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  • 1
    Electronic Resource
    Electronic Resource
    THE DECOMPOSITION OF NITROGEN PENTOXIDE BY LIGHT* (1926)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 48 (1926), S. 2837-2839 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01690a012
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  • 2
    Electronic Resource
    Electronic Resource
    Management of erosive lichen planus with topical tacrolimus and recurrence secondary to metoprolol (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Metoprolol, a widely prescribed β-adrenergic receptor blocker, has occasionally been associated with a diversity of cutaneous reactions. We present a 79-year-old male patient with erosive lichen planus (LP) on the feet and hands who was successfully treated with topical tacrolimus. Six months after the lesions had been cured the patient received the β-receptor blocker metoprolol for the treatment of hypertonus. Within only 2 weeks of metoprolol intake the erosive lesions on the palms and feet recurred. After discontinuation of the drug and repetitive topical treatment with tacrolimus a complete remission of the lesions could be achieved. The recurrence of erosive LP probably secondary to metoprolol and the therapeutic success of topical tacrolimus in the treatment of LP are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2004.01116.x
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  • 3
    Electronic Resource
    Electronic Resource
    Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Recent studies have shown that collagen-degrading matrix metalloproteinase (MMP)-1 and MMP-3 are produced by fibroblasts in response to photodynamic therapy (PDT) with 5-aminolaevulinic acid (ALA) and are considered to be involved in the antisclerotic effects of ALA-PDT observed in the treatment of localized scleroderma.Objectives  As the primary target of topical PDT is epidermal keratinocytes, we studied the indirect participation of keratinocytes in the production of MMPs and collagen by dermal fibroblasts.Methods  Keratinocytes were treated with sublethal doses of ALA (100 µmol L−1) and red light. The conditioned media were collected 24 h after PDT and primary human fibroblasts were exposed to these media for 6–48 h. Further, a coculture model, keratinocytes seeded on to collagen type IV-coated transwells in the upper chamber and fibroblasts in the lower chamber, was used to study paracrine effects of keratinocytes after PDT.Results  Keratinocyte supernatants after PDT showed a significant, up to 10-fold increase of interleukin (IL)-1α and a 2·5-fold increase of tumour necrosis factor-α as determined by enzyme-linked immunosorbent assay, while IL-6, MMP-1 and MMP-3 were not altered significantly. Fibroblasts treated with keratinocyte-conditioned media after PDT showed an induction of MMP-1 and MMP-3 protein levels up to threefold in both models used, suggesting that ALA-PDT modulates MMP-1 and MMP-3 production via indirect mechanisms. Collagen type I mRNA expression by fibroblasts was not altered significantly in either model. The addition of an IL-1 receptor antagonist to the keratinocyte-conditioned media completely inhibited the induction of MMP-1 and MMP-3 in stimulated fibroblasts, suggesting that IL-1 is mainly responsible for the observed paracrine effects.Conclusions  We present evidence that PDT can trigger MMP production in dermal fibroblasts not only directly as has been already shown, but also by an indirect paracrine loop mediated by soluble factors released by epidermal keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06209.x
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  • 4
    Electronic Resource
    Electronic Resource
    Epidermodysplasia verruciformis treated using topical 5-aminolaevulinic acid photodynamic therapy (1999)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a 65-year-old woman who had had wart-like lesions on the hands, lower arms and forehead for about 45 years. She had already had several basal cell carcinomas excised. Histological study, electron microscopy and in situ hybridization [human papilloma virus (HPV)-types 5/8/12/14/19–23/25/36] of skin biopsies confirmed a diagnosis of epidermodysplasia verruciformis (EV). Photodynamic therapy (PDT) was performed using a 20% 5-aminolaevulinic acid ointment applied for 6 h to the lesions and irradiating using an incoherent light source (λ = 580–740 nm, 160 mW/cm2, 160 J/cm2). Following PDT, blistering and crusting of the lesions occurred, but these healed completely within 2–3 weeks without scarring, and the cosmetic result was excellent. Six months after PDT a skin biopsy was taken. In situ hybridization was positive for HPV type 8 in skin which was clinically and histologically normal. Twelve months after PDT a few lesions had recurred on the hands. Although permanent cure of EV cannot be achieved by any therapy at present and single lesions continue to appear in this patient, topical PDT might result in better control of HPV-induced lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.02830.x
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  • 5
    Electronic Resource
    Electronic Resource
    Glass Pressure Gage (1922)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 14 (1922), S. 1015-1015 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50155a007
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  • 6
    Electronic Resource
    Electronic Resource
    Ehlers-Danlos type VIII (2000)
    Springer
    Clinical oral investigations 4 (2000), S. 66-69 
    Details
    ISSN: 1436-3771
    Keywords: Key words Periodontitis ; Gingival recession ; Abnormal scarring ; Early tooth loss ; Ehlers-Danlos syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ehlers-Danlos type VIII is a rare disorder characterized by soft, hyperextensible skin, abnormal scarring, easy bruising, and generalized periodontitis with early loss of teeth. To illustrate the clinical dermatological and dental features, we present the case history of a 20-year-old patient who has suffered from poor healing of wounds at the shins and knees since childhood, which have developed into hyperpigmented atrophic scars. In the course of orthodontic treatment during the last 3 years, severe apical root resorption, gingival recession, and loss of alveolar bone were observed. Family history was noncontributory for any skin or tooth disorders. The typical clinical signs confirmed the diagnosis of Ehlers-Danlos syndrome type VIII. As there is no specific treatment for the disorder, management is limited to the symptomatic treatment of the dental disease. It seems advisable to consider carefully the indications for orthodontic treatment in patients with Ehlers-Danlos type VIII syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840050117
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  • 7
    Electronic Resource
    Electronic Resource
    Fluoreszenzgestützte Biopsie von Basalzellkarzinomen (2000)
    Springer
    Der Hautarzt 51 (2000), S. 920-924 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Basalzellkarzinom ; Fluoreszenz ; Biopsie ; 5-Aminolävolinsäure ; Digitale Bilderarbeitung ; Keywords Basal cell carcinoma ; Fluorescence ; Biopsy ; 5-Aminolaevulinic acid ; Digital Imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and Objective. The diagnosis of precancerous and cancerous skin leasons in pretreated or scarred skin can be difficult. The determination of the right biopsy site in a suspected area depends largely on the physician's experience. Patients/Methods. The possibility of using a CCD-camera system and measuring tumor fluorescence following topical application of 5-aminolevulinic acid was employed in a single case to facilitate accurate choice of biopsy site. Results. An user-independent evaluation of the induced fluorescence intensity was achieved by means of the described optical system and digital imaging. The contrast of the acquired fluorescence images can be significantly enhanced and allows the determination of a threshold. As result an initial, clinically not visible basal cell carcinoma was detected and excised by a punch biopsy in toto. Conclusions. Using the described optical system the early recognition of a superficial basal cell carcinoma and the determination of the exact biopsy site was achieved in pretreated skin. The routine employment of the system will be assessed in a prospective study.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Die Diagnose von präkanzerösen oder kanzerösen Hautveränderungen in vorbehandelten oder vernarbten Arealen kann oft sehr schwierig sein. Insbesondere hängt die richtige Wahl der Entnahmestelle von Gewebeproben zum Malignitätsausschluss von der Erfahrung des behandelnden Arztes ab. Patienten/Methodik. In dieser Arbeit soll anhand eines Fallberichtes dargestellt werden, wie durch die Verwendung eines CCD-Kamera-Systems und der Fluoreszenzdiagnostik nach topischer Applikation von 5-Aminolävulinsäure eine gezielte Entnahme von Gewebeproben stattfinden kann. Ergebnisse. Mithilfe des verwendeten optischen Systems und digitaler Bildverarbeitung wurde eine benutzerunabhängige Bewertung der gemessenen Fluoreszenzintensitäten möglich. Zudem konnte der Kontrast in den Fluoreszenzbildern entscheidend verstärkt und ein Schwellwert für einen Malignitätsverdacht festgelegt werden. Im vorliegenden Fall konnte so ein initiales, subklinisches Basalzellkarzinom detektiert werden, das bei der anschließenden Biopsie in toto exzidiert wurde. Schlussfolgerungen. Durch das vorgestellte System sind eine frühzeitige Erkennung von oberflächlichen Basalzellkarzinomen und eine gezielte Gewebeentnahme möglich. Die routinemäßige Einsetzbarkeit des Systems wird in einer größer angelegten Studie überprüft werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051240
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  • 8
    Electronic Resource
    Electronic Resource
    Experience with the early treatment of childhood haemangiomata using the flashlamp-pumped dye laser (1996)
    Springer
    Lasers in medical science 11 (1996), S. 181-183 
    Details
    ISSN: 1435-604X
    Keywords: Haemangiomata of childhood ; Laser therapy ; Pulsed dye laser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Small cutaneous haemangiomata of infancy respond well to treatment with the flashlamp-pumped dye laser (FPDL). Optimum use of laser parameters can produce a regression in over 75% of such lesions. In very early lesions, a complete resolution can be achieved in up to 55% of cases. Since this therapy is quick and effective, and side-effects are minimal, FPDL treatment of all haemangiomas of infancy presenting early should be recommended, even if progression to deep haemangiomas cannot be prevented in all cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02156761
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  • 9
    Electronic Resource
    Electronic Resource
    New Laser Literature (1998)
    Springer
    Lasers in medical science 13 (1998), S. 82-84 
    Details
    ISSN: 1435-604X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592964
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  • 10
    Electronic Resource
    Electronic Resource
    Photodynamic Inactivation of Staphylococci with 5-Aminolaevulinic Acid or Photofrin (1999)
    Springer
    Lasers in medical science 14 (1999), S. 54-61 
    Details
    ISSN: 1435-604X
    Keywords: Keywords: 5-Aminolaevulinic acid; Dye laser; Gram positive bacteria; Photodynamic therapy; Photofrin; Protoporphyrin IX; Wound infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. Widespread use of antibiotics for bacterial infections is a reason for antibiotic resistance. Therefore, alternatives like photodynamic therapy (PDT) are studied for bacterial eradication. The viability of Staphylococcus (S.) aureus and S. epidermidis was studied following photosensitisation with different concentrations of 5-aminolevulinic acid (5-ALA) or Photofrin® and irradiation with a dye laser. After ALA without irradiation growth of S. epidermidis was reduced, surprisingly growth of S. aureus significantly increased. Using ALA and light a significant and concentration-dependent decrease of bacterial growth was measured in both strains. However, for S. epidermidis there was no difference between ALA with or without irradiation. Photofrin without light decreased bacterial growth significantly, indicating a high dark toxicity of the drug. Photofrin and light lead to a highly significant reduction of growth in both strains. While 5-ALA killed only up to 39% of Staphylococci, Photofrin was able to eradicate up to 93% of the bacteria. The poor response to 5-ALA may be due to an insufficient synthesis of photodynamically active porphyrins in Staphylococci. Although topical PDT could be useful for superinfected wounds or leg ulcers, the in-vitro bactericidal effect of 5-ALA PDT on staphylococci was not satisfactory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101030050021
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