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  • 1
    Electronic Resource
    Electronic Resource
    Brain activity related to serial cognitive performance resembles circuitry of higher order motor control (1996)
    Springer
    Experimental brain research 109 (1996), S. 136-140 
    Details
    ISSN: 1432-1106
    Keywords: Cognitive performance ; Positron emission tomography ; Supplementary motor area ; Parietal cortex ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Differences between two states of cerebral activation were studied in eight subjects by positron emission tomography (PET) of regional cerebral blood flow (rCBF) and subsequent statistical parameter mapping. Subjects had to respond to a row of numbers presented on tape. In one condition they had to repeat each number. In the other condition the last heard number had to be added to the number presented before. Cerebral activity specifically related to the serial addition task was distributed over supplementary motor area (SMA), left premotor cortex and superior dorsal parietal cortex bilaterally, without significant involvement of prefrontal cortex. This indicated circuitry related to mental performance characterised by a fixed strategy of executing serial manipulation of numbers within “internal space”. The main aim of this communication is to discuss the similarity between circuitry underlying higher order motor control and pure cognitive performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228634
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats (1988)
    Springer
    Experimental brain research 72 (1988), S. 439-442 
    Details
    ISSN: 1432-1106
    Keywords: Epilepsy ; Calcium antagonists ; Verapamil ; Flunarizine ; Neocortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of the organic calcium antagonists verapamil and flunarizine on pentylenetetrazol induced paroxysmal depolarizations were tested in organotypic neocortical explants taken from neonatal rats. In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases. The piperazine derivative flunarizine, however, which is known to suppress epileptic discharges in hippocampal CA3 neurons (Bingmann and Speckmann 1986), showed no significant antiepileptic effects in the explanted neocortical neurons. Thus, the present findings may indicate that the suppressive action of flunarizine on the generation of paroxysmal depolarizations is restricted to distinct populations of neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250266
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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