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  • 1
    Electronic Resource
    Electronic Resource
    Integrated Design for Mammalian Cell Culture (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 409-413 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Training programs in bio-process techniques provide the basic tools, but devel oping the art of integrating these techniques into a total protein production system comes only through experience. Through its long involvement in setting up and optimizing protein pharmaceutical production schemes, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0590-409
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Toward Efficient Agnostic Learning (1994)
    Springer
    Machine learning 17 (1994), S. 115-141 
    Details
    ISSN: 0885-6125
    Keywords: machine learning ; agnostic learning ; PAC learning ; computational learning theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In this paper we initiate an investigation of generalizations of the Probably Approximately Correct (PAC) learning model that attempt to significantly weaken the target function assumptions. The ultimate goal in this direction is informally termed agnostic learning, in which we make virtually no assumptions on the target function. The name derives from the fact that as designers of learning algorithms, we give up the belief that Nature (as represented by the target function) has a simple or succinct explanation. We give a number of positive and negative results that provide an initial outline of the possibilities for agnostic learning. Our results include hardness results for the most obvious generalization of the PAC model to an agnostic setting, an efficient and general agnostic learning method based on dynamic programming, relationships between loss functions for agnostic learning, and an algorithm for a learning problem that involves hidden variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022615600103
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Toward efficient agnostic learning (1994)
    Springer
    Machine learning 17 (1994), S. 115-141 
    Details
    ISSN: 0885-6125
    Keywords: machine learning ; agnostic learning ; PAC learning ; computational learning theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In this paper we initiate an investigation of generalizations of the Probably Approximately Correct (PAC) learning model that attempt to significantly weaken the target function assumptions. The ultimate goal in this direction is informally termedagnostic learning, in which we make virtually no assumptions on the target function. The name derives from the fact that as designers of learning algorithms, we give up the belief that Nature (as represented by the target function) has a simple or succinct explanation. We give a number of positive and negative results that provide an initial outline of the possibilities for agnostic learning. Our results include hardness results for the most obvious generalization of the PAC model to an agnostic setting, an efficient and general agnostic learning method based on dynamic programming, relationships between loss functions for agnostic learning, and an algorithm for a learning problem that involves hidden variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00993468
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation (1990)
    Springer
    Cytotechnology 3 (1990), S. 295-299 
    Details
    ISSN: 1573-0778
    Keywords: large-scale cultivation ; monoclonal antibodies ; therapeutic proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1×107 cells/ml with concomitant increase in product concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365493
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    Paper (German National Licenses)
    Fulltext
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