). The interval from the end of the initial RBN to the second bout ranged from 1 month to 13 years, but was less than 4 years in all cases but 2. The laterality, mode of onset, severity and duration of the initial visual impairment, or the degree of recovery from the initial bout did not seem to influence the subsequent occurrence of other clinical evidences of MS. It is noteworthy that in 11 out of the 16 patients the symptom at the second bout was, or at least also included, visual impairment. Comparison of MS patients, who started with visual impairment as the sole initial symptom, between the Oriental and Western countries is warranted.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of infrared and millimeter waves 8 (1987), S. 1-11 
    ISSN: 1572-9559
    Keywords: millimeter wave receiver ; SIS junctions ; mixer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A 40 GHz band SIS mixer receiver has been built using Nb/Al−AlOx/Nb array junctions and a 4.3 K closed cycle helium refrigerator. The minimum conversion loss of the mixer is 2±1 dB and the single sideband receiver noise temperature (TRX (SSB)) is as low as 110±10 K at 36 GHz. TRX (SSB) is almost constant in the IF bandwidth of 600 MHz. The mixer saturation level is as high as 15 nW, which is comparable to the injected LO power.
    Type of Medium: Electronic Resource
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