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  • 1
    Electronic Resource
    Electronic Resource
    Immunocytochemical characterization of catecholaminergic neurons in the rat striatum following dopamine-depleting lesions (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is possible either permanently or transiently to deplete the rat striatum of dopamine. Following such depletions, striatal neurons immunoreactive for tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC) or dopamine appear. The presence of dopamine-producing neurons in the striatum has relevance for the treatment of Parkinson’s disease, but whether these catecholaminergic phenotypes all produce dopamine is unclear. In the present study we establish that after unilateral 6-hydroxydopamine lesions or methamphetamine administration, striatal TH-immunoreactive neurons differ in size, morphology and location from those that are immunopositive for AADC or dopamine. The TH-positive cells which were localized either to ventral parts of the striatum or to the central and dorsal areas of the caudate-putamen generally have the morphological features of projection neurons, whereas those containing AADC or dopamine were confined to subcallosal positions in the dorsal medial quadrant of the caudate-putamen and resemble small, local-circuit neurons. The fact that AADC-immunoreactive neurons overlap in size, morphology and location with the cells that produce dopamine suggests strongly that this population is dopaminergic. However, the simultaneous appearance of neurons that contain the TH enzyme but clearly do not make dopamine raises questions about the functional role of these cells and the cellular mechanisms responsible for their induction following striatal dopamine loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00774.x
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  • 2
    Electronic Resource
    Electronic Resource
    Removal of the brain for teaching and examination (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 8 (1995), S. 363-365 
    Details
    ISSN: 0897-3806
    Keywords: dissection ; brain ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The brain was removed from cadavers using a modified technique involving additionally the removal of most of the squamous occipital bone and laminae of the upper cervical vertebrae. The resulting specimens were superior to the usual ones in that the medulla oblongata, the upper spinal cord, and all the cranial nerves and cerebral arteries were intact. Fears of slow-virus contamination and legislative changes are precluding the use of brains obtained in the necropsy room for neuroanatomy teaching, so it is paramount that complete brains are removed from dissecting room cadavers. The method described herein takes a little longer than the traditional method, but is within the capability of an anatomy technician and yields better specimens for use in teaching and examinations. © 1995 WiIey-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ca.980080510
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    Paper (German National Licenses)
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