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  • 1
    Electronic Resource
    Electronic Resource
    Heterogeneity of N-Methyl-D-Aspartate Receptors Regulating the Release of Dopamine and Acetylcholine from Striatal Slices (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 57 (1991), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an attempt to examine some functional characteristics of the N-methyl-D-aspartate (NMDA) receptor complex, the NMDA-evoked effluxes of endogenous dopamine (DA) and [3H]acetylcholine ([3H]ACh) were simultaneously examined in a rat Striatal slice preparation. NMDA induced release of both DA and ACh in a concentration-dependent, Ca2+-, Mg2+-, and tetrodotoxin-sensitive manner. These release responses were remarkably reduced by long-term pre-treatment with a low concentration of NMDA. an indication of the desensitization of the NMDA receptor. Glycine was potent in reversing the desensitization-related reduction of DA release but failed to reverse the diminution of ACh release in the same slices. Our results indicate that the NMDA receptors regulating the release of DA and ACh are different with respect to their glycine modulatory site. This finding is consistent with a functional heterogeneity of the NMDA receptor complex in the rat striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1991.tb06436.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative Characterization of Glutamate Decarboxylase in Crude Homogenates of Oviduct, Ovary, and Hypothalamus (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 43 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Some biochemical characteristics of l-glutamate decarboxylase (GAD) were compared using crude homogenates of the rat oviduct, ovary, and hypothalamus. As estimated by the measurement of CO2 production, the specific activities of oviductal and ovarian GAD were about 10 and 3% of the hypothalamic value, respectively. Stoichiometric formation of γ-aminobutyric acid (GABA) and CO2 from l-glutamate could be observed in oviduct and hypothalamus, while in ovarian homogenates the production of C02 was more than nine times that of GABA. Hypothalamic and tubal GAD showed similar time course, temperature dependence, and pH dependence. The dependence on protein concentration and on exogenous cofactor supply was also similar in these two tissues. The kinetic constant for l-glutamate as a substrate was nearly the same in oviduct (1.30 mM) and hypothalamus (1.64 mM). The responsiveness of tubal and hypothalamic GAD to various inhibitors was also similar. The present findings indicate that the oviductal and the hypothalamic GAD may be identical, and they suggest a possible GABAergic innervation of the Fallopian tube.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb06074.x
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  • 3
    Electronic Resource
    Electronic Resource
    Anwendung der Blutgruppenuntersuchungen zur Klärung strittiger Vaterschaft in Ungarn (1972)
    Springer
    International journal of legal medicine 71 (1972), S. 72-78 
    Details
    ISSN: 1437-1596
    Keywords: Vaterschaftsgutachten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Verfasser berichtet über die Entwicklung der Anwendung von Blutgruppenuntersuchungen als Beweisverfahren in familienrechtlichen Prozessen bzw. in der gerichtsmedizinischen Begutachtung der strittigen Abstammung. Gegenwärtig enthalten die in allen Rechtssachen strittiger Abstammung regelmäßig vorgenommenen Blutgruppenuntersuchungen folgende Systeme: A1A2B0, M—N, Rh (C,Cw,c,D,E,e), Hp und Gm(1),(2), Inv(1). Es bedeutet eine maximale kombinierte Ausschlußchance unter etwa 74%.
    Notes: Summary Author gives information on the progress of the application of blood group examinations as evidence in the family-law suits, or in the medico-legal opinion of disputed paternity. The blood group examinations applied at present as a routine in every suit of disputed paternity cover the following systems: A1A2B0, M–N, Rh(C,Cw,c,D,E,e), Hp and Gm(1),(2), Inv(1). It means a maximum combined chance of exclusion of about 74%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02080113
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  • 4
    Electronic Resource
    Electronic Resource
    Studies Relating to the Configuration and Conformation of 3,5-Disubstituted Dihydro-2(3H)-furanones (1989)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1989 (1989), S. 1093-1097 
    Details
    ISSN: 0170-2041
    Keywords: 2(3H)-Furanones, 3,5-disubstituted dihydro- ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Untersuchungen zur Konfiguration und Konformation von 3,5-disubstituierten Dihydro-2(3H)-furanonenInnere Prodrug-Analoge von EnalaprilChemical name of enalapril: (1S)-N-[1-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-(S)-proline maleate. wurden synthetisiert: Reduktion von (1 S)- N-[1-(Ethoxycarbonyl)-3-oxo-3-phenylpropyl]-( S)-alanyl-( S)-prolin- tert-butylester ( 1) ergab die Alkohole 2a und 2b , deren Lactonisierung lieferte (3 S ,5 S)- und (3 S ,5 R)- N-(Tetrahydro-2-oxo-5-phenyl-3-furanyl-( S)-alanyl-( S)-prolin ( 4a und 4b), die als Maleat-Salze isoliert wurden. Ihre Konfiguration und Konformation wurden durch eine Kombination von 1D- und 2D-NMR-Techniken, sowie durch CD-Untersuchung aufgeklärt. Die in-vitro-Hemmung des „Angiotensin-Converting-Enzyms“ (ACE) war bei 4a , 4b ähnlich der bei Enalapril
    Notes: Internal prodrug analogues of enalapril were obtained by reduction of (1S)-N-[1-(ethoxycarbonyl)-3-oxo-3-phenylpropyl]-(S)-alanyl-(S)-proline tert-butyl ester (1) to the alcohols 2a and 2b followed by lactonization to (3S,5S)- and (3S,5R)-N-(tetrahydro-2-oxo-5-phenyl-3-furanyl)-(S)-alanyl-(S)-proline (4a and 4b), both isolated as the maleates. Their configuration and conformation have been elucidated by a combination of 1D- and 2D-NMR techniques and with the help of CD measurements. In vitro inhibition of angiotensin-converting enzyme (ACE) by 4a and 4b has been found to be similar to that of enalapril.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198919890275
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