Digitale Medien
Oxford, UK; Malden, USA
:
Blackwell Publishing Ltd/Inc.
Journal of cutaneous pathology
32 (2005), S. 0
ISSN:
1600-0560
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption. The cutaneous lesions occur both in sun-exposed and nonexposed areas in these patients unlike a true HV. In most cases, a latent Epstein-Barr virus (EBV) infection has been detected in the skin lesions of these patients. We performed the photo-provocation test in five patients with an EBV associated HV-like eruption. The photoprovocation tests were caried out using the UVA delivered by a SUPUVASUN 3000 light source. A 5x 5 sqaure cm area on the buttock was irradiated three or four times at 24 hour intervals. A skin biopsy was obtained from the lesional skin and photo-provoked lesion in all five patients. H&E staining and immunohistochemical staining were performed. In situ hybridization was also performed to detect mRNA for EBV in the skin biopsy specimens. Skin lesions were induced by repetitive UVA exposure in all five patients. The severity of the phtoprovoked lesion showed correlation with that of the clinical features. The immunohistologic findings of photo-provoked skin lesions were similar to those of original skin lesions. A latent EBV infection was also demonstrated in the photo-provoked lesion.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.0303-6987.2005.320at.x
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