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  • 1
    Electronic Resource
    Electronic Resource
    Time-course of corticosteroid-induced blood flow reduction in normal cutaneous tissue—quantitative measurements during 72 h of treatment (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In eight healthy individuals, the skin fold between the thumb and the forefinger was treated with 0·05% clobetasol propionate ointment under a hydrocolloid occlusive dressing. Using the atraumatic epieutaneous 133Xe wash-out technique on the outer 2 mm of the skin fold, covering the rest of the hand with a lead shield, we were able to monitor cutaneous blood flow. Blood flow was measured after 0, 10, 24, 48 and 72 h of treatment. During the first 10 h of treatment no significant change in blood flow was observed. However, compared to untreated tissue, cutaneous blood flow decreased significantly after a 24-h period (P 〈 0·05). Furthermore a significant blood flow reduction from 0–48 (P 〈 0·02) and from 0–72 h (P 〈 0·01) was observed. Placebo did not decrease cutaneous blood flow, but a minor increase was demonstrated. The results of the present work demonstrate a long-lasting blood flow reducing effect of topical corticosteroid in normal human cutaneous tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb00934.x
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  • 2
    Electronic Resource
    Electronic Resource
    In reply (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 15 (1990), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1990.tb02129.x
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  • 3
    Electronic Resource
    Electronic Resource
    Antipsoriatic effect of local corticosteroids—O2-consumption and blood flow measurements compared to clinical parameters (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten patients with chronic plaque-type psoriasis were treated topically with the group IV corticosteroid clobetasol propionate cream (Dermovate) with and without occlusion with a semipermeable hydrocolloid dressing (Comfeel Coloplast, Denmark). The effect of treatment was compared with untreated skin and evaluated in terms of (a) O2-consumption as measured by the TCM-2-oxygen monitor from Radiometer, Denmark, (b) blood flow as measured by a laser-Doppler flowmeter (Perimed, Sweden), (c) temperature measurements using thermocouples and (d) a clinical score. While steroid +occlusion had a very pronounced effect measured by all parameters and apparent after 24 h, the steroid alone was only marginally effective after 7 days. No placebo effect was detectable in untreated skin with the laboratory methods used. It is suggested that the methods described can be used to evaluate other treatment schedules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb00911.x
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  • 4
    Electronic Resource
    Electronic Resource
    Antipsoriatic effect of semi-occlusive treatment–O2-consumption, blood flow and temperature measurements compared to clinical parameters (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten patients with plaque-type psoriasis were treated by applying semi-permeable hydrocolloid dressings (Comfeel®, Coloplast, Denmark) and the effect compared to untreated skin. The treatment effect was evaluated by: (a) O2-consumption as measured by a TCM-2 oxygen-monitor; (b) blood flow as measured by laser-Doppler flowmetry; (c) temperature measurements using thermocouples; (d) a clinical score. The treatment effect was evaluated after 1, 2 and 7 days and although there was a significant and sustained improvement in the clinical score following Day 7 (P 〉 0·05), this was not associated with a significant change in any of the objective measurements during the study (P 〉 0·05). In the same patients the clinical effect of occlusion was evaluated after 21 days in another area. A pronounced effect was observed comparable to, equal to, or better than that of crude coal tar given as daily applications followed by bathing. There was no significant change in any of the parameters at the sites of untreated psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb01981.x
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  • 5
    Electronic Resource
    Electronic Resource
    Colour changes during ‘Raynaud's phenomenon’ and finger blood supply during direct and indirect cooling procedures (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 12 (1987), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence of body (indirect cooling) and local linger cooling on finger blood pressure and blood flow was examined in 48 patients claiming Raynaud's phenomenon. Twenty-four were suffering from generalized scleroderma (GS) and 24 from Raynaud's disease (RD).Skin blood flow was measured by laser Doppler flowmetry and blood pressure measurement at different temperatures was performed by a ‘digit-cooling’ system, Colour changes during Raynaud arracks, as described b the patients, were noted. The patients could be divided into three groups: (1) Mild cases where combined finger and body cooling was needed to elicit flow arrest (Raynaud attack), or flow arrest could not be elicited in the laboratory (79% of RD and 33% of GS). Flow stop in these cases seemed to occur distally to the digital arteries. This finding was highly correlated to attacks described as pallor followed by varying degrees of rubor. (2) More severe cases, where flow arrest could be elicited after local finger cooling alone (50% of the GS and 19% of the RD patients). Here, flow stop seemed to occur at the level of the digital arteries. This finding was highly correlated to attacks described as pallor followed by cyanosis, and rubor in varying degrees. (3) The most severe cases where finger circulation stopped after body cooling (indirect cooling) alone. This was seen in 25% of GS patients. The finding was correlated with attacks described as finger cyanosis as an isolated finding, which was only seen in GS. Therefore, observing any form of finger cyanosis during Raynaud's attacks in patients should lead one to suspect an underlying disease, which may often be a connective tissue disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1987.tb02504.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Identification of ultrasonic scanning pictures of the abdomen
    Amsterdam : Elsevier
    Ultrasonics 9 (1971), S. 49-53 
    Details
    ISSN: 0041-624X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0041-624X(71)90489-6
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrasound as a guide in percutaneous puncture technique
    Amsterdam : Elsevier
    Ultrasonics 10 (1972), S. 83-86 
    Details
    ISSN: 0041-624X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0041-624X(72)90252-1
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of synthetic leukotriene D-4 on the local regulation of blood flow in human subcutaneous tissue
    Amsterdam : Elsevier
    Prostaglandins 29 (1985), S. 155-159 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(85)90198-4
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  • 9
    Electronic Resource
    Electronic Resource
    Leukotriene B"4 produces hyperalgesia in humans
    Amsterdam : Elsevier
    Prostaglandins 30 (1985), S. 791-797 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(85)90007-3
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  • 10
    Electronic Resource
    Electronic Resource
    Diurnal variations in lower leg subcutaneous blood flow rate in patients with chronic venous leg ulcers (1991)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 125 (1991), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The blood flow rate in subcutaneous adipose tissue was measured on the lower legs of 11 patients with chronic lower-leg venous insufficiency and ulceration and in eight age-matched control subjects for 12–20 h, under ambulatory conditions, using the 133Xe wash-out technique with portable Cadmium telluride (CdTe(Cl)) detectors. In both groups, the change from an upright to a supine position at the beginning of the night period elicited an instantaneous increment in the blood flow rate of 30–40% with a decrease in the central and local postural sympathetic vasoconstrictor activity. After approximately 1 h of sleep, a considerable increase in blood flow rate was seen in both patient and control groups which persisted for nearly 100 min. In the patient group, the mean increase was 137% compared to a mean increase of 68% in the control group (P〈0·01). The blood flow then returned to the same level as at the beginning of the night and remained stable until the subjects woke in the morning. The differences between this nocturnal hyperaemic phase and the adjacent phases were highly significant in both groups (P 〈0·0001 and P 〈 0·005, respectively). The blood flow levels measured on the second day were of the same magnitude as those registered on the first day. The mean values of the wash-out rate constants (k) of the two groups were of the same magnitude in all phases of subcutaneous blood flow level, except in the hyperaemic phase, where it was significantly higher in the patient group (P〈0·01).The pattern of the nocturnal blood flow rate corresponded to that described previously in a younger healthy population, but with quantitative differences, which suggests that the abnormality occurs in the neural, humoral or metabolic factors involved in the nocturnal hyperaemic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1991.tb14768.x
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