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  • 1
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The effects of guanine nucleotides on binding of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX), a highly selective A1 adenosine receptor antagonist, have been investigated in rat brain membranes and solubilized A1 receptors. GTP, which induces uncoupling of receptors from guanine nucleotide binding proteins, increased binding of [3H]DPCPX in a concentration-dependent manner. The rank order of potency for different guanine nucleotides for increasing [3H]DPCPX binding was the same as for guanine nucleotide-induced inhibition of agonist binding. Therefore, a role for a guanine nucleotide binding protein, e.g., Gi, in the regulation of antagonist binding is suggested. This was confirmed by inactivation of Gi by N-ethylmaleimide (NEM) treatment of membranes, which resulted in an increase in [3H]DPCPX binding similar to that seen with addition of GTP. Kinetic and equilibrium binding studies showed that the GTP- or NEM-induced increase in antagonist binding was not caused by an affinity change of A1 receptors for [3H]DPCPX but by an increased Bmax value. Guanine nucleotides had similar effects on membrane-bound and solubilized receptors, with the effects in the solubilized system being more pronounced. In the absence of GTP, when most receptors are in a high-affinity state for agonists, only a few receptors are labeled by [3H]DPCPX. It is suggested that [3H]DPCPX binding is inhibited when receptors are coupled to Gi. Therefore, uncoupling of A1 receptors from Gi by guanine nucleotides or by inactivation of Gi with NEM results in an increased antagonist binding.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Antipode 34 (2002), S. 0 
    ISSN: 1467-8330
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geographie
    Notizen: This paper analyses recent developments in urban planning in the City of Toronto. A municipality of 2.4 million inhabitants that makes up the inner half of the Greater Toronto Area, the City of Toronto was consolidated from seven municipalities in 1998. Planning practice, discourse, and “vision” in the new City of Toronto are shaped by the city’s bid for the 2008 Olympics, related proposals for waterfront redevelopment, and preparations for a new official plan. In the context of comparative debates on trends in local governance, we see current planning strategies in Toronto as one of several strategic sites in which Toronto is consolidated into a “competitive city.” Historically, the formation of the competitive city in Toronto must be seen as a result of the impasse of postwar metropolitan planning in the early 1970s, the sociospatial limitations of downtown urban reform politics in the 1970s and 1980s, and the neoliberal restructuring and rescaling of the local state in the 1990s. Theoretically, we draw on the global city research paradigm, regime and regulation theory, and neo-Gramscian urban political theory to suggest that planning the competitive city signals shifts in the sociopolitical alliances, ideological forms, and dominant strategies that regulate global-city formation. These constellations and strategies threaten to reconstitute bourgeois hegemony in Toronto with a series of claims to urbanity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Antipode 34 (2002), S. 0 
    ISSN: 1467-8330
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geographie
    Notizen: This paper argues that urban neoliberalism can best be understood as a contradictory re–regulation of urban everyday life. Based on an analysis of neoliberalism as a new political economy and as a new set of technologies of power, the paper argues that the urban everyday is the site and product of the neoliberal transformation. Governments and corporations play a key role in redefining the conditions of everyday life through neoliberal policies and business practices. Part of this reorientation of everydayness, however, involves new forms of resistance and opposition, which include the kernel of a possible alternative urbanism. The epochal shift from a Keynesian–Fordist–welfarist to a post–Fordist–workfarist society is reflected in a marked restructuring of everyday life. The shift changes the socioeconomic conditions in cities. It also includes a reorientation of identities, social conflicts, and ideologies towards a more explicitly culturalist differentiation. Social difference does not disappear, but actually becomes more pronounced; however, it gets articulated in or obscured by cultural terms of reference.The paper looks specifically at Toronto, Ontario, as a case study. An analysis of the explicitly neoliberal politics of the province’s Progressive Conservative (Tory) government under Mike Harris, first elected in 1995, demonstrates the pervasive re–regulation of everyday life affecting a wide variety of people in Toronto and elsewhere. Much of this process is directly attributable to provincial policies, a consequence of Canada’s constitutional system, which does not give municipalities autonomy but makes them “creatures of provinces.” However, the paper also argues that Toronto’s elites have aided and abetted the provincial “Common–Sense” Revolution through neoliberal policies and actions on their own. The paper concludes by outlining the emergence of new instances of resistance to the politics of hegemony and catastrophe of urban neoliberalism.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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