ISSN:
1432-0428
Keywords:
Pertussis vaccine
;
islet activating protein
;
insulin
;
glucagon
;
perfused pancreas
;
spontaneous diabetic rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The early phase of insulin secretion to an oral glucose load was blunted in spontaneous diabetic rats. The blunted insulin secretion was associated with markedly impaired glucose tolerance. A single injection of the islet activating protein (IAP), a protein derived from the culture medium of Bordetella pertussis, into the spontaneous diabetic rats normalised glucose tolerance. The increase in insulin response to glucose was an important contributing factor to the improvement of glucose tolerance. This curative effect of the IAP on the diabetic state was of long duration; glucose tolerance remained virtually normal over a period of one month in the diabetic rats. Perfusion of the isolated pancreas of the diabetic rats pretreated with IAP showed an increase in insulin response to glucose and loss of suppression of glucagon secretion by noradrenaline.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01223023
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