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  • 1
    Electronic Resource
    Electronic Resource
    Five-Coordinate Platinum Olefin Complexes: Synthesis, 1H NMR Investigations, and Crystal Structure of a Platinum .eta.2-Ethylene Crown Ether Complex (1995)
    s.l. : American Chemical Society
    Inorganic chemistry 34 (1995), S. 2788-2790 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00114a043
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  • 2
    Electronic Resource
    Electronic Resource
    Solution Structures and Isomer Distributions of Bis(.beta.-diketonato) Complexes of Titanium(IV) and Cobalt(III) (1994)
    s.l. : American Chemical Society
    Inorganic chemistry 33 (1994), S. 3396-3400 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00093a031
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents (1997)
    Springer
    JBIC 2 (1997), S. 427-432 
    Details
    ISSN: 1432-1327
    Keywords: Key words Water-soluble rutheniumporphyrins ; Artificial nucleases ; DNA cleavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract  Three new water-soluble ruthenium porphyrin complexes have been prepared and characterized, one with a cationic ligand, Ru(TMPyP), and two others with anionic ligands, Ru(p–COOH-PP) and Ru(TPPS). These different complexes and their manganese and iron analogues were tested in vivo as potential antitumor agents with mice bearing P388 leukemia cells, but these complexes have no significant antitumor activity. The nuclease activity of Ru(TMPyP) and Ru(p–COOH-PP) was evaluated on supercoiled plasmid DNA after activation by a reducing agent (ascorbate) in the presence of air or by potassium monopersulfate. No significant activity was evidenced for these ruthenium complexes, in contrast with the already known nuclease activity of the manganese and iron derivatives of TMPyP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007750050153
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  • 4
    Electronic Resource
    Electronic Resource
    Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 195-200 
    Details
    ISSN: 1432-1335
    Keywords: Ruthenium complexes ; Acetoxymethylmethylnitrosamine-induced autochthonous colorectal carcinoma ; Antitumour activity, 5-fluorouracil, leucovorin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antineoplastic activity of the ruthenium complexestrans-imidazolium[tetrachlorobisimidazoleruthenate(III)], HIm(RuIm2Cl4),trans-indazolium-[tetrachlorobis(1H-indazole)ruthenate(III,N 2)], HInd [RuInd2Cl4(N 2)], andtrans-indazolium[tetrachlorobis(2H-indazole)ruthenate(III,N 1)], HInd[RuInd2Cl4-(N1)] was assessed in acetoxymethylmethylnitrosamine-induced autochthonous colorectal carcinomas of Sprague-Dawley rats. The model is not sensitive to clinically established antineoplastic agents, including cisplatin. An exception is the combination therapy with 5-fluorouracil/leucovorin, which shows moderate activity against the tumour model. In contrast to this general trend, the new substances were all active against this tumour. HIm(RuIm2Cl4) was very effective at all dosages applied (7.5 mg/kg, 5.3 mg/kg, and 3.8 mg/kg), as indicated by percentage treated/control (T/C values of 23%, 34.5%, and 44%. Toxicity was considerable as shown by a body weight change of −30%, −19%, and −9%. Nevertheless, the medium dose seems to be the optimum in terms of mortality (0% vs 15% in the control group), whereas at the highest dose, mortality increased as a result of substance toxicity, and at the lowest dose mortality increased through tumor growth combined with substance toxicity. HInd[RuInd2Cl4(N2)] showed high efficacy at the highest dosage of 13 mg/kg, reaching a T/C value of 27% combined with 0% mortality versus 15% in the control group. In equimolar dosages (10 mg/kg, 7.1 mg/kg and 5.1 mg/kg), the compound is not as active as HIm-(RuIm2Cl4), as indicated by T/C values of 50.2%, 45.7%, and 38.6%. HInd[RuInd2Cl4(N1)] was slightly but not significantly better than HInd[RuInd2Cl4(N2)] at a dosage of 7.1 mg/kg and is advantageous over combination therapy with 5-fluorouracil and leucovorin (20/20 mg/kg) in terms of efficacy (T/C=37.6% versus 44.7%) and mortality (6% versus 33.3%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410134
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of Tumor-Inhibiting Complex Salts Containing the Anion trans-Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt (1999)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1999 (1999), S. 1551-1555 
    Details
    ISSN: 1434-1948
    Keywords: Ruthenium ; Coordination chemistry ; Paramagnetic complexes ; Magnetic properties ; Ion exchange ; Antitumor agents ; Colon tumors ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Indazolium trans-tetrachlorobis(indazole)ruthenate(III) exhibits excellent results against different tumor models in vitro and in vivo. To improve the water solubility necessary for the introduction of this tumor-inhibiting compound into clinical trials, we synthesized the corresponding sodium salt in a two-step ion exchange via the tetramethylammonium salt. The sodium salt shows a 35-fold higher solubility in water relative to the indazolium salt. We also synthesized the n-butylammonium, n-octylammonium, and tetraphenylphosphonium salts, all of which showed improved solubility in organic solvents. The X-ray crystal structure of the latter could be solved, proving the trans configuration of the complex anion. In spite of the paramagnetic RuIII center an assignement of the coordinated indazole protons could be made with the help of a COSY experiment.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Calcium Ions Do Accelerate the DNA Binding of New Antitumor-Active Platinum Aminophosphonate Complexes (1999)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1999 (1999), S. 1655-1657 
    Details
    ISSN: 1434-1948
    Keywords: Calcium ; Platinum Complexes ; Aminophosphonate ; Antitumor agents ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The presence of Ca2+ has a marked effect on the reaction kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis-Pt(NH3)2(bmpaa)] and [Pt(R,S-dach)(ntmp)]. The formation of GG-N7,N7 chelates and the release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca2+, which is ascribed to its interaction with the phosphato groups in the ligands.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Struktur von S-9,10-Dimethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantan und 9,10-Diethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantan (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 622 (1996), S. 1097-1100 
    Details
    ISSN: 0044-2313
    Keywords: Organoarsoxane ; S-9,10-Dimethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantane ; 9,10-Diethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantane ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Structure of S-9,10-Dimethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantane and 9,10-Diethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantaneS-9,10-Dimethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantane (1) and 9,10-diethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantane (2) have been prepared by the reaction of propionic acid, propionic anhydride and butyric acid, butyric anhydride, respectively, with arsenic(III)-oxide. The crystals of 1 are rhombic, a = 6.902(4), b = 11.121(5), c = 13.988(8), space group P212121. The crystals of 2 are monoclinic, a = 11.757(10), b = 11.255(10), c = 18.631 (18), β = 91.78(7), space group P21/n. The mean bond lengths and angles in 1 are AsO = 1.790 Å, AsC = 1.959 Å, OAsO = 100.60°, CAsO = 99.65°, AsOAs = 128.77°, AsCAs = 118.73°, and in 2 they are AsO = 1.780 Å, AsC = 1.978 Å, OAsO = 101.45°, CAsO = 99.55°, AsOAs = 129.64°, AsCAs = 117.72°.
    Notes: S-9,10-Dimethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantan (1) und 9,10-Diethyl-1,3,5,7-tetraarsa-2,4,6,8-tetraoxaadamantan (2) wurden durch Umsetzung von Propionsäure und Propionsäureanhydrid bzw. Buttersäure und Buttersäureanhydrid mit Arsenik erhalten. Beide Verbindungen sind strukturanalog zu Arsenolit. Kristalle von 1 sind rhombisch, a = 6.902(4), b = 11.121(5), c = 13.988(8), Raumgruppe P212121. Die Kristalle von 2 sind monoklin, a = 11.757(10), b = 11.255(10), c = 18.631(18), β = 91.78(7), Raumgruppe P21/n. Die Bindungslängen und -winkel in 1 betragen im Mittel AsO = 1.790 Å, AsC = 1.959 Å, OAsO = 100.60°, CAsO = 99.65°, AsOAs = 128.77°, AsCAs = 118.73°. In 2 betragen im Mittel die Bindungslängen und -winkel AsO = 1.780 Å, AsC = 1.978 Å, OAsO = 101.45°, CAsO = 99.55°, AsOAs = 129.64°, AsCAs = 117.72°.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19966220627
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  • 8
    Electronic Resource
    Electronic Resource
    Darstellung und Struktur von Hexa(4-methoxyphenyl)cyclohexaarsanProfessor Walter Siebert zum 60. Geburtstag gewidmet. (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 75-78 
    Details
    ISSN: 0044-2313
    Keywords: Cyclopolyarsane ; Hexa(4-methoxyphenyl)cyclohexaarsane ; Cyclohexaarsane ; Crystal Structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Structure of Hexa(4-methoxyphenyl)cyclohexaarsaneHexa(4-methoxyphenyl)cyclohexaarsane 4 was prepared by the reaction of 4-methoxyphenylarsonic acid with hypophosphorous acid. The structure of 4 was determined by X-ray crystal structure analysis. The crystals of 4 are monoclinic, a = 6.258(6) Å, b = 21.687(19) Å, c = 15.583(14) Å, β = 100.11(7)°, spacegroup P21/c. 4 consists of a six-membered ring in chair conformation and centrical symmetry. The mean bond lengths and angles are As—As = 2.46 Å, As—C = 1.96 Å, As—As—As = 91°, As—As—C = 97°. NMR investigations proved the presence of several species in CDCl3 and C6D6 solutions, respectively.
    Notes: Hexa(4-methoxyphenyl)cyclohexaarsan 4 wurde durch Umsetzung von 4-Methoxyphenylarsonsäure mit Unterphosphoriger Säure erhalten. Die Struktur von 4 wurde durch Kristallstrukturanalyse bestimmt. Kristalle von 4 sind monoklin, a = 6.258 (6) Å, b = 21.687(19) Å, c = 15.583(14) Å, β = 100.11(7)°, Raumgruppe P21/c. 4 besteht aus einem zentrosymmetrischen Sechsring in Sesselkonformation. Die Bindungslängen und -winkel betragen im Mittel As—As = 2.46 Å, As—C = 1.96 Å, As—As—As = 91°, As—As—C = 97°. In CDCl3- bzw. C6D6-Lösungen von 4 konnten mittels NMR mehrere Spezies nachgewiesen werden.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19976230113
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  • 9
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Biologically Active Bismuth(III) Tropolonato Complexes (1995)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 128 (1995), S. 335-342 
    Details
    ISSN: 0009-2940
    Keywords: Tropolone derivatives ; Bismuth complexes ; Helicobacter pylori ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two new types of bismuth(III) tropolonato complexes, nitratobis(tropolonato)bismuth(III) (1d) and phenylbis(tropolonato)bismuthin (1f), are synthesized and characterized by elemental analysis, 1H-NMR, 13C-NMR, IR spectroscopy, and conductivity measurements. The structures of 1d and aquabis(4,5-benzotropolonato)bismuth(III) nitrate (6b) are confirmed by X-ray structural analyses. Derivatives of tropolone (2a) and their bismuth(III) complexes are synthesized and characterized in the same manner. Eight of these compounds are tested against Helicobacter pylori (H.p.) bacteria, which cause chronic gastritis and peptic ulcus. Most of the bismuth compounds show high in vitro activity against H.p.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19951280404
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  • 10
    Electronic Resource
    Electronic Resource
    Struktur eines tumorhemmenden Bipyridyl-Kronenether-PlatinkomplexesDiese Arbeit wurde von der Deutschen Krebshilfe, Dr.-Mildred-Scheel-Stiftung für Krebsforschung, Bonn, und dem Fonds der Chemischen Industrie gefördert. Herrn Dr. Nuber danken wir für die Durchführung der röntgenographischen Messungen. (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 106 (1994), S. 198-200 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19941060211
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