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  • 1
    Electronic Resource
    Electronic Resource
    Demonstration of calcitonin and carcinoembryonic antigen (CEA) in medullary carcinoma of the thyroid (MCT) by immunoperoxidase technique (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 3 (1979), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The presence of calcitonin and of carcinoembryonic antigen (CEA) was studied in six cases of medullary carcinoma of the thyroid using an immunoperoxidase technique. In five cases the material was obtained surgically and in one at autopsy. Tissue from primary tumours as well as from metastases was studied. Calcitonin and CEA were identified within all the tumours studied, although their pattern of distribution and staining intensity varied both within the cells and within the tumour. Some parts of the tumour contained both CEA and calcitonin, while others stained positively only for one of these substances. In some parts of the tumour there was no positive staining for either substance. Within the cells, CEA showed a typical linear distribution along cell surfaces, while calcitonin showed a more even cytoplasmic distribution and the deposits were more granular. Normal tissue surrounding tumour deposits did not show positive staining. It is considered that cells of medullary carcinoma of the thyroid contain both calcitonin and CEA. Identification of CEA and calcitonin in tumour tissue can be used as a diagnostic aid to identify medullary carcinoma of the thyroid. It is considered that these substances are being produced by this tumour and can be used as tumour markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1979.tb03031.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cervical cytology and chlamydia trachomatis infection (1983)
    Springer
    Archives of gynecology and obstetrics 233 (1983), S. 131-140 
    Details
    ISSN: 1432-0711
    Keywords: Chlamydia trachomatis ; CIN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We found, as have others, a strong correlation between indirect immunofluorescence techniques and cell culture for the diagnosis ofChlamydia trachomatis infection in material obtained from the cervix. Five epithelial cell types indicative ofChlamydia trachomatis infection (indicator cells) were found in smears in patients with positive immunofluorescence. An attempt to diagnoseChlamydia trachomatis infection in 50 routine smears based on the presence of these indicator cells showed false positives and false negatives so that the diagnosis ofChlamydia trachomatis still requires confirmation by immunofluorescence or culture techniques. The indicator cells frequently had the same morphometric features as cells seen with cervical intraepithelial neoplasia, which may explain why some smears revert to normal after patients are given antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114789
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    Paper (German National Licenses)
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