Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
4 (1977), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. The pharmacokinetics of methyldopa after oral and intravenous administration was studied in hypertensive and normotensive patients. After intravenous administration methyldopa plasma concentrations decayed according to a two-compartment open model.2. For intravenous administration the overall elimination constant Ke1 was 0.56 ± 0.03 h−1, the volume of distribution of the central compartment 0.29±0.08 1 kg−1 and the plasma clearance rate 11.2±0.6 1 h−1.3. Plasma half-times during the β-phase of the methyldopa plasma decay curve following intravenous and oral administration were 2.8±1.3 and 2.1±0.7 h, respectively.4. Maximal plasma levels in hypertensive out-patients show great variation and range from 0 to 1.9 μg ml−1.5. No relationships were found between maximal methyldopa plasma levels in patients under treatment and control of hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1977.tb02670.x
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