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  • 1
    Electronic Resource
    Electronic Resource
    Plasma renin activity in folic acid induced acute renal failure (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 797-798 
    Details
    ISSN: 1432-1440
    Keywords: Folic acid ; acute renal failure ; macula densa ; peripheral plasma renin activity ; hemorrhage ; Folsäure ; akutes Nierenversagen ; Macula densa ; periphere Plasma-Reninaktivität ; Hämorrhagie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die periphere Plasma-Reninaktivität war bei Ratten mit akutem Nierenversagen, das durch eine einmalige i.v. Injektion von Folsäure (250 mg/kg KG, gelöst in 0,3 M NaHCO3) erzeugt worden war, während der ersten 6 Std normal und nach 24 Std und 4 Tagen harabgesetzt. Hämorrhagie verursachte jedoch am 4. Tag nach Folsäuregabe einen starken Anstieg der Plasma-Reninaktivität. Für eine Beteiligung des Renins an der Entwicklung des folsäurebedingten funktionellen und morphologischen Nierenschadens ergab sich kein Anhalt.
    Notes: Summary Peripheral plasma renin activity in acute renal failure induced in rats by a single i.v. injection of folic acid (250 mg/kg b. w., dissolved in 0.3 M NaHCO3) remained normal during the first 6 hours and fell to low levels 24 hours and 4 days following the injection. Bleeding, however, induced a considerable increase of plasma renin activity on the 4th day after folate injection. There was no evidence of a participation of renin in the development of the functional and morphological renal disturbances produced by folic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490312
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma renin activity in renal hypertensive rats (1972)
    Springer
    Pflügers Archiv 332 (1972), S. 232-238 
    Details
    ISSN: 1432-2013
    Keywords: Experimental Renal Hypertension ; Constriction of One Renal Artery ; Plasma Renin Activity ; Urethane Anesthesia ; Ether Anesthesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma renin activity was estimated in normal and in renal hypertensive rats, in the unanesthetized state, in ether or in urethane anesthesia. Renal hypertension was induced by partially constricting one renal artery without touching the opposite kidney. In the unanesthetized state plasma renin activity in renal hypertensive rats was slightly, though very variably, increased (∼45 percent). Ether anesthesia had no influence on plasma renin activity in either normotensive or hypertensive rats. Urethane anesthesia lowered blood pressure in normotensive controls by 20 mm Hg, and caused a more than threefold increase in plasma renin activity. In renal hypertensive rats urethane depressed blood pressure by 40 mm Hg and induced a more than sixfold increase of plasma renin activity. The results suggest that the plasma renin activity in rats with renal hypertension induced by partially constricting one renal artery and leaving the contralateral kidney untouched is not necessarily augmented. This conclusion is compatible with observations in hypertensive humans with unilateral renal artery stenosis. The previous finding of a large increase of plasma renin activity in this type of experimental hypertension is an artefact due to urethane anesthesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587450
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Disturbances of the control of renin secretion in chronic one-kidney-goldblatt hypertension in the rat (1974)
    Springer
    Pflügers Archiv 348 (1974), S. 197-204 
    Details
    ISSN: 1432-2013
    Keywords: Renal Artery Constriction ; Experimental Renal Hypertension ; “Inapropriate” Renin Secretion ; Unclamping ; Furosemide ; Nephrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Systolic blood pressure (BP) and plasma renin level (p.r.l.) were measured 1. in rats with chronic one-kidney-Goldblatt hypertension before, 1 1/2 h, 6 or 24 h after unclamping or sham-operation. 2. 6 h after 50 mg/kg furosemide i.p., and again 2 h after a subsequent nephrectomy. P.r.l. in the chronic stage of one-kidney-Goldblatt hypertension did not differ from that in normal control animals. Sham-unclamping did not influence BP and did not cause a significant increase of p.r.l. 1 1/2 h after unclamping BP fell considerably to still hypertensive levels while p.r.l. fell to less than half its normal value. 6 to 24 h after unclamping, BP continued to fall, while p.r.l. progressively rose to reach 78% of its normal value. Furosemide diuresis caused an increase of p.r.l., but no fall of BP. 2 h after subsequent nephrectomy p.r.l. fell to undetectable levels and BP to its normal value. The data suggest that the normal p.r.l. in the chronic stage of Goldblatt hypertension may be considered as inappropriate elevated in relation to blood pressure and sodium balance state due to partial protection of the kidney against regulatory influences by the presence of a clamp on the renal artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587410
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    Paper (German National Licenses)
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