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  • 1
    Digitale Medien
    Digitale Medien
    Selective reductions. 33. Potassium triisopropoxyborohydride as a selective reducing agent in organic synthesis. Reaction with selected organic compounds containing representative functional groups (1984)
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 885-892 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00179a026
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  • 2
    Digitale Medien
    Digitale Medien
    A novel regiospecific alkylation of the aromatic nucleus via lithium trialkylborohydrides and aryl sulfones (1983)
    s.l. : American Chemical Society
    Organometallics 2 (1983), S. 779-780 
    Details
    ISSN: 1520-6041
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/om00078a020
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  • 3
    Digitale Medien
    Digitale Medien
    Hydroboration. 66. Addition of lithium triethylborohydride to substituted styrenes. A simple, convenient procedure for the Markovnikov hydroboration of aromatically conjugated olefins and the synthesis of unusual mixed trialkylboranes (1984)
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 1064-1071 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00180a022
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  • 4
    Digitale Medien
    Digitale Medien
    Current status of dialytic therapy in Korea (2003)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 8 (2003), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY:  The status of dialytic therapy in Korea at the end of 2001 was reported by the end-stage renal disease (ESRD) registry committee of Korean Society of Nephrology, where data were collected through an internet on-line registry program. The number of dialysis centres was 335 and the number of haemodialysis machines was 5529. The total number of patients with dialysis was 23 057 (haemodialysis 17 568, peritoneal dialysis 5489). Prevalence and incidence of dialysis patients were 477.5 and 96.4 patients per million population. The most common primary cause of end-stage renal diseases was diabetic nephropathy (41.5%), hypertensive nephrosclerosis (15.4%), and chronic glomerulonephritis (13.6%). Eighty-six percent of haemodialysis patients were on dialysis therapy three times a week, the mean urea reduction ratio was 66.7 ± 8.68% and mean Kt/V was 1.250 ± 0.292 in male patients; 1.526 ± 0.361 in female patients. The technical survival of haemodialysis in 5 years was 30.2% and peritoneal dialysis was 13.8%. The common complication of haemodialysis patients was hypertension (43.3%), gastrointestinal disease other than peptic ulcer (8.0%), congestive heart failure (7.6%), and of peritoneal dialysis patients were also hypertension (28.8%), congestive heart failure (5.0%), and peritonitis (4.8%). The most common causes of death were cardiac diseases (26.9%), vascular diseases, including cerebrovascular accidents (22.7%), and infection (17.8%).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1797.8.s.5.x
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  • 5
    Digitale Medien
    Digitale Medien
    Impact of mesangial IgA deposits in 14th-postoperative-day routine renal allograft biopsies (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY: Three hundred fourteen 14th-postoperative-day routine renal allograft biopsies were evaluated together with clinical data. Out of 314 biopsies, mesangial IgA deposits were positive in 122 biopsies (39%). According to Banff classification, the rate of acute rejection was significantly lower in mesangial IgA deposit-positive (IgA(+)) patients (7.4%) than in mesangial IgA deposit-negative (IgA(-)) patients (19.7%) on the 14th postoperative day. Thereafter, rate of biopsy-proven and clinical acute rejection was continuously lower for up to 12 months in IgA(+) patients than in IgA(-) patients. the detection rate of mesangial IgA deposits was significantly higher in human leucocyte antigen (HLA)-well-matched (HLA mismatch number was 〈3) patients than in HLA-poorly matched (HLA mismatch number was 〈3) patients. In HLA-well-matched patients, the serum creatinine levels were significantly lower in IgA(+) patients than in IgA(-) patients after 3 post-transplant months and up to 1 post-transplant year. Follow-up (mean interval: 13 months) allograft biopsies were performed in 34 patients out of 122 IgA(+) patients. In the follow-up biopsies, initially detected mesangial IgA deposits had disappeared in 22 patients (65%) out of 34 patients. Twelve patients (35%) still had mesangial IgA deposits, and all of them had clinical and pathological findings consistent with IgA nephropathy. Patients with continuous mesangial IgA deposits in the follow-up biopsies had a better renal function at 1 year and a higher 5-year graft survival rate compared with patients who lost the initially deposited IgA. the present study demonstrates that long-lasting mesangial IgA deposits in renal transplants prevent allografts from acute rejection, which leads to better graft outcome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.2002.tb00514.x
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  • 6
    Digitale Medien
    Digitale Medien
    Impact of mesangial IgA deposits in 14th-post operative-day routine renal allograft biopsies (2002)
    Oxford, UK : Blackwell Science Pty
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY: Three hundred fourteen 14th-postoperative-day routine renal allograft biopsies were evaluated together with clinical data. Out of 314 biopsies, mesangial IgA deposits were positive in 122 biopsies (39%). According to Banff classification, the rate of acute rejection was significantly lower in mesangial IgA deposit-positive (IgA(+)) patients (7.4%) than in mesangial IgA deposit-negative (IgA(-)) patients (19.7%) on the 14th postoperative day. Thereafter, rate of biopsy-proven and clinical acute rejection was continuously lower for up to 12 months in IgA(+) patients than in IgA(-) patients. The detection rate of mesangial IgA deposits was significantly higher in human leucocyte antigen (HLA)-well-matched (HLA mismatch number was 〈3) patients than in HLA-poorly matched (HLA mismatch number was ≥3) patients. In HLA-well-matched patients, the serum creatinine levels were significantly lower in IgA(+) patients than in IgA(-) patients after 3 post-transplant months and up to 1 post-transplant year. Follow-up (mean interval: 13 months) allograft biopsies were performed in 34 patients out of 122 IgA(+) patients. In the follow-up biopsies, initially detected mesangial IgA deposits had disappeared in 22 patients (65%) out of 34 patients. Twelve patients (35%) still had mesangial IgA deposits, and all of them had clinical and pathological findings consistent with IgA nephropathy. Patients with continuous mesangial IgA deposits in the follow-up biopsies had a better renal function at 1 year and a higher 5-year graft survival rate compared with patients who lost the initially deposited IgA. The present study demonstrates that long-lasting mesangial IgA deposits in renal transplants prevent allografts from acute rejection, which leads to better graft outcome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1797.7.s3.1.x
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  • 7
    Digitale Medien
    Digitale Medien
    Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 234 (2004), S. 0 
    Details
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. The mechanism and factors of virulence are not fully understood. Nicotinamidase/pyrazinamidase mutant (pncA mutant) of Brucella abortus failed to replicate in HeLa cells, and showed a lower rate of intracellular replication than that of wild-type strain in macrophages. Addition of nicotinic acid, but not nicotinamide, into medium supported intracellular replication of pncA mutant in HeLa cells and macrophages. The pncA mutant was not co-localizing with either late endosomes or lysosomes. The B. abortus virB4 mutant was completely cleared from the spleens of mice after 4 weeks, while the pncA mutant showed a 1.5-log reduction of the number of bacteria isolated from spleens after 10 weeks. Although pncA mutant showed reduced virulence in mice and defective intracellular replication, its ability to confer protection against the virulent B. abortus strain 544 was fully retained. These results suggest that PncA does not contribute to intracellular trafficking of B. abortus, but contributes to utilization of nutrients required for intracellular growth. Our results indicate that detailed characterizations of the pncA mutant may help the improvement of currently available live vaccines.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1574-6968.2004.tb09546.x
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  • 8
    Digitale Medien
    Digitale Medien
    Brucella melitensis infection associated with Guillain–Barré syndrome through molecular mimicry of host structures (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 45 (2005), S. 0 
    Details
    ISSN: 1574-695X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Brucella melitensis is a facultative intracellular bacterium that can survive inside macrophages and the causative agent of brucellosis. In the present study, we found that a lipooligosaccharide of B. melitensis has a GM1 ganglioside-like structure and shows a strong antibody response in mice. The cholera toxin B subunit, which binds to GM1 ganglioside specifically, reacted with the surface of B. melitensis. Immunization with B. melitensis induced the production of anti-GM1 ganglioside antibodies in mice and serum from immunized mice showed a cross-reaction with Guillain–Barré syndrome (GBS)-associated Campylobacter jejuni, but not non-GBS-associated C. jejuni. When B. melitensis was treated with a neuraminidase, antibody responses disappeared. B. melitensis immunization induced the production of anti-GM1 ganglioside antibodies in BALB/c mice but not in C57BL/6 and ddY mice, and for BALB/c mice, immunization with B. melitensis induced much greater production of anti-GM1 ganglioside than GBS-associated C. jejuni. Flaccid limb weakness was observed in B. melitensis immunized mice. These results suggest that B. melitensis is a new etiological agent for GBS and that immunological responses between it and GBS-associated C. jejuni in the mouse model may be different.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/j.femsim.2005.03.001
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  • 9
    Digitale Medien
    Digitale Medien
    Survival of Lactic Acid Bacteria during Spray Drying of Plain Yogurt (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 55 (1990), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Survival of Streptococcus salivarius subsp. thermophilus and Lactobacillus debrueckii subsp. bulgaricus was determined under various processing conditions for spray drying. Numbers of both microorganisms decreased with increased outlet or inlet air temperature, and atomizing air pressure. Outlet air temperature was a major parameter affecting number of survivors. Suitable conditions were inlet air 160°C, outlet air 60°C, atomizing air pressure 98 kPa, hot air flow 0.28 m3/ min, and feed temperature 30°C. Spray-dried yogurt powder showed lower survival for S. thermophilus and similar survival for L. bulgaricus as compared to freeze-dried powder.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1990.tb01585.x
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  • 10
    Digitale Medien
    Digitale Medien
    High frequency plant regeneration via somatic embryogenesis in cell suspension cultures of coriander (Coriandrum sativum L.) (1996)
    Springer
    Plant cell reports 15 (1996), S. 751-753 
    Details
    ISSN: 1432-203X
    Schlagwort(e): Abbreviations: MS, Murashige and Skoog; MS1D, MS medium + 1 mgl–1 2,4-D
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract. Hypocotyl segments and zygotic embryos of coriander formed embryogenic calli at frequencies of up to 75% when cultured on MS medium supplemented with 1 mgl–1 2,4-D. Calli were transferred to MS liquid medium with 1 mgl–1 2,4-D to initiate cell suspension cultures. Embryogenic cells became finely dispersible in the medium as the subculture proceeded. Cultures were transferred to a nitrogen compound enriched liquid MS medium containing 2% sucrose and 0.1 mgl–1 2,4-D, and cultured two weeks before plating on MS basal medium. Approximately 75% of cell aggregates (1 to two mm in diameter) underwent development into globular to cotyledonary somatic embryos after two weeks of plating. Most of the embryos were subsequently regenerated into plantlets. Regenerants were successfully transplanted to potting soil and grown to maturity in a phytotron.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002990050113
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