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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Insectes sociaux 3 (1956), S. 17-24 
    ISSN: 1420-9098
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Durch Implantation vonCorpora allata war es möglich, die Entwicklung vonLocusta migratoria im Herdenzustand trotz großer Aufzuchtdichte so zu stören, daß Individuen mit verschiedenen Merkmanlen solitärer Formen entstanden. Um diese gestörten Typen besser klassifizieren zu können, wurden genauge Untersuchungen über das Wachstum derjenigen Organe durchgeführt, die für das Studium der Herdenbildung herangezogen werden. Die Untersuchungen wurden mit den üblichen Methoden durchgeführt. Nähere Angaben siehe Résumé (französische Fassung), mit Skizze. Schlußlogerungen: 1) Die Metamorphose vonL. migratoria wird nich erst mit der letzten Häutung für alle Organe gleichzeitig beendent. Bei den Flügeln geschieht dies bei der 3., 4. und 5. Häutugn, für den Kopf bei der 5., für den Thorax beim 3. und 5. Häutungsschritt. 2) Die solitären Formen sind in ihren biometrischen Indices ein wenig larvenähnlicher als die herdenbildenbildenden Tiere. Wenn man die Metamorphose herdenbildender Tiere stört, kann man Tiere mit den Indices solitärer oder sogar hypersoltärer Heuschrecken erzielen. Das bedeutet für die Praxis, daß die klassischen Indices, wie sie zur Beurteilung der Herdenbildungstendenz (grégariosité) einer Population von Acridiern herangezogen werden, äußerst stark durch metamorphosehemmende Faktoren beeinträchtigt werden können. 3) Die solitären Tiere sind gleichartig durch ihre Pigmentierung und die Form ihres Pronotalkiels charakterisiert. Auch die Pigmentierung ist empfindilich gegenC. allata, wenn auch die Beziehungen nicht so einfach erscheinen wie bei der Metamorphose. Der Kiel (carena) wird nicht durch dieses Organ beeinflußt. Dies alles führt zu der Vermutung, daß die Herdenphase eine Hypofunktion derC. allata darstellt und daß diese mehr oder minder für die Ausgestaltung der morphlogischen Merkmale verantworltich sind.
    Notes: Summary By implantations ofCorpora allata it was possible to disturb the development of the swarming type ofLocusta migratoria, maintained in dense breeding groups, to such an extent that we were able to obtain individuals which in diverse features were very similar to the solitary types. In order to appreciate the exact signifcane of this “disturbed” type, closer examinations were made of the growth of those organs, from which at the present the classical measurements are taken for the study of swarm-formation. These examinations were carried out in the usual ways. For furthe details, see the French version of the résumé and sketch. Conclusions: 1. The metamorphosis ofL. migratoria does not take place at the same time as the last casting of the skin, and is not simulatneous for all organs. For the wings it takes place during the 3rd, 4th and 5th moultings, for the head during the 5th, and for the thorax during the 3rd and 5th moultings. 2. In its biometrical indices the solitary type resembles the larvae more than does the swarming type. By disturbing the metamorphosis of gregarious locusts, it is possible to obtain insects with the indices of the solitary type or even the hypersolitary type. From a practical point of view, this means that the indices used in the clalssical manner to appreciate the gregariousness of an “acridien” population are very sensitive to factors which disturb the metamorphosis. 3. The solitary types are characterised equally by their pigmentation and by the form of the pronotal carena. The pigmentation is also sensitve to the action ofC. allta, but in a less simple manner than the metamorphosis. The carena does not seem to be influenced by this organ. These facts lead us to the assumption that the gregarious phase introduces a hypo-activation of theC. allata, which is more or less responsible for the development of the morphological factors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Numerische Mathematik 54 (1989), S. 655-702 
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65N05 ; CR: G1.8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary In this paper, we analyze the approximation of acoustic waves in a two layered media by a finite diffrences variational scheme. We examine in particular the approximation of the guided waves. We point out the existence of purely numerical parasitic phenomena and quantify the numerical dispersion relative to guided waves.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 4 (1995), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Recent studies have shown that interleukin–2 (IL2) is less toxic when administered subcutaneously than intravenously. Moreover interferon α and Dacarbazine could increase the efficiency of IL2.Patients and methods Nineteen ambulatory patients with metastatic melanoma (1 stage 111 and 18 stage IV) were treated with an association of dacarbazine 400 mg/m2, interferon α2a (Roferon) 9 × l06 IU 3 times per week administered subcutaneously and recombinant interleukin-2 (IL–2) (Eurocetus) 3 × 106 IU five days per week for two weeks per month subcutaneously. The treatment consisted of 2 induction cures separated by a one-month interval followed by evaluation studies.Results At the end of the induction phase. 2 complete and 3 partial responses (response rate 26.2%) were observed. These responses were obtained in patients with sinus (1 case), skin (3 cases), lymph node (2 cases), bone (1 case) and liver (I case) targets. The mean response period was 10 months for the 2 complete responses. No patients had grade 4 toxicity, and treatment was stopped for only one patient. Painful subcutaneous nodules frequently (23%) formed at the injection site.Conclusion The association of subcutaneously administered dacarbazine, interferon α and IL2 would thus seem of interest for the treatment of metastatic melanoma. Moreover, toxicity is tolerable and compatible with ambulatory treatment ensuring the patient a decent quality of life.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0009-8981
    Keywords: Angina pectoris ; B lipoprotein particle ; Impaired fibrinolysis ; Lp(a) ; Myocardial infarction ; PAI-1 ; Plasminogen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Behavioural Processes 19 (1989), S. 47-56 
    ISSN: 0376-6357
    Keywords: breeding site ; homing ; metapopulation ; newt ; philopatry ; site fidelity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fifty patients allergic to mite were tested for D. pteronyssinus using two prick-test techniques; the classical method by Pepys and the Morrow-Brown needle. Each patient received six tests with each method on the two forearms. The evaluation of the weal areas was conducted in two ways: by weighing the shapes of the tests transferred on to paper, and by measuring the two greatest diameter lengths. No significant difference was observed between the two methods. No significant difference was observed between the measurements of the same tests carried out at 2-monthly intervals by the same examiner.With the Pepys method the weal area sizes are significantly larger than with the Morrow-Brown needle, and the variance is much greater with the Pepys technique. However, the coefficients of variation are similar and in both cases the techniques are equally reproducible. No significant difference was found in the weal sizes with regard to the injection sites on the forearm with either of the two methods. The correlation between the weal area sizes and the log of the IgE levels is closer with the Morrow-Brown needle.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report changes in the antigen recognition pattern of sera from two pemphigus foliaceus patients with a long-term follow-up. The patients' sera were analysed by immunoblotting using different antigenic sources: cultured human keratinocytes, bovine tongue epithelium and a recombinant protein corresponding to the C-terminal end of the 230-kDa bullous pemphigoid antigen. While initial serum samples reacted exclusively with the 160-kDa desmoglein 1, the later sera reacted both with desmoglein 1 and a 190-kDa antigen immunolocalized to the desmosomal plaque, previously demonstrated to be recognized by sera of some patients with paraneoplastic pemphigus. lgG subclass analysis further showed that antidesmoglein 1 antibodies were of lgGl and/or IgG4 subclasses, while anti-190-kDa antibodies were lgG3. The patients were free of malignancy.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a patient with erythema gyratum repens (EGR), in whom a bronchial carcinoma was found. Direct immunofluorescence revealed granular deposits of immunoglobulins at the basement membrane zone (BMZ) in the skin, and in the lung tumour. Direct immunoelectron microscopy showed that the immune deposits were localized just beneath the lamina densa. Indirect immuno- fluorescence revealed circulating anti-BMZ antibodies. Immunohistochemical staining, using anti- transforming growth factor-β, anti-epidermal growth factor receptor, antivimentin and anti-α-actin, was found to be more intense in the lesional skin and the lung tumour than in normal tissues. Possible mechanisms in the pathogenesis of EGR are discussed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report a case of herpetiform pemphigus induced by thiopronine. Direct immunoelectron microscopy performed on peribullous skin showed IgG deposits predominantly located in the extracellular portion of desmosomes. By immunoblot analysis using bovine tongue extracts as the antigen, the patient's serum recognized a 160-kDa polypeptide which comigrated with desmoglein I. This study underlines the contribution of immunoblot analysis to the diagnosis of atypical cases of pemphigus, and confirms that herpetiform pemphigus may be a clinical variant of pemphigus foliaceus.
    Type of Medium: Electronic Resource
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