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  • 1
    Electronic Resource
    Electronic Resource
    The relationship between politicians and administrators – a logic of disharmony (2002)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Public administration 80 (2002), S. 0 
    Details
    ISSN: 1467-9299
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Political Science , Economics
    Notes: The relationship between politicians (elected officials) and administrators (appointed officials) is the cornerstone to understanding the governing process and has always been highly debated in the public administration literature. Traditionally, the debate focuses on Weber’s clear separation between politicians and administrators and a criticism of the basic assumptions of Weber’s model. An alternative model is the Dichotomy–Duality–Model which gives a more varied description of the relationship between politicians and administrators. This article argues that in order to get a more thorough understanding of the complicated interaction between politicians and administrators, it is necessary to pay attention to the two groups’ logic of action. It is argued that politicians are driven by inductive logic of action while administrators are influenced by a deductive logic of action. These two opposites create a logic of disharmony between the two agents. Empirical findings from counties in Denmark support the present and the resistance of the logic, since management tools designed to create a harmonious relationship between politicians and administrators are unable to change the logic of disharmony.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-9299.00326
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  • 2
    Electronic Resource
    Electronic Resource
    Reversibility of airway inflammation and remodelling following cessation of antigenic challenge in a model of chronic asthma (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Asthma is associated with recruitment of eosinophils, accumulation of chronic inflammatory cells in the airway walls, subepithelial fibrosis and other structural changes of airway wall remodelling. The role of ongoing exposure to allergens in their pathogenesis remains unclear.Objective To examine whether changes of inflammation and remodelling were reversible following cessation of antigenic challenge in a mouse model of chronic asthma.Methods BALB/c mice sensitized to ovalbumin (OVA) were chronically challenged by inhalation of a low mass concentration of antigen for 8 weeks, leading to development of acute-on-chronic airway inflammation, subepithelial fibrosis and other changes of airway wall remodelling. Epithelial injury was assessed by immunohistochemistry, while inflammation and remodelling were quantified by appropriate histomorphometric techniques. Regression of lesions was assessed in animals examined at 1, 2 and 4 weeks after exposure to OVA ceased.Results We did not find evidence of airway epithelial injury in this model of low-level chronic inhalational exposure to antigen. Persistence of the recruitment of eosinophils and chronic inflammatory cells in the airway walls was dependent on continuing antigenic challenge, as was persistence of mucous cell hyperplasia/metaplasia. Subepithelial fibrosis and epithelial hypertrophy exhibited delayed reversibility following cessation of exposure to antigen, possibly related to matrix-associated accumulation of transforming growth factor-β1.Conclusion In chronic asthma, low-level antigenic challenge may be required to maintain the inflammatory response in the airway wall, but airway remodelling may persist in its absence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.02097.x
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  • 3
    Electronic Resource
    Electronic Resource
    Increased surfactant protein D in rat airway goblet and Clara cells during ovalbumin-induced allergic airway inflammation (2002)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Structural remodelling of airways in asthma that follows inflammation may be affected by surfactant protein D (SP-D)-mediated effects on the immune response.Objective To determine potential sites of SP-D interaction with the pulmonary immune response, we examined the distribution of immunoreactive SP-D in an experimental model of allergen-induced airway inflammation using immunohistochemistry, biochemical methods and in situ hybridization.Methods The experimental model used subcutaneous injection of ovalbumin in adult rats, which induced an airway response to inhaled nebulized ovalbumin. Three groups of rats (ovalbumin, ovalbumin + dexamethasone and saline) were challenged thrice weekly for 3 weeks. A fourth group of seven rats (naive) were taken from the same delivery of rats as the other groups. Lungs were then lavaged to determine total cell count, eosinophil count, ovalbumin-specific IgE by enzyme-linked immunosorbent assay and SP-D by immunoblot. Tissue samples were fixed and embedded, and sections were studied for the infiltration of eosinophils and for expression of SP-D protein by histochemistry and mRNA by in situ hybridization.Results Ovalbumin induced perivascular and peribronchiolar eosinophilia which could be prevented by dexamethasone treatment. In addition, the ovalbumin-specific IgE levels in serum and bronchoalveolar lavage fluid of ovalbumin-challenged animals were enhanced. Increased amount of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and, surprisingly, in hyperplastic goblet cells of inflamed lungs was found. SP-D mRNA was detected in goblet cells as well as in type II pneumocytes and Clara cells. Dexamethasone treatment did not affect level of SP-D immunoreactivity.Conclusion SP-D accumulation is increased in this model of allergen-induced eosinophilia, both in upper and lower airways. The increase is unaffected by dexamethasone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2745.2002.01423.x
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  • 4
    Electronic Resource
    Electronic Resource
    Diagnosis of antibody-mediated drug allergy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Based on the l-phenyl-2,3-dimethyl-3-pyraizolin-5-one series and on the 1,2-diphenyl-pyrazolidine-3,5-dione series of drugs, haptenic reagents and conjugates were synthesized and evaluated by passive cutaneous anaphylaxis in guinea pigs, and by ELISA tests using rabbit antisera against the haptens. No cross-reactivity between pyrazolinone and pyrazolidinedione haptenic reagents was found in any of the test systems. But also within each series, the animal antibodies showed rather strict specificities upon interaction with related haptens or drugs. These results are somewhat unexpected, because the haptens were used in connection with long and flexible spacer arms. Furthermore, they are not typical for certain other drug allergies. The strict specificity reduces the diagnostic potential of the haptenic reagents when used in serological tests or in skin testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb00390.x
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  • 5
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    Unknown
    Unclassifieds (1990)
    Boston, Mass., etc. : Periodicals Archive Online (PAO)
    The North American Review. 275:4 (1990:Dec.) 31 
    Details
    ISSN: 0029-2397
    Topics: English, American Studies , History
    Notes: DEPARTMENTS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3197-1990-275-04-000012
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  • 6
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    Unknown
    Foreign Correspondence: NOTES MADE WHILE TRANSLATING POETRY FOR AN ENGLISH LANGUAGE ANTHOLOGY, IN POLAND, JUNE 1993 (1994)
    Boston, Mass., etc. : Periodicals Archive Online (PAO)
    The North American Review. 279:2 (1994:Mar./Apr.) 46 
    Details
    ISSN: 0029-2397
    Topics: English, American Studies , History
    Notes: DEPARTMENTS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3197-1994-279-02-000013
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous determination of L-693,612, a topical carbonic anhydrase inhibitor, and two potential metabolites in human whole blood by ion-pair high-performance liquid chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 660 (1994), S. 307-312 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0021-9673(94)85126-3
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  • 8
    Electronic Resource
    Electronic Resource
    The reaction of the azide ion with VCl"3 and NbCl"5
    Amsterdam : Elsevier
    Inorganic and Nuclear Chemistry Letters 10 (1974), S. 443-447 
    Details
    ISSN: 0020-1650
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0020-1650(74)80124-8
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  • 9
    Electronic Resource
    Electronic Resource
    Time dependence of the expression of ICAM-1 (CD 54) in human skin wounds (1997)
    Springer
    International journal of legal medicine 110 (1997), S. 299-304 
    Details
    ISSN: 1437-1596
    Keywords: Key words ICAM-1 ; CD 54 ; Wound age ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract To characterize the vitality and age of skin wounds by means of the ICAM-1 pattern, 157 intravital human skin wounds (time since injury ranging from 5 min to 730 days) were immunohistochemically investigated. ICAM-1 was detected in paraffin sections after autoclaving and using the ABC technique in 86% of the wounds investigated. The correlation between ICAM-1 expression and the degree of wound inflammation is weak. Strong positive staining was observed 1.5 h at the earliest and 3.5 days at the latest after the time of injury. ICAM-1 also appeared at low concentrations in samples of uninjured skin (n = 65), on keratinocytes and the endothelial cells of blood vessels. Moderate to strong ICAM-1 expression is a valuable indication of the vitality of the wound. However, at present the detection of ICAM-1 alone is not sufficient to fix the wound age with the accuracy which is required for forensics applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050092
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison of the immunohistology of mucosa-associated lymphoid tissue in the larynx and lungs in cases of sudden infant death and controls (1997)
    Springer
    International journal of legal medicine 110 (1997), S. 316-322 
    Details
    ISSN: 1437-1596
    Keywords: Key words Bronchus-associated lymphoid tissue ; (BALT) ; Larynx-associated lymphoid tissue (LALT) ; Respiratory mucosal immunity ; Sudden infant ; death/syndrome (SID/S) ; Young children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The respiratory tract of children in the first two years of life, unlike that of adults, contains bronchus-associated lymphoid tissue (BALT) and larynx-associated lymphoid tissue (LALT) with no differences in frequency between SID and control children. Using immunohistochemical methods we examined the distribution of B, T, CD4+ and CD8+ lymphocytes, HLA-D+ cells, CD68+ macrophages and proliferating cells, comparing bronchus-associated and larynx-associated lymphoid tissue of sudden infant death cases and controls. In all groups the lymphoid tissue was organized in lymphoid follicles and parafollicular areas. With no differences in the cellular composition of BALT and LALT the lymphoid follicles contained mainly B lymphocytes with some CD4+ lymphocytes in the germinal centers. Remarkably T lymphocytes of both subset types and B lymphocytes were observed in equal numbers in the parafollicular areas in contrast to gut-associated lymphoid tissue. However, the respiratory tract of young children with no differences between SID and controls might play a similar role in mucosal immunity and might function as an inductive site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050095
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