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  • 1
    Electronic Resource
    Electronic Resource
    A biological model of the excitation of a second order sensory neurone (1969)
    Springer
    Biological cybernetics 6 (1969), S. 141-145 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Summary Computer simulation of a relatively simple model can reproduce the main characteristics of the firing patters of some nerve cells. The abdominal stretch receptor of the crayfish has provided an analogous biological model. Synaptic input impulses were simulated by randomly distributed, short lasting transmembrane current pulses. Under these experimental conditions the stretch receptor neurone largely behaved as predicted by the computer simulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274107
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A computer simulated model of a second order sensory neurone (1969)
    Springer
    Biological cybernetics 6 (1969), S. 130-141 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Summary The behaviour of neurones during signal transmission is determined partly by the input to the nerve cell and partly by its inherent properties. A detailed knowledge of the spike trains, which are input to and output from a synapse, may yield information about these synaptic mechanisms. This problem has been treated in relation to data from the dorsal spino-cerebellar tract (DSCT) cells monosynaptically activated from primary endings of muscle spindles. After a description of the firing pattern of these cells the behaviour of various models are examined by computer simulation. A particular type of model approximates the behaviour of the DSCT neurones closely with a rather narrow set of parameters. The model predicts that about 15 primary afferent fibres from one muscle converge on one DSCT cell and that the average size of their EPSPs may be as large as 50% of the threshold of firing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274106
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Maintained Function of Foreign Synapses on Hyperinnervated Skeletal Muscle Fibres of the Rat (1974)
    [s.l.] : Nature Publishing Group
    Nature 247 (1974), S. 375-376 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The superficial fibular nerve, which normally innervates flexor muscles in the lower leg, was used as the foreign nerve in our experiments. It was dissected, cut peripherally, and transplanted into the proximal surface of the soleus muscle of young rats. Two weeks later the soleus was deprived of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/247375a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The innervation of skeletal muscles in chickens curarized during early development (1983)
    Springer
    Journal of neurocytology 12 (1983), S. 887-919 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chicken embryos were treated with partially paralysing doses ofd-tubocurarine (dtc) from embryonic (E) days 6 to 10. The pattern of innervation of the lateral gastrocnemius (GL) muscle was examined both morphologically and physiologically just before hatching on day E20 or E21. There was a 70% increase in number of surviving motor neurons in the lateral motor column and a 50% increase in the number of myelinated axons in the nerve to GL. The GL muscle was significantly atrophic, with an average weight of 40% of normal. The atrophy was largely due to the reduced size of the muscle fibres. The mean size of the motor units was essentially unchanged or perhaps slightly increased. There was a striking increase in the level of polyneuronal innervation of the muscle fibres, both in terms of number of synaptic sites per fibre and number of axons innervating each site. Spontaneous miniature endplate potentials (mepps) indicated focal innervation of the fibres in the normal muscle. Most fibres in the dtc-treated muscles had mepps of widely varying time courses, and there was no simple relation between amplitude and rise time. Many of the slow mepps were not represented in the endplate potentials evoked by nerve stimulation. The quantal content of the endplate potential (epp) was generally increased in the dtc-treated muscles. The findings are discussed in terms of a retrograde signal from muscle to nerve and its dependence on muscle activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01153341
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Morphological aspects of the elimination of polyneuronal innervation of skeletal muscle fibres in newborn rats (1976)
    Springer
    Journal of neurocytology 5 (1976), S. 591-604 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of neuromuscular junctions of rat soleus muscles 1–40 days postnatally was examined for possible morphological correlates of the transient polyneuronal innervation which is present in newborn rats. Several vesicle-laden profiles of terminal axons are seen to contact each muscle fibre up to 8 days postnatally. Axon terminals often lie close together, without Schwann cell intervention. Between days 8 and 16 the number of profiles of terminals on each muscle fibre is reduced, and both Schwann cells and ridge-like extensions of muscle fibre cytoplasm intervene between and separate axon terminals. No signs of degenerating intramuscular axons or axon terminals could be found. It is suggested that the redundant terminals are eliminated by retraction into the parent axons. This process is apparently accomplished without any morphological signs of degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01175572
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    Paper (German National Licenses)
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