ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
We have examined if the age-related susceptibility of DBA/2J mice to audiogenic seizures is the result of an abnormality in the number or sensitivity of brain adrenoceptors. The binding of α1--, α2--, and β-adrenoceptor ligands to membranes prepared from whole brain or regions of brain of DBA/2J mice was measured at various ages, corresponding to the periods before, during, and after the maximal sensitivity to audiogenic seizures. For comparison, we have studied concurrently age-matched C57 B1/6 mice, a strain resistant to audiogenic seizures at all ages. There was no difference in the binding of α2-- or β-adrenoceptor ligands to whole brain membranes between the two strains of mice at any age. The maximal number of α1--adrenoceptor binding sites was lower in whole brains of DBA/2J mice than of C57 B1/6 mice at all ages studied except 13–15 days of age. The differences were small (maximally 17%) but were statistically significant at 21–23 days of age, the time of maximal sensitivity of DBA/2J mice to audiogenic seizures. No difference between the two strains was found in the number or affinity of α1-- or α2--adrenoceptor binding sites at any age in any of the brain regions studied. The age-related susceptibility of DBA/2J mice to audiogenic seizures is not the result of an abnormality in number or sensitivity of α2-- or β-adrenoceptor binding sites, but a reduced number of α1--adrenoceptor binding sites may be involved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1986.tb02846.x
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