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  • 1
    Electronic Resource
    Electronic Resource
    Induction of an antibody response in mice against human papillomavirus (HPV) type 16 after immunization with HPV recombinant Salmonella strains (1996)
    Springer
    Cancer immunology immunotherapy 43 (1996), S. 44-48 
    Details
    ISSN: 1432-0851
    Keywords: Key words Human papilloma virus ; Cancer ; Vaccine ; Salmonella typhimurium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Human papillomaviruses (HPV) are present in approximately 95% of all cervical carcinomas and the HPV E6 and E7 genes are continuously expressed in these lesions. There is also circumstantial evidence that often natural immunity against HPV is generated and that this is of influence on HPV-induced lesions. Stimulation of the immune system by proper presentation of relevant HPV antigens might, therefore, lead to a prophylactic or therapeutic immunological intervention for HPV-induced lesions. For this purpose we have expressed the E6 and E7 protein of HPV 16 in an attenuated strain of Salmonella typhimurium (SL3261, aroA mutation), which has been used extensively as a live vector. Live recombinant Salmonella vaccines have the ability to elicit humoral, secretory and cell-mediated immune responses, including cytotoxic T cells, against the heterologous antigens they express. This report describes the construction of recombinant Salmonella strains expressing the HPV 16 E6 and E7 proteins, and the induction of an HPV-16-specific immune response in mice after immunization with these live vectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050302
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis ofEscherichia coli isolates from subjects with travellers' diarrhoea using DNA probes and serotyping (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 625-629 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Escherichia coli isolated from faeces of 54 healthy volunteers who visited Tunisia for eight days were examined. These volunteers participated in a randomized doubleblind placebo-controlled study to establish whether ciprofloxacin could prevent travellers' diarrhoea.Escherichia coli strains isolated before travel, during episodes of travellers' diarrhoea, immediately after return and five weeks after return were serotyped and tested for the presence of virulence genes indicating diarrheogenic properties by hybridization with a set of four non-radioactively labelled DNA probes. Subjects receiving ciprofloxacin prophylactically to prevent travellers' diarrhoea were asymptomatic and noEscherichia coli could be cultured shortly after return home. Sixty-four percent of subjects (18/28) who did not receive antibiotic prophylaxis suffered from travellers' diarrhoea. Hybridization tests detected 8 enterotoxigenicEscherichia coli strains producing heat stable toxin, 13 enterotoxigenic strains producing heat labile toxin and 10 strains which produced both heat labile and stable toxin. Of the 31 probe positive strains, 29 (94 %) were cultured from 11 volunteers with travellers' diarrhoea. A bacterial cause was thus determined in 61 % of the volunteers who experienced travellers' diarrhoea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975813
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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