ISSN:
1432-2307
Keywords:
v-src oncogene
;
Rous sarcoma virus
;
Fibrohistiocytic tumour
;
Immunohistochemistry
;
Southern blotting
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The observation that v-src-induced tumors contain tumor cells of differing morphology, notably fibroblastoid or polygonal, raised the question as to whether the tumor cells are also heterogeneous with respect to expression of markers of cellular differentiation. Of the markers tested here, consistent reactivity for tumor tissue was noted only for antibody probes reactive to muscle actin (HHF35, αsm-1) or to procollagen type I (SP1. D8); for any given tumor, whether induced by v-src DNA or by Rous sarcoma virus, each of these markers was found only in a subpopulation of tumor cells. The observation of marker heterogeneity in the one v-src DNA-induced tumor examined here that typed as monoclonal suggests that v-src-induced transformation is consonant with a degree of plasticity in the phenotypes of the clonal progeny of a single transformant.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00197397
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