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  • 1
    Electronic Resource
    Electronic Resource
    Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To characterize apoptosis in keloids and the mechanisms responsible for this process, the expression of activated caspase-9 and -3 in fibroblasts obtained from keloids was analyzed. Immunohistochemistry revealed that the number of fibroblasts positive for terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) or activated caspase-9 or -3 was low but was significantly higher in keloid tissues than in normal scar tissues. Significant relationships between the number of caspase-positive fibroblasts and TUNEL-positive fibroblasts suggested that the activation of caspase-9 and -3 induces apoptosis in a subpopulation of keloid fibroblasts. All keloid fibroblast cell lines established in this study showed activation of caspase-9 and -3 after serum deprivation for 3 or 4 hours, as shown using Western blotting. Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts. Although serum deprivation did not significantly change the level of apoptosis protease activating factor-1 in any of the lines, cytochrome c release was detected in cytosolic fractions of the lines after serum deprivation for 3 or 4 hours. These results strongly suggest that keloid fibroblasts are predisposed to apoptosis and cytochrome c release and that caspase-9 activation may underlie regulation of apoptosis in keloid fibroblasts in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130404.x
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  • 2
    Electronic Resource
    Electronic Resource
    The eosinophilic and amyloid-like materials in adenomatoid odontogenic tumor (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 11 (1982), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This paper is concerned with the relationship between eosinophilic material (EM) and amyloid-like material in adenomatoid odontogenic tumors. In duct-like structures and between opposing rows of tall columnar cells, EM did not stain for amyloid. Under electron microscopy, EM was composed of fibrillar and granular materials, and the fibrillar material was not amyloid. Two different kinds of EM were found in solid cell masses. Lesions from cases 2, 3, 4 and part of case 1 contained small droplet-shaped EM and these EM did not stain for amyloid. Case 1 also contained EM that stained positively for amyloid. The structure of amyloid positive EM resembled developing enamel of human tooth germs. This material was tubular and finely granular. The tubular material resembled enamel matrix fibers rather than amyloid and the fine granular material was stippled. The cells surrounding EM appeared similar to ameloblasts between secretory and maturation stages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1982.tb00150.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Uncommon dermoid cyst presented in the mandible possibly originating from embryonic epithelial remnants (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of oral pathology & medicine 31 (2002), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of an intraosseous dermoid cyst that had developed in the mandible of a 29-year-old-male is reported. The patient was admitted to our dental clinic complaining of pain in the right molar area of the mandible. The patient had no particular history of the present illness. A radiographic examination revealed diffuse bone absorption in the right molar area. A biopsy showed the lesion to be an intraosseous dermoid cyst which was surgically enucleated. Microscopic examination of the excised tissue showed it to be well circumscribed with fibrous tissues, and the cystic space lined by keratinized epithelium. In addition, sweat glands and hair follicle-like skin appendages were identified in the cystic wall, where a daughter cyst was also found. We suggested that this uncommon cyst had developed in the mandible, as a result of embryonic epithelium migration. The patient remained in good health during the three year follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0714.2002.310311.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Radiographic appearance of fibrous dysplasia associated with the maxillary sinus (1995)
    Springer
    Oral radiology 11 (1995), S. 23-30 
    Details
    ISSN: 1613-9674
    Keywords: fibrous dysplasia ; maxillary sinus ; radiographic findings ; computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fibrous dysplasia is a relatively rare tumorous lesion in the maxillofacial region. The radiographic appearance of this lesion varies widely in the jaw. Generally, the occurrence rate is higher in the maxilla than in the mandible. The purpose of this study was to report six cases of fibrous dysplasia associated with the maxillary sinus. In this study, we examined radiographic patterns which demonstrated the lesion's affect on the sinus radiographically. Mixed radiopacity and radiolucency (the so-called ground glass appearance) was also seen in each of these cases. In four cases in which CT images were obtained, the lesion showed buccal expansion and infiltration into the maxillary sinus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347906
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    Paper (German National Licenses)
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