ISSN:
0899-0042
Keywords:
chromatographic resolution of stereoisomers
;
molecular modelling
;
conformation
;
κ-opiate receptor
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The four stereoisomers of the two peripherally selective κ-opioid agonists EMD 60 400 and EMD 61 753 were synthesized, tested for stereoisomeric purity, and examined for affinity to the κ opioid receptor. The relationships between the configuration of these molecules and their biological activity are discussed. © 1994 Wiley-Liss, Inc.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530060814
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