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  • 1
    Electronic Resource
    Electronic Resource
    Effect of cyclosporine on oxidative phosphorylation and adenylate energy charge of regenerating rat liver (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 313-320 
    Details
    ISSN: 1433-8580
    Keywords: Cyclosporine ; Liver regeneration ; Oxidative phosphorylation ; Hepatic energy charge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of cyclosporin A (CyA) on regenerating liver was investigated in subtotal hepatectomized rats treated with CyA in terms of mitochondrial phosphorylative activity, hepatic energy charge, and serum bilirubin levels. In the CyA-treated hepatectomized group, the energy charge decreased from normal control value of 0.857 to 0.782 at 6 h after hepatectomy. The decreased energy charge, however, gradually increased and returned to 0.842 at 48 h after hepatectomy with no significant changes being observed between CyA-treated and untreated hepatectomized groups. Phosphorylation rate in the CyA-untreated group increased to 142% of the normal control at 24 h and then decreased to 114% at 48 h after hepatectomy. By contrast, phosphorylation rate in the CyA-treated group increased to 144% of the normal control at 24 h, but remained at the high value of 132% (P 〈 0.01; compared to the CyA-untreated group) even at 48 h after hepatectomy. Serum total bilirubin levels in the CyA-treated group were significantly higher than those in the CyA-untreated group during all experimental periods. We conclude that CyA does not exert a direct detrimental effect on mitochondrial function and that, despite the marked hyperbilirubinemia induced by CyA, the mitochondrial phosphorylative activity increases adaptively to provide sufficient energy for enhanced ATPutilizing reactions in an early process of liver regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01855036
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in blood ketone body ratio with reference to graft viability after liver transplantation in rats (1989)
    Springer
    Transplant international 2 (1989), S. 133-136 
    Details
    ISSN: 1432-2277
    Keywords: Ketone body ratio ; in liver transplantation ; Rejection in liver transplantation ; Liver transplantation and ketone body ratio ; Liver transplantation, experimental ; Viability, liver graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Arterial blood ketone body ratio (acetoacetate/3-hydroxybutyrate; KBR), which reflects hepatic mitochondrial redox potential, was measured during a 2-week period after orthotopic liver transplantation in three groups of rats: group 1, the isogenic combination of LEW (RT11) graft to LEW recipient as control; group 2, the allogenic combination of ACI (RT1a) graft to LEW recipient without immunosuppressive treatment; and group 3, the allogenic combination of ACI to LEW with immunosuppressive treatment using cyclosporin (CyA). Isogenic recipients survived indefinitely. Allogenic recipients in group 2 had severe rejection with a mean survival of 10.3±0.54 days, while 77.8% of the allogenic recipients in group 3 survived more than 30 days. KBR of rats surviving more than 2 weeks in groups 1 and 3 gradually increased post-transplantation and was maintained at a high level. By contrast, though KBR in group 2 was restored at 3 days, it gradually fell and remained at a significantly low level (P〈0.001). It is suggested that KBR provides an accurate indicator for evaluating metabolic viability of the critically deteriorating liver graft accompanied by severe rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02414599
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    Paper (German National Licenses)
    Fulltext
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