ISSN:
1432-0843
Keywords:
Key words Cytarabine ocfosfate
;
Colorectal adenocarcinoma
;
Nude mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-β-D-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00685794
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