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  • 1
    Electronic Resource
    Electronic Resource
    Scaling and interpolation for dimensionally generalized electronic structure (1993)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 2467-2478 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100112a058
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  • 2
    Electronic Resource
    Electronic Resource
    Large-order dimensional perturbation theory for two-electron atoms (1992)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 97 (1992), S. 8481-8496 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: An asymptotic expansion for the electronic energy of two-electron atoms is developed in powers of δ=1/D, the reciprocal of the Cartesian dimensionality of space. The expansion coefficients are calculated to high order (∼20 to 30) by an efficient recursive procedure. Analysis of the coefficients elucidates the singularity structure in the D→∞ limit, which exhibits aspects of both an essential singularity and a square-root branch point. Padé–Borel summation incorporating results of the singularity analysis yields highly accurate energies; the quality improves substantially with increase in either D or the nuclear charge Z. For He, we obtain 9 significant figures for the ground state and 11 for the 2p2 3Pe doubly excited state, which is isomorphic with the ground state at D=5 by virtue of interdimensional degeneracy. The maximum accuracy obtainable appears to be limited only by accumulation of roundoff error in the expansion coefficients. The method invites application to systems with many electrons or subject to external fields.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.463419
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  • 3
    Electronic Resource
    Electronic Resource
    CD69 expression and tumour necrosis factor-α immunoreactivity in the inflammatory cell infiltrate of halo naevi (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been suggested that the involution of the pigmented lesions of halo naevus (HN) is mediated by an immune response, with the involvement of specific cytotoxic T lymphocytes. To explore further the pathogenesis of HN. skin biopsies from six patients with this condition were obtained and the characteristics of the infiltrating inflammatory ceils were studied by immunostaining techniques. We found that the cell infiltrate of HN is mainly composed by CD8+ T lymphocytes that express the activation molecule CD69. Tumour necrosis factor-α (TNF-α) immunoreactivity was detected on the inflammatory cells, a finding that suggests that the infiltrating T cells of HN are actively synthesizing this cytokine. Our results indicate that the infiltrating cells of HN predominantly have an activated cytotoxic phenotype, and suggest that these cells are indeed involved in the regression of the naevomelanocytic naevus of HN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.20755.x
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of indorenate on food intake: a comparison with fenfluramine and amphetamine (1995)
    Springer
    Psychopharmacology 117 (1995), S. 91-101 
    Details
    ISSN: 1432-2072
    Keywords: Indorenate ; Food intake ; Fenfluramine ; Anorexia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Indorenate (TR3369, 5-methoxytryptamine b-methylcarboxylate HCl) is a 5-HT1-like receptor agonist with hypotensive activity. Here, we describe that indorenate also decreases food intake (ED50 26.1 mg/kg) without an appreciable effect in water intake (the estimated ED50 for water was 589.8 mg/kg). The anorectic activity of indorenate was compared to the effects of amphetamine and other serotonin agonists; the effect of indorenate was smaller than those of the other compounds; however, the effect of indorenate was specific to food, whereas all the other drugs also produced significant decrements in water intake. The serotonin antagonists cinanserin, cyproheptadine, methergoline and methysergide effectively prevented the decrease in food intake produced by indorenate and fenfluramine. Haloperidol, a dopaminergic antagonist, was ineffective in preventing the effect of indorenate although it prevented the anorectic effect of amphetamine. The present results suggest the participation of serotoninergic, but not dopaminergic mechanisms, in the decrease in food intake produced by indorenate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245103
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of destruction of the 5-hydroxytryptaminergic pathways on the acquisition of temporal discrimination and memory for duration in a delayed conditional discrimination task (1996)
    Springer
    Psychopharmacology 123 (1996), S. 103-110 
    Details
    ISSN: 1432-2072
    Keywords: 5-Hydroxytryptamine ; 5,7-Dihydroxytryptamine ; Operant behaviour ; Time ; discrimination ; Memory for duration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on the acquistion of a temporal discrimination and on memory for duration, using a delayed conditional discrimination task. In phase I, rats that had received injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei, and shamlesioned control rats, were trained in a series of discrete trials to press lever A following a 2-s presentation of a light stimulus, and lever B following an 8-s presentation of the same stimulus. Following stimulus offset, a response on a panel placed midway between the two levers was required in order to intiate lever presentation; a single response on either lever resulted in withdrawal of both levers and, in the case of a “correct” response, reinforcer delivery. Both groups gradually acquired accurate discrimination, achieving 〉90% correct choices within 20–30 sessions; the lesioned group acquired accurate performance significantly faster than the control group. In phase II, delays were interposed between stimulus offset and lever presentation in 50% of the trials (2, 4, 8, 16 and 32 s; 10% of trials in each case). Accuracy declined as a function of post-stimulus delay in both groups, and there was no significant difference between the performances of the two groups. Both groups showed an increasing tendency to respond on lever A following longer post-stimulus delays (“choose-short” effect); this effect was somewhat enhanced in the lesioned group. The levels of 5HT and 5-hydroxyindoleacetic acid were reduced in the brains of the lesioned rats, but the levels of noradrenaline and dopamine were not altered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246287
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  • 6
    Electronic Resource
    Electronic Resource
    The role of the ascending 5-hydroxytryptaminergic pathways in timing behaviour: further observations with the interval bisection task (1995)
    Springer
    Psychopharmacology 120 (1995), S. 213-219 
    Details
    ISSN: 1432-2072
    Keywords: 5-hydroxytryptamine ; 5,7-Dihydroxytryptamine ; Operant behaviour ; Timing ; Interval bisection procedure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This experiment examined the effect of destroying the 5-hydroxytryptaminergic (5HTergic) pathways on rats' ability to discriminate between two durations. Rats received injections of 5,7-dihydroxytryptamine into the median and dorsal raphe nuclei or sham lesions. They were trained to press lever A following a 2-s presentation of a light and lever B following an 8-s presentation of the light. For some rats, the levers were inserted into the chamber immediately after stimulus presentation (“no-poke-requirement”); for others, the levers were not inserted until a flap covering the food tray positioned midway between the levers had been depressed (“poke-requirement”). When stable performance was attained, “probe” trials were introduced in which the light was presented for intermediate durations. Logistic functions were derived relating percent choice of lever B to log stimulus duration. Under the “no-poke-requirement” condition, the bisection point (duration yielding 50% choice of lever B) was shorter in the lesioned rats than in the control rats. Under the “poke-requirement” condition, this effect of the lesion was attenuated. There was no effect of the lesion on the Weber fraction under either condition. The levels of 5HT and 5-hydroxyindoleacetic acid were reduced in the brains of the lesioned rats, but the levels of noradrenaline and dopamine were not altered. It is proposed that rats may attain accurate timing under the interval bisection task by moving from one lever to the other during stimulus presentation; this movement may be facilitated by destruction of the 5HTergic pathways. Accurate timing is still possible when this movement is suppressed by the introduction of a “poke requirement”; however, in this case timing is not affected by 5HT depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246196
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of desipramine and fluvoxamine on timing behaviour investigated with the fixed-interval peak procedure and the interval bisection task (1996)
    Springer
    Psychopharmacology 125 (1996), S. 274-284 
    Details
    ISSN: 1432-2072
    Keywords: Antidepressants ; Desipramine ; Fluvoxamine ; Timing ; Fixed-interval peak procedure ; Interval bisection task ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute treatment with antidepressant drugs is known to increase the mean interresponse time (IRT) in the IRT 〉72-s schedule of reinforcement. In order to examine the possibility that this effect may reflect an action of the antidepressants on timing processes, we tested the effects of two antidepressants, desipramine and fluvoxamine, on behaviour maintained under two other timing schedules in rats. In the fixed-interval peak procedure (fixed-interval 30-s), acute treatment with desipramine (8 mg kg−1) reduced response rate, whereas acute treatment with fluvoxamine (8 mg kg−1) increased it. Neither drug significantly altered the time to attainment of peak response rate or the Weber fraction. In the interval bisection task (standard durations 2 s and 8 s), the bisection point was not significantly altered by acute treatment with either drug. Chronic treatment with desipramine (8 mg kg−1 b.d.) had no effect on any of the indices of timing under either schedule. Chronic treatment with fluvoxamine (8 mg kg−1 b.d.) reduced the time to attainment of peak response rate but had no effect on the Weber fraction under the fixed-interval peak procedure, and did not alter the bisection point or Weber fraction under the interval bisection procedure. The failure of desipramine and fluvoxamine to increase the time to peak response rate or the bisection point at doses that significantly altered operant response rate suggests that the effect of these drugs on IRT schedule performance is unlikely to reflect an interaction with timing processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247339
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