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  • 1
    Electronic Resource
    Electronic Resource
    Microstructure of Yolk from Fresh Eggs by Improved Method (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 62 (1997), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Methods were examined to fix hen's egg yolk while retaining its original sol structure and to elucidate the fine structure of fresh yolk by using the freeze-cutting fixation method with liquid nitrogen. In fresh native yolk, histological differences were observed in the yolk spheres in each layer and latebra part. These spheres were closely packed in the vitelline membrane, with various sizes and shapes. Protein granules with high electron density were noted in the yolk sphere and their distribution and shape differed between the outer and inner layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1997.tb15451.x
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF A SELECTIVE ENDOTHELIN A-RECEPTOR ANTAGONIST, BQ-123, IN SALT-LOADED STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. We examined the effects of a selective endothelin A (ETA)-receptor antagonist, BQ-123, on the development of hypertension and organ damage in stroke-prone spontaneously hypertensive rats (SHRSP) given 1% NaCl for 6 weeks.2. BQ-123 at doses of 0.7, 2.1 and 7.1 mg/day was continuously administered for 6 weeks to 8 week old salt-loaded SHRSP, who were given water containing 1% NaCl for the following 6 weeks, via a subcutaneous osmotic minipump.3. Development of high blood pressure was accelerated in salt-loaded SHRSP compared with that in non-salt-loaded SHRSP. After 6 weeks of salt-loading, incidence of cerebral infarction, renal sclerosis and renal fibrosis were greater in salt-loaded than non-salt-loaded SHRSP.4. BQ-123 attenuated the age-related rise in blood pressure in a dose-dependent manner. The effect coincided with reduction in the incidence of cerebral infarction and prevention of renal sclerosis and fibrosis. Kidney function was improved as observed by an increase in glomerular filtration rate and decreases in urinary protein excretion, blood urea nitrogen and fractional sodium excretion. Furthermore, BQ-123 prevented increases in the heart weight/bodyweight ratio and aortic wall thickness in salt-loaded SHRSP.5. These results suggest that endogenous endothelin-1 (ET-1) and ETA-receptors may be, at least in part, involved in the pathogenesis of hypertension and organ damage in salt-loaded SHRSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb01932.x
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  • 3
    Electronic Resource
    Electronic Resource
    HYPERREACTIVE ARTERIAL ENDOTHELIAL CELLS: A CLUE FOR THE TREATMENT OF ATHEROSCLEROSIS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 275 (1976), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1976.tb43360.x
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of myocardial endothelin pathway improves long-term survival in heart failure (1996)
    [s.l.] : Nature Publishing Group
    Nature 384 (1996), S. 353-355 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used rats with myocardial infarction caused by coronary ligation as a model9'10 of experimental heart failure. We first investigated the effects of long-term (12 weeks) administration of an antagonist of the endothelin-A (ETA) receptor, known as BQ-123 (ref. 11), on survival and cardiac ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/384353a0
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  • 5
    Electronic Resource
    Electronic Resource
    Nucleolus organizers in the wild silkworm Bombyx mandarina and the domesticated silkworm B. mori (1988)
    Springer
    Chromosoma 96 (1988), S. 263-269 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two types (R a1 and R a2) of nucleolus organizers were identified in the genome of Bombyx mandarina (Japan) which occurs in Japan. Genetical analysis of a hybrid with B. mori suggested that the loci of both nucleolus organizers are allelic and correspond to the R 0 locus of B. mori. These nucleolus organizers segregated and were inherited by the progeny in a Mendelian fashion. The majority of the R a1 rDNA units were 10.6 kb in length and had an additional EcoRI site in the transcribed spacer region when compared with the same size unit of R 0. On the other hand, the KpnI site present in the non-transcribed spacer region of the R 0 rDNA was not detected in the R a1 unit. The 15.1 kb unit observed in the R a2 locus was the same as the unit with the type II intron of R 0. The four major components of R a2 rDNA, with lengths of 10.6, 15.1, 15.7 and 20.8 kb, were also found in the R 0 locus, and thus the R a2 and the R 0 loci were considered to be closely related. Usually the functional unit of rDNA in the nucleolus organizers of homologous or non-homologous chromosomes cannot be easily distinguished. However, in the case of B. mandarina (Japan), distinct functional 10.6 kb units were observed in the allelic R a1 and R a2 loci. Therefore the existence of the two distinct units suggest the possibility of introducing the chromosomes of the interspecies in the genus Bombyx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286912
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization and dynamics of paraquat in the stomach and esophagus of rats (1993)
    Springer
    International journal of legal medicine 106 (1993), S. 142-144 
    Details
    ISSN: 1437-1596
    Keywords: Paraquat ; Immunohistochemistry ; Rat ; Stomach ; Esophagus ; Paraquat ; Immunhistochemie ; Ratte ; Magen ; Osophagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Verteilung von Paraquat im Gewebe des Magens und des Ösophagus von Ratten wurde mittels immunhistochemischer Verfahren bestimmt. Nach intravenöser Applikation von Paraquat wurden Ratten nach Zeitspannen von 3 h, 12 h, 24 h, 3 Tagen und 10 Tagen getötet. Im Magen wurde Paraquat in den Epithelzellen in einem Zeitraum von 24h bis 10 Tagen nach Applikation gemessen, wohingegen im Ösophagus sowohl in den Epithelzellen als auch in der Lamina propria mucosa Paraquat 12 h bis 10 Tage nach Injektion gemessen werden konnte. Obwohl diese Ergebnisse mit Paraquat-Befunden im Intestinum von Ratten korrelieren, konnte keine eindeutige Zeitabhängigkeit der Verteilung beobachtet werden. Dieses Ergebnis führt zu der Annahme, daß Magen und Ösophagus als wichtige Speichergewebe an einer Redistribution von Paraquat beteiligt sind.
    Notes: Summary The dynamics of paraquat in the stomach and esophagus of rats were demonstrated using immunohistochemical techniques. The Rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In the stomach, paraquat was localized in the epithelial cells between 24h and 10 days after injection, whereas in the esophagus, paraquat was localized in epithelial cells and the lamina propria mucosa between 12 h and 10 days after administration. Although these findings were similar to those observed in the intestine of rats, no clear changes in the distribution of paraquat with time were observed; suggesting that the stomach and esophagus are important reservoirs for the redistribution of paraquat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01225235
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of Novel Residues Involved in Nuclear Localization of a Baculovirus Polyhedrin Protein (2000)
    Springer
    Virus genes 21 (2000), S. 233-240 
    Details
    ISSN: 1572-994X
    Keywords: polyhedrin ; baculovirus ; nuclear localization ; protein trafficking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A baculovirus polyhedrin protein has proven to possess a nuclear localization signal (NLS) sequence and a domain required for supramolecular assembly. Here we investigated five Bombyx mori nucleopolyhedrovirus (BmNPV) mutants that did not produce polyhedra. Two of five mutants were generated during routine baculoviral expression vector screening, and three were isolated by treatment with the mutagen 5-bromo-2′-deoxyuridine (BrdU). Marker rescue mapping and nucleotide sequence analysis showed that mutations in the polyhedrin gene caused the altered phenotype of these mutants. Biochemical fractionation indicated that cells infected with these mutants exhibited polyhedrin protein in both the nucleus and the cytoplasm. Electron microscopic observation revealed that polyhedrin produced by these mutants ocurred in both the nucleus and the cytoplasm, but did not form a crystalline lattice. Despite the incompleteness of polyhedrin nuclear localization, the NLSs of the five mutants were unchanged, although some of the mutations occurred within residues just outside of the domain reported to be required for polyhedron assembly (4). This result suggests that (a) the polyhedrin NLS directs polyhedrin to the nucleus, but the efficiency of this localization is regulated by regions other than the NLS (probably, polyhedrin conformation and its association with the nucleus are also involved), and (b) formation of a crystalline lattice may also be determined by several domains within polyhedrin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008151916849
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  • 8
    Electronic Resource
    Electronic Resource
    Distribution of endothelin-1 in the lung of rats with pulmonary hypertension of different etiology (1998)
    Springer
    The international journal of angiology 7 (1998), S. 160-164 
    Details
    ISSN: 1615-5939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide and induces vascular smooth muscle cell proliferation. We previously reported that an ET receptor antagonist prevented the progression of pulmonary hypertension (PH) caused by inflammatory lung disease in rats. The aim of the present study was to investigate whether pathophysiological roles of endogenous ET-1 in PH caused by congestive heart failure (CHF) differ from PH caused by inflammatory lung disease. For this purpose, we investigated the distribution of ET-1 staining (ET-1-like immunoreactivity) by the immunohistochemical method using an anti-ET-1 antibody in the lungs of rats with PH due to CHF or inflammatory lung disease. CHF was surgically induced by permanent left coronary arterial ligation in rats. At 2 weeks after the surgery in rats, left ventricular contractility (LV+dP/dtmax) was decreased, whereas right ventricular systolic pressure was increased, indicating that the rats developed CHF accompanied by PH. The intensity of ET-1 staining was stronger in the pulmonary vascular endothelial cells of the CHF rats than that of the sham-operated rats. We used monocrotaline (MCT)-induced PH rats (MCT rats) as a model of PH due to inflammatory lung disease. Three weeks after MCT injection, the MCT rats developed PH. The intensity of ET-1 staining in the pulmonary vascular endothelial cells of the MCT rats did not differ from that of the control rats, however, the intensity of the ET-1 staining in the MCT rats was increased in the alveolar walls (especially in macrophages). These data show that the distribution of ET-1 staining in the lungs of the rats with PH due to CHF differs from that of the rats with PH due to inflammatory lung disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01618391
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis of N-substituted phenoxazine polymers bearing vinyl backbone (1986)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 24 (1986), S. 1565-1575 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Vinyl monomers bearing N-substituted phenoxazine or 2,8-dimethylphenoxazine units were synthesized starting with the corresponding phenoxazines. N-substituents were 2-vinylbenzyl-oxycarbonylethyl group prepared via 2-carboxyethyl group, 3-methacrylamido-, 3-acrylamido-, or 3-(4-styrenesulfonamido)-propyl group prepared via 3-aminopropyl group, vinylbenzyl, or 2-vinyloxyethyl group attached by the displacements of sodium salts of the phenoxazines to the chlorides, and 2-methacryloyl- or 2-acryloyl-oxyethyl group prepared via 2-hydroxyethyl group. Free-radical polymerixations of these novel monomers proceeded smoothly, except those with 2-vinyloxyethyl group, which were susceptible to BF3-etherate. Changes of the visible absorption spectrum of iodine in THF with addition of the monomers and polymers were considerable, with the appearance of new absorption peaks or shoulders in major cases.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1986.080240714
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  • 10
    Electronic Resource
    Electronic Resource
    Bonding of chemically treated titanium implants to bone (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 37 (1997), S. 267-275 
    Details
    ISSN: 0021-9304
    Keywords: titanium implants ; chemical treatment ; bone bonding ; apatite layer ; tensile testing ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A study was undertaken in rabbit tibiae to determine the effects of chemical treatments and/or surface-induced bonelike apatite on the bone-bonding ability of titanium (Ti) implants. Smooth-surfaced plates (10 × 10 × 2 mm) of pure Ti, alkalil- and heat-treated Ti, and bonelike apatite-formed Ti after the treatments were implanted into the tibial metaphyses of mature rabbits. The tibiae containing the implants were harvested at 4, 8, and 16 weeks after implantation and subjected to a tensile testing and histologic evaluation. Biomechanical results showed that both treated implants exhibited significantly higher failure loads compared with untreated Ti implants at all time periods. Histologic examination by Giemsa surface staining, contact microradiography (CMR), and scanning electron microscopy (SEM) in backscatter mode revealed that both treated Ti implants directly bonded to bone tissue during the early postimplantation period, whereas untreated Ti implants formed direct contact with the bone only at 16 weeks. SEM-electron-probe microanalysis (EPMA) examination showed a Ca-P-rich layer at the interface between the treated implants and bone, although the Ca-P-rich layer was not detected on the surface of untreated implants during observation periods. The results of this study suggest that chemical treatments may accelerate the bone-bonding behavior of titanium implants and enhance the strength of bone-implant bonding by inducing a bioactive surface layer on Ti implants. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 267-275, 1997.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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