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  • 1
    Electronic Resource
    Electronic Resource
    Reactivity of cholinoceptive cortical neurons to the repeated action of acetylcholine (1986)
    Springer
    Bulletin of experimental biology and medicine 101 (1986), S. 245-247 
    Details
    ISSN: 1573-8221
    Keywords: neuron ; acetylcholine ; microiontophoresis ; reactivity ; plasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00835908
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  • 2
    Electronic Resource
    Electronic Resource
    The reflex pathways of the anticoagulation system (1961)
    Springer
    Bulletin of experimental biology and medicine 52 (1961), S. 750-753 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Further evidence has been obtained that the physiological anticoagulation system in rats is of a reflex-humoral nature. The reflex arc involves the medulla oblongata.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811625
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  • 3
    Electronic Resource
    Electronic Resource
    Abstracts of papers deposited at VINITI (1978)
    Springer
    Russian physics journal 21 (1978), S. 543-552 
    Details
    ISSN: 1573-9228
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00895574
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  • 4
    Electronic Resource
    Electronic Resource
    The role of cGMP in the extinction of the reactions of identified neurons of the edible snail in response to acetylcholine (1990)
    Springer
    Neuroscience and behavioral physiology 20 (1990), S. 323-330 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The possible role of cGMP in the regulation of the extinction of the reactions of the RPa4, RPa3, and LPa3 neurons of the edible snail in response to acetylcholine (ACh), applied rhythmically to the soma of the neuron by means of microiontophoresis, has been investigated. It was demonstrated that activators of guanylate cyclase which increased the level of cGMP in the cell, namely, sodium nitroprusside and sodium azide (5·104 103 mole/liter), when applied intracellularly, intensify the extinction of inward transmembrane current and of depolarization of the membrane in response to ACh. The hypothesis of the participation of cGMP-dependent phosphorylation of membrane proteins in the regulation of the rate of development, depth, and duration of short-lived plasticity of the cholinoreceptors of the neuron is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01236326
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  • 5
    Electronic Resource
    Electronic Resource
    Regulation by calcium of short-term plasticity of the cholinoreceptors of RPa3 and LPa3 neurons of the edible snail (1991)
    Springer
    Neuroscience and behavioral physiology 21 (1991), S. 1-7 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The pharmacological influences which change the intracellular content of free Ca2+ reversibly change the rate and depth of the extinction of the inward current of RPa3 and LPa3 neurons of the edible snail, elicited by repeated iontophoretic applications of acetylcholine to the soma. Suppression by a calciumfree extracellular medium and by verapamil (100–150 μmoleslliter) of the influx of Ca+ into the cell, induced by the activation of cholinoreceptors, reversibly attenuates the extinction. An increase in the level of intracellular Ca+ by ruthenium red blockade (5–10 μmoleslliter) of the specific transport of Ca+ by the mitochondria and by caffeine mobilization (1–4 mmoleslliter) of Ca2+ deposited by the endoplasmic reticulum increases and intensifies extinction. The results obtained indicate that the short-term plasticity of the cholinoreceptors of these neurons is positively regulated by Ca2+ which has entered the cell along chemoregulated ion channels, and has been mobilized from the intracellular Ca depots.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01184230
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  • 6
    Electronic Resource
    Electronic Resource
    Transformation of the afferent tactile signal into a motor command in the cat motor cortex (1980)
    Springer
    Neuroscience and behavioral physiology 10 (1980), S. 374-381 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Activity of 112 neurons of the precruciate motor cortex in cats was studied during a forelimb placing reaction to tactile stimulation of its distal parts. The latent period of response of the limb to tactile stimulation was: for flexors of the elbow (biceps brachii) 30–40 msec, for the earliest reponses of cortical motor neurons about 20 msec. The biceps response was observed 5–10 msec after the end of stimulation of the cortex with a series of pulses lasting 25 msec. Two types of excitatory responses of the neurons were identified: responses of sensory type observed to each tactile stimulation of the limb and independent of the presence or absence of motion, and responses of motor type, which developed parallel with the motor response of the limb and were not observed in the absence of motion. The minimal latent period of the responses of motor type was equal to the latent period of the sensory responses to tactile stimulation (20±10 msec). Stimulation of the cortex through the recording microelectrode at the site of derivation of unit activity, which increased during active flexion of the forelimb at the elbow (11 stimuli at intervals of 2.5 msec, current not exceeding 25 μA), in 70% of cases evoked an electrical response in the flexor muscle of the elbow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01184053
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  • 7
    Electronic Resource
    Electronic Resource
    Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail (1991)
    Springer
    Neuroscience and behavioral physiology 21 (1991), S. 289-295 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A reversible decrease in the rate and depth of the extinction of the reactions of the cholinoreceptive membrane to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockers way demonstrated in identified RPa3 and LPa3 neurons in the edible snail using the method of recording transmembrane ionic currents: R 24571 (20–50 μmoles/liter), trifluoperazine (50–200 μmoles/liter), chlorpromazine (20–60 μnoles/liter), and prenylamine lactate (30–400 μmoles/liter). The results obtained attest to the positive regulation of short-term plasticity of the cholinoreceptors of the neurons in question by calmodulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191567
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  • 8
    Electronic Resource
    Electronic Resource
    Arachidonic acid and its acyclic derivatives regulate short-term plasiticity of the cholinoreceptors of neurons of the edible snail (1992)
    Springer
    Neuroscience and behavioral physiology 22 (1992), S. 393-400 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The influence of eicosanoids on the dynamics of the extinction of the inward current, induced by repeated iontophoretic appplications of acetylcholine to the soma has been demonstrated in identified RPa3 and LPa3 neurons of the edible snail by means of bielectrode recording of the membrane potential. The extracellular action of arachidonic acid (50–100 Μmole/l) intensifies the extinction. Quinacrine (100–600 Μmole/l), an inhibitor of phosphopholipase A2, which decreases the content of arachidonic acid in the cells, acts ambiguously. Nordihydroguaiaretic acid (3–10 Μmole/l), which is an inhibitor of the lipoxygenase oxidation of arachidonic acid, attenuates the extinction. Indomethacin (10–50 Μmole/l), a blocker of cyclooxygenase oxidation of arachidonic acid, does not influence extinction. All of the compounds investigated decrease the amplitude of the inward current induced by acetylcholine. The results obtained make it possible to hypothesize that arachidonic acid and its acyclic metabolites, which are formed as a result of lipoxygenase oxidation, regulate short-term plasticity of the cholinoreceptors of neurons of the edible snail. The cyclic eicosanoids which are formed during the cyclooxygenase oxidation of arachidonic acid do not exert a regulatory effect on the plasticity of the cholinoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01186631
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  • 9
    Electronic Resource
    Electronic Resource
    Neuronal activity of motor cortex during elaboration of a motor reflex conditioned to electrical stimulation of the thalamic ventrolateral nucleus (1982)
    Springer
    Neuroscience and behavioral physiology 12 (1982), S. 462-470 
    Details
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusions 1. A motor response of the cat foreleg was conditioned to electrical stimulation of the ventrolateral nucleus of the thalamus via one of two chronically in-dwelling electrodes (1), with differentiation of stimulation via the other electrode (2). With subsequent retraining of the same animals, the signal value of the stimuli was reversed, so that the positive conditioned signal came from electrical stimulation via electrode 2, and the differential signal came via electrode 1. 2. Independent of which electrode delivered the positive or differential stimulus, during performance of the conditioned response the biceps EMG showed a response to the conditional stimulation, the minimal LP being 8–12 msec. With positive and differential stimuli appearing in random order, the EMG response to differential stimulation was significantly less expressed or absent. 3. Regardless of which of the two electrodes delivered the positive and differential stimuli, the short-latency (LP less than 6 and 12 msec after positive stimuli) excitatory components of the response of the motor cortical neurons were greater in magnitude than the corresponding components after differential stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01186859
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  • 10
    Electronic Resource
    Electronic Resource
    Transformation of the afferent tactile signal into a motor command in the cat motor cortex (1977)
    Springer
    Neurophysiology 9 (1977), S. 83-90 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Activity of 112 neurons of the precruciate motor cortex in cats was studied during a forelimb placing reaction to tactile stimulation of its distal parts. The latent period of response of the limb to tactile stimulation was: for flexors of the elbow (biceps brachii) 30–40 msec, for the earliest reponses of cortical motor neurons about 20 msec. The biceps response was observed 5–10 msec after the end of stimulation of the cortex with a series of pulses lasting 25 msec. Two types of excitatory responses of the neurons were identified: responses of sensory type observed to each tactile stimulation of the limb and independent of the presence or absence of motion, and responses of motor type, which developed parallel with the motor response of the limb and were not observed in the absence of motion. The minimal latent period of the responses of motor type was equal to the latent period of the sensory responses to tactile stimulation (20±10 msec). Stimulation of the cortex through the recording microelectrode at the site of derivation of unit activity, which increased during active flexion of the forelimb at the elbow (11 stimuli at intervals of 2.5 msec, current not exceeding 25 µA), in 70% of cases evoked an electrical response in the flexor muscle of the elbow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01062395
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