Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
14 (1987), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
SUMMARY1. The post-receptor mechanisms of α1 and α2-adrenoceptor subtypes in guinea-pig aorta and human digital arteries have been explored.2. Nifedipine antagonized contractile responses of human digital arteries to TL99 and methoxamine to a similar degree, thus suggesting that neither the α1 nor the α2 receptor is preferentially linked to calcium entry through voltage-operated channels of the cell membrane.3. In the guinea-pig aorta, which contains only α1-adrenoceptors, methoxamine-stimulated inositol phosphate (IP) production at similar concentrations was required to produce contractile responses.4. In the human digital artery, noradrenaline also produced a significant increase in IP formation, but preliminary experiments have suggested that both TL99 and methoxamine stimulate IP production.5. Thus, the present authors have been unable as yet to confirm, in a tissue which contains both α1-and α2-adrenoceptors, that the post-receptor mechanisms of the α subtypes are different.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1987.tb00987.x
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