ISSN:
1432-2277
Keywords:
Liver preservation, rat, UW solution
;
Rat, liver preservation, UW solution
;
U74500A, rat liver preservation
;
Lidoflazine, rat liver preservation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of hepatocellular enzymes (ASAT, ALAT, and LDH) into the perfusate was determined with increasing time. Both drugs reduced the amount of enzymes lost from the liver. The combination of the two drugs was better than either drug alone. These data suggest that both agents may be of value in organ preservation for clinical liver transplantation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00336028
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