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  • 1
    Electronic Resource
    Electronic Resource
    The effect of short-term glucagon infusion on kidney function in normal man (1977)
    Springer
    Diabetologia 13 (1977), S. 323-325 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; functional diabetic microan-giopathy ; glucagon ; kidney function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Kidney function was studied in six normal males before and during a 2 h glucagon (10 ng/kg/min) infusion. The following variables were determined during each 20 min clearance period; glomerular filtration rate (GFR), renal plasma-flow (RPF), filtration fraction (FF), urinary albumin andβ 2-microglobulin-excretion rates. Glucagon infusion resulted in a fourfold increase in plasma glucagon concentration. The infusion induced a significant increase in GFR (+9%), FF (+ 9%) and urinaryβ 2-microglobulin excretion rate (+ 32%), (p〈0.01). RPF and urinary albumin excretion rates were not significantly changed. We suggest that glucagon may contribute to the reversible kidney function alterations typically found in poorly regulated juvenile diabetes, a state with relative or absolute hyperglucagonaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223273
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Establishment of a national Danish hernia data base: preliminary report (1999)
    Springer
    Hernia 3 (1999), S. 81-83 
    Details
    ISSN: 1248-9204
    Keywords: Inguinal hernia ; Quality assurance ; Data base
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Despite improvements in hernia surgery, there are still unsolved problems, especially when operations are performed outside dedicated hernia centres: reduction of recurrence rates, selection of the optimal anesthesia, reduction of length of stay and formulation of evidence based convalescence recommendations. Most of these problems can only be solved through collaboration and multicenter studies. By setting up a national clinical data base for hernia surgery, we aim to establish a scientific basis for the surgical practise in hernia surgery, based on two parallel strategies: 1) to collect nation wide information on the relation between the procedures performed and rates of operation for recurrence, choice of anesthesia and length of stay and 2) to use the data base collaboration to establish multicenter prospective clinical trials. A simple, inexpensive and functional data base was developed and started registration on 1. Jan 1998, with current participation of departments and outpatient clinics, performing approximately 95% of hernia repairs in Denmark. Presently, 3 prospective multicenter studies are under development. A national Danish hernia data base is in function and has the potential to monitor and improve current practise in hernia surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194610
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Disruption of colonic anastomosis during continuous epidural analgesia (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 40 (1985), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinical presentation is described of partial rupture of a colonic anastomosis two hours after surgery during epidural analgesia. The unusually early presentation of this complication is possibly due to removal of normal intestinal sympathetic activity by epidural analgesia resulting in normal or increased colonic motility. It is not known whether epidural analgesia may precipitate anastomotic breakdown due to increased contractions and strain on the anastomosis, or lead to an earlier presentation of a disruption caused by failure of surgical technique or other factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb10755.x
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of posture on late postoperative oxygenation (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twelve patients had their arterial oxygen saturation measured pre-operatively and on days 1, 4 and 7 after laparotomy. Measurements were performed in the supine, sitting and standing positions on each day. Arterial oxygen saturation was significantly higher during sitting and standing on days 1 and 4 after operation compared with the supine position (p 〈 0.05). These results give further evidence for the benefits of patient mobilisation after major surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1996.tb13637.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Oxygen therapy reduces postoperative tachycardia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 50 (1995), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Concomitant hypoxaemia and tachycardia in the postoperative period is unfavourable for the myocardium. Since hypoxaemia per se may be involved in the pathogenesis of postoperative tachycardia, we have studied the effect of oxygen therapy on tachycardia in 12 patients randomly allocated to blinded air or oxygen byfacemask on the second or third day after major surgery. Inclusion criteria were arterial hypoxaemia (oxygen saturation ≤ 92%) and increased heart rate (〉 90 beat.min-1). Each patient responded similarly to oxygen therapy: an increase in arterial oxygen saturation and a decrease in heart rate (p 〈 0.002). Thus, postoperative supplementary oxygen has a positive effect on the cardiac oxygen delivery and demand balance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1995.tb06109.x
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  • 6
    Electronic Resource
    Electronic Resource
    The feasibility, safety and cost of infiltration anaesthesia for hernia repair[Interim re] (1998)
    Oxford : Blackwell Science Ltd, UK
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Data from 400 consecutive elective ambulatory operations for inguinal hernia under unmonitored local anaesthesia with limited pre-operative testing were prospectively obtained by the use of standardised files and questionnaires to assess the feasibility, patient satisfaction and potential cost reductions for such a technique. The median age of the patients was 59 years, and 29 operations were performed in ASA group III patients. The median postoperative hospital stay was 85 min. Conversion to general anaesthesia was necessary only in two cases, and nine patients needed overnight admission. One week postoperative morbidity was low with one case of transient cerebral ischaemia and one case of pneumonia, but no case of urinary retention. On follow-up, 88% were satisfied with the procedure, including unmonitored local anaesthesia. The cost reduction was at least £160 per patient compared with general/regional anaesthesia. We conclude that elective inguinal herniorrhaphy may be performed routinely under unmonitored local anaesthesia with a low postoperative morbidity, a high satisfaction rate and significant cost reductions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1998.00244.x
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  • 7
    Electronic Resource
    Electronic Resource
    Body position and late postoperative nocturnal hypoxaemia (1997)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirteen patients were monitored for nocturnal body position (supine vs. side) and arterial oxygen saturation pre-operatively and on the second postoperative night after major abdominal surgery. The number of positional changes were significantly decreased after operation (p 〈 0.05) with a trend towards more time spent in the supine position (p = 0.1). Individual mean arterial oxygen saturation decreased postoperatively (p 〈 0.05) but without a difference between the supine and side positions (p = 0.9). Pre-operatively, episodic desaturations were significantly more frequent in the supine position than on the side (p 〈 0.05) but not postoperatively. Pain was the most frequent reason for decreased nocturnal movements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.128-az0124.x
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of the Nellcor N-200 and N-3000 pulse oximeters during simulated postoperative activities (1997)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-six healthy volunteers were monitored simultaneously with the Nellcor N-200 and N-3000 pulse oximeters during nonhypoxaemic simulated postoperative activity. The overall number of registered events (hypoxaemic episodes or loss of signal) was fewer with the N-3000 than with the N-200 (8 vs. 32, p 〈 0.00005). Episodes of ‘desaturation’ of ≥5% from baseline were significantly fewer with the N-3000 than with the N-200 (5 vs. 19, p =0.0001), and lowest values below 90% occurred nine times on the N-200, but were not seen with the N-3000 (p 〈0.00005). Furthermore, episodes owing to loss of signal were significantly rarer with the N-3000 than with the N-200 (3 vs. 13, p =0.001). The Nellcor N-3000 oximeter may offer an advantage over the N-200 model when monitoring patients in the postoperative period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1997.027-az026.x
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  • 9
    Electronic Resource
    Electronic Resource
    Ventilatory pattern and associated episodic hypoxaemia in the late postoperative period in the general surgical ward (1999)
    Oxford : Blackwell Science Ltd
    Anaesthesia 54 (1999), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Episodic oxygen desaturation is frequent in the late postoperative period and seems most pronounced on the second and third postoperative nights. However, the ventilatory pattern has not been described systematically during this period. We studied the ventilatory pattern and associated arterial oxygenation using the Edentrace II equipment (impedance pneumography and pulse oximetry) on the second and third postoperative nights in 28 patients undergoing major abdominal surgery. Ventilatory disturbances were common and included periods of hypopnoea, and obstructive, central and mixed apnoeas. Overall, the median (range) respiratory disturbance index (apnoeas + hypopnoeas per h) was 12 (0–121), with the patients spending 6% (0–65%) of the night in some kind of ventilatory disturbance. It was not possible from pre-operative snoring habits to predict patients who developed postoperative ventilatory disturbances. Overall, 23% (0–100) of the hypopnoeas and 7% (0–100) of the apnoeas were associated with episodic hypoxaemia. In conclusion, ventilatory disturbances were common in the late postoperative period in the general surgical ward and often associated with episodes of oxygen desaturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1999.00744.x
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  • 10
    Electronic Resource
    Electronic Resource
    Pain after microlaparoscopic cholecystectomy (2000)
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 340-344 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Gallbladder — Microlaparoscopic cholecystectomy — Pain — Randomized controlled trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Laparoscopic cholecystectomy (LC) is traditionally performed with two 10-mm and two 5-mm trocars. The effect of smaller port incisions on pain has not been established in controlled studies. Methods: In a double-blind controlled study, patients were randomized to LC or cholecystectomy with three 2-mm trocars and one 10-mm trocar (micro-LC). All patients received a multimodal analgesic regimen, including incisional local anesthetics at the beginning of surgery, NSAID, and paracetamol. Pain was registered preoperatively, for the first 3 h postoperatively, and daily for the 1st week. Results: The study was discontinued after inclusion of 26 patients because five of the 13 patients (38%) randomized to micro-LC were converted to LC. In the remaining 21 patients, overall pain and incisional pain intensity during the first 3 h postoperatively increased in the LC group (n= 13) compared with preoperative pain levels (p 〈 0.01), whereas pain did not increase in the micro-LC group (n= 8). Conclusions: Micro-LC in combination with a prophylactic multimodal analgesic regimen reduced postoperative pain for the first 3 h postoperatively. However, the micro-LC led to an unacceptable rate of conversion to LC (38%). The micro-LC instruments therefore need further technical development before this surgical technique can be used on a routine basis for laparoscopic cholecystectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004640020014
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    Paper (German National Licenses)
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