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  • 1
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 343-346 (May 2000), p. 267-274 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Key words Islet cell-specific 38 kDa autoantigen, immunological effectors, BB rat, autoimmune IDDM.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The diabetic syndrome in the DP-BB rat results from progressive beta-cell destruction by autoimmune responses. However, the initial events causing the autoimmune destruction of beta cells remain largely unknown. Our recent experimental results suggest that the delayed expression of a beta-cell-specific autoantigen may result in the initiation of beta-cell-specific autoimmunity. The present investigation was initiated to identify such an autoantigen. Islets were isolated from DP-BB rats of several different ages, and protein extracts from the membrane fraction of the islet preparations were immunoprecipitated with sera from diabetic DP-BB rats. We have found that a membrane-bound islet cell-specific 38 kDa autoantigen is not expressed early in the life of DP-BB rats, but is delayed-expressed by approximately 30 days of age, the time at which immunological effectors begin to recognize beta cells. In contrast, a 64 kDa islet cell protein is expressed from birth in DP-BB rats. On the basis of these observations, we suggest that delayed expression of a gene encoding for the membrane-bound islet cell-specific 38 kDa autoantigen may result in a breakdown of self-tolerance, leading to beta-cell-specific autoimmune IDDM in the BB rat. [Diabetologia (1994) 37: 460–465]
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Diabetic vascular disease ; diabetes mellitus ; diabetic autonomie neuropathy ; vasomotor nerves ; arterioles ; morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative ultrastructural analysis was made of the terminal innervation of epineurial arterioles in the sural nerve of 6 diabetic and 6 nondiabetic patients of comparable age (mean±SD: 68 ±9 non-diabetic, 65±16 diabetic) with end stage peripheral vascular disease. The results demonstrated specific differences, identifiable morphometrically, in the pattern of innervation of epineurial vessels of diabetics compared with non-diabetics. The differences were: 1) in the diabetic group the proportion of perivascular axons found less than 7 μm from the nearest smooth muscle cell was significantly less than in the non-diabetic group (p 〈0.001); 2), the mean distance of the axons from their effector sites, the vascular smooth muscle cells, was nearly twice as far in the diabetic group compared with the nondiabetic group (p 〈0.05); and 3) the mean absolute number of axons less than 7 μ from the arteriole in the diabetic group was significantly less than in the non-diabetic group (p 〈0.01). These results demonstrate that the neuropathy associated with diabetes mellitus also involves the autonomic terminal innervation of some blood vessels. In addition, this neuropathy selectively affects the vasomotor nerves closer than 7 μm to the media.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Diabetic vascular disease ; diabetes mellitus ; diabetic autonomic neuropathy ; vasomotor nerves ; arterioles ; morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative ultrastructural analysis was made of the terminal innervation of epineurial arterioles in the sural nerve of 6 diabetic and 6 nondiabetic patients of comparable age (mean ± SD: 68 ±9 non-diabetic, 65±16 diabetic) with end stage peripheral vascular disease. The results demonstrated specific differences, identifiable morphometrically, in the pattern of innervation of epineurial vessels of diabetics compared with non-diabetics. The differences were: 1) in the diabetic group the proportion of perivascular axons found less than 7 μm from the nearest smooth muscle cell was significantly less than in the non-diabetic group (p〈0.001); 2) the mean distance of the axons from their effector sites, the vascular smooth muscle cells, was nearly twice as far in the diabetic group compared with the nondiabetic group (p〈0.05); and 3) the mean absolute number of axons less than 7 μm from the arteriole in the diabetic group was significantly less than in the non-diabetic group (p〈0.01). These results demonstrate that the neuropathy associated with diabetes mellitus also involves the autonomic terminal innervation of some blood vessels. In addition, this neuropathy selectively affects the vasomotor nerves closer than 7 μm to the media.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  DNA strand damage, using the single-cell gel electrophoresis (comet) method, was determined in different-stage embryos of grass shrimp (Palaemonetes pugio) collected from surface waters of a local estuary near Savannah, Georgia, USA. Late-stage embryos collected from the estuarine river at midday in the summer or placed in a solar simulator showed extensive DNA strand damage. The solar simulator, which produced the total irradiance found at midday in the summer at 34°N caused DNA strand damage in embryos similar to that found in sunlight-exposed embryos. A large increase in cyclobutane pyrimidine dimers (18 cyclobutane pyrimidine dimers per 1000 kilobases) were detected in DNA from the late-stage embryos exposed to the solar simulator for 1 h (solar irradiance of 126 μW cm−2). DNA repair took place within a few hours when late-stage embryos collected at midday from the river were transferred to the dark. Early grass-shrimp embryo stages showed no DNA strand damage either after placement in the solar simulator or when collected at midday in the summer. This lack of solar-damaged DNA in early-stage embryos was probably due to the presence of high concentrations of carotenoids, which can act as anti-oxidants to prevent damage from activated oxygen species produced by cells exposed to ultraviolet light. These carotenoids are utilized by the developing embryos, and only low concentrations of carotenoids were present in late embryo stages.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1890
    Keywords: Key words Deuteromycetes ; Fungi ; Fungus-host interactions ; Symbiosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Plants growing on an environmentally stressed glacier forefront on soil low in N and organic matter have abundant root colonizations by dark-septate fungi. As the plants appeared fit for this severe habitat, it was hypothesized that the dark-septate endophytes were neutral or beneficial rather than detrimental to the plants. To test this hypothesis, we designed a growth-room experiment with Pinus contorta grown on forefront soil inoculated with the dark-septate fungus Phialocephala fortinii in the absence of climatic stress. N and organic matter treatments were included to explore their interaction with the fungal inoculation. P. fortinii colonized roots inter- and intracellularly and occasionally formed microsclerotia. Inoculated plants absorbed significantly more P than noninoculated plants in all combinations of N and organic matter. Without added N, neither inoculation nor organic matter addition improved plant growth or N uptake, showing that N indeed limits plant growth in this substrate. With added N, however, both organic matter addition and inoculation significantly increased total pine biomass and N uptake. The enhanced P uptake by the P. fortinii-inoculated pine as well as the increased pine growth and N uptake in the treatment combining P. fortinii and N appear as typical mycorrhizal responses.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 16 (1993), S. 179-182 
    ISSN: 1432-0789
    Keywords: Grassland soils ; Microbial biomass ; Nitrogen fertilization ; Atrazine ; 2,4-D ; Radiometric techniques ; Herbicide mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The influence of fertilizer N on the mineralization of atrazine [2-chloro-4(ethylamino)-6(isopropylamino)-s-triazine] and 2,4-D (2,4-dichlorophenoxyacetic acid) in soils was assessed in microcosms using radiometric techniques. N equivalent to 0, 250, and 500 kg N as NH4NO3 ha-1 was added to three grassland soils. Compared to the control, the 250- and 500-kg treatments suppressed mineralization of atrazine by 75 and 54%, respectively, and inhibited mineralization of 2,4-D by 89 and 30%, respectively. Active fungal biomass responded to the N treatments in an opposite manner to herbicide mineralization. Compared to the control, the 250- and 500-kg treatments increased the active fungal biomass by more than 300 and 30%, respectively. These results agree with other observations that N can suppress the decomposition of resistant compounds but stimulate the primary growth of fungi. The degree of suppression was not related to the amount of N added nor to the inherent soil N levels before treatment. The interaction between the N additions and the active fungal biomass in affecting herbicide mineralization suggests that N may alter microbial processes and their use of C sources and thus influence rates of herbicide degradation in the field.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Journal of metastable and nanocrystalline materials Vol. 8 (May 2000), p. 267-274 
    ISSN: 1422-6375
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Social development 3 (1994), S. 0 
    ISSN: 1467-9507
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: The disclosure of 227 7th- through 12th-grade adolescents to four other persons – their closest same- and cross-sex best friends, and lesser-but-good same- and cross-sex friends – about 40 topics varying widely in intimacy was examined; in addition, each subject rated every topic's intimacy. A (2) gender × (2) friend's gender × (2) closeness × (3) age × (3) intimacy level ANOVA yielded two large main effects (partial ω2 〉 .15), closeness and topic intimacy. Three large interaction effects – gender by friend's gender, friend's gender by intimacy, and gender by closeness by intimacy – were also found, as was a moderate-sized closeness by gender by friend's gender interaction (partial co2= .08). A number of other effects were statistically significant but of only small magnitude. The perceived intimacy of 6 of the studied topics varied across age groups, and one topic, “your weight” was rated differently by males and females. The data are discussed in relation to previous research on adolescent gender differences in friendship and disclosure.
    Type of Medium: Electronic Resource
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