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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of lhrh agonists, clinical aspects
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 20 (1984), S. 1369 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(84)90423-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-Hydroxy-1-phosphabicyclo[3.3.1]nonane P-sulfide (1999)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 0-0 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270199098534
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    cis-1-Phosphabicyclo[4.3.0]nonane P-sulfide (1999)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 0-0 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270199098522
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Performance differences between addicts and non-addicts (1977)
    Springer
    Psychopharmacology 52 (1977), S. 299-306 
    Details
    ISSN: 1432-2072
    Keywords: Methadone addicts ; Reaction time ; Attention ; Visual sensitivity ; Acute methadone ; Chronic methadone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methadone addicts and non-addict controls were tested before and after receiving up to 10 mg of methadone on simple visual reaction time tests and on a vigilance type visual attention test. Addicts were faster than controls on pre-drug testing, although there were no pre-drug differences between groups on the attention task. Addicts maintained faster reaction times than controls even when money was offered as an incentive for speed. Additional methadone did not affect addict performance on any of the tasks. Methadone slowed control reaction times in a doserelated fashion. No significant attention decrements were seen after methadone in controls. Visual reaction time differences between addicts and controls cannot be attributed to group differences in motivation or ability to attend. Slowing of reaction time with acute dose of methadone in controls cannot be attributed to the effect of the drug on attention. An hypothesized drug-induced decrease in visual sensitivity with acute dose in controls and a drug-induced increase in visual sensitivity with chronic dose in addicts can account for the presented data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426715
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and endocrine effects of the LHR analogue buserelin after subcutaneous implantation of a slow release preparation in prostatic cancer patients (1989)
    Springer
    Urological research 17 (1989), S. 43-46 
    Details
    ISSN: 1434-0879
    Keywords: Metastatic prostate cancer ; LHRH analogues ; Implant preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics and endocrine effects of the LHRH analogue buserelin [D-Ser(TBU)6-LHRH], released from biodegradable implants, were studied in 14 patients with stage C and D prostate cancer. Six patients received a subcutaneous implant of 3.3 mg buserelin monthly, and 8 patients received a subcutaneous implant of 6.6 mg buserelin every two months. Serum levels of buserelin decreased rapidly immediately after implantation. After 1–2 weeks a more gradual decline occurred, while in the two-monthly treated group a third phase of the elimination curve started after 5 weeks. Mean serum buserelin levels just before the next implantation in the two groups were not different. Urinary excretion of buserelin followed the same pattern. Serum LH levels in both groups became non-detectable 2 weeks after the first implant. This decrease of LH levels was accompanied by a suppression of serum testosterone to concentrations below 1 nmol/l (castration level). Side effects were not different from those observed with the intranasal application of buserelin. It is concluded that the subcutaneous application of buserelin is an easily administered form of treatment which has more profound and more reliable endocrine effects when compared with the intranasal administration of the drug. The greatest advantage of the new preparation is that the intervals between applications may be prolonged to at least 2 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261050
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  • 6
    Electronic Resource
    Electronic Resource
    Destructive changes of the spine in magnetic resonance imaging (1990)
    Springer
    Archives of orthopaedic and trauma surgery 109 (1990), S. 133-138 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine patients were examined by magnetic resonance imaging for various lesions of the spine. The results of these scans were compared with those of plain radiographs, computertomographs, and radionuclide bone scans. The findings were substantiated by intraoperative or histological findings in 18 cases. The MRI scans proved to be very sensitive in the detection of a wide spectrum of morphological changes of the bone marrow of vertebral bodies. Characteristic changes of the signal patterns for inflammatory and tumorous lesions were not observed. The differentiation of these lesions will presently continue to have to be based on morphological criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00440573
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    Paper (German National Licenses)
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