ISSN:
1432-1041
Keywords:
heroin
;
6-monoacetylmorphine
;
capillary gas chromatography
;
selected ion monitoring
;
GC/MS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using levallorphan as the internal standard. After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558138
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