ISSN:
0170-2041
Keywords:
Enzymes
;
Proteases
;
Ester hydrolysis, enzymatic
;
Isopropylideneglycerates
;
Resolution, kinetic
;
Glycerates
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In contrast to porcine pancreatic lipase (PPL), the serine proteases aP 41 and thermitase are suited as catalysts for the enantioselective ester hydrolysis of methyl (π)-2,3-O-isopropyl-ideneglycerate (rac-1). These enzymes allow the preparation of methyl (S)-(-)-2,3-O-isopropylideneglycerate (1) with an enantiomeric excess of 84-87% in a yield of 19-27% related to the starting racemate.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930118
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